WO2007046871A3 - Apparatus and method for non-contact microfluidic sample manipulation - Google Patents

Apparatus and method for non-contact microfluidic sample manipulation Download PDF

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Publication number
WO2007046871A3
WO2007046871A3 PCT/US2006/020178 US2006020178W WO2007046871A3 WO 2007046871 A3 WO2007046871 A3 WO 2007046871A3 US 2006020178 W US2006020178 W US 2006020178W WO 2007046871 A3 WO2007046871 A3 WO 2007046871A3
Authority
WO
WIPO (PCT)
Prior art keywords
liquid sample
liquid
particles
hydrodynamic
pathogens
Prior art date
Application number
PCT/US2006/020178
Other languages
English (en)
French (fr)
Other versions
WO2007046871A2 (en
Inventor
Hsueh-Chia Chang
Diana Hou
Siddharth Maheshwari
Zachary Gagnon
Lesile Yeo
Original Assignee
Univ Notre Dame Du Lac
Hsueh-Chia Chang
Diana Hou
Siddharth Maheshwari
Zachary Gagnon
Lesile Yeo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US72784805P priority Critical
Priority to US60/727,848 priority
Application filed by Univ Notre Dame Du Lac, Hsueh-Chia Chang, Diana Hou, Siddharth Maheshwari, Zachary Gagnon, Lesile Yeo filed Critical Univ Notre Dame Du Lac
Publication of WO2007046871A2 publication Critical patent/WO2007046871A2/en
Publication of WO2007046871A3 publication Critical patent/WO2007046871A3/en

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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C5/00Separating dispersed particles from liquids by electrostatic effect
    • B03C5/02Separators
    • B03C5/022Non-uniform field separators
    • B03C5/026Non-uniform field separators using open-gradient differential dielectric separation, i.e. using electrodes of special shapes for non-uniform field creation, e.g. Fluid Integrated Circuit [FIC]
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
    • B01F13/00Other mixers; Mixing plant, including combinations of mixers, e.g. of dissimilar mixers
    • B01F13/0059Micromixers
    • B01F13/0074Micromixers using mixing means not otherwise provided for
    • B01F13/0076Micromixers using mixing means not otherwise provided for using electrohydrodynamic [EHD] or electrokinetic [EKI] phenomena to mix or move the fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
    • B01F5/00Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F2005/0002Direction of flow or arrangement of feed and discharge openings
    • B01F2005/002Tangential flow, i.e. flow spiraling in a tangential direction in a flat plane or beltlike area
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0647Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668Trapping microscopic beads
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0816Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867Multiple inlets and one sample wells, e.g. mixing, dilution
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/089Virtual walls for guiding liquids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0424Dielectrophoretic forces
PCT/US2006/020178 2005-10-19 2006-05-24 Apparatus and method for non-contact microfluidic sample manipulation WO2007046871A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US72784805P true 2005-10-19 2005-10-19
US60/727,848 2005-10-19

Publications (2)

Publication Number Publication Date
WO2007046871A2 WO2007046871A2 (en) 2007-04-26
WO2007046871A3 true WO2007046871A3 (en) 2007-11-08

Family

ID=37962953

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/020178 WO2007046871A2 (en) 2005-10-19 2006-05-24 Apparatus and method for non-contact microfluidic sample manipulation

Country Status (1)

Country Link
WO (1) WO2007046871A2 (sv)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8308926B2 (en) 2007-08-20 2012-11-13 Purdue Research Foundation Microfluidic pumping based on dielectrophoresis
WO2010004516A1 (en) * 2008-07-08 2010-01-14 Ipgrip, Inc. System and methods for in-line monitoring of particles in opaque flows and selective object manipulation in multi-component flow

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4383265A (en) * 1980-08-18 1983-05-10 Matsushita Electric Industrial Co., Ltd. Electroosmotic ink recording apparatus
US6673225B1 (en) * 1998-05-29 2004-01-06 Industrial Research Limited Method and apparatus for concentrating and/or positioning particles or cells
US6805783B2 (en) * 2000-12-13 2004-10-19 Toyo Technologies, Inc. Method for manipulating a solution using a ferroelectric electro-osmotic pump
US6911132B2 (en) * 2002-09-24 2005-06-28 Duke University Apparatus for manipulating droplets by electrowetting-based techniques

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4383265A (en) * 1980-08-18 1983-05-10 Matsushita Electric Industrial Co., Ltd. Electroosmotic ink recording apparatus
US6673225B1 (en) * 1998-05-29 2004-01-06 Industrial Research Limited Method and apparatus for concentrating and/or positioning particles or cells
US6805783B2 (en) * 2000-12-13 2004-10-19 Toyo Technologies, Inc. Method for manipulating a solution using a ferroelectric electro-osmotic pump
US6911132B2 (en) * 2002-09-24 2005-06-28 Duke University Apparatus for manipulating droplets by electrowetting-based techniques

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KAWAMOTO ET AL.: "Electrohydrodynamic deformation of water surface in a metal pin to water plate corona discharge system", J. PHYS. D. APPL. PHYS., vol. 38, 2005, pages 887 - 894, XP020083589, DOI: doi:10.1088/0022-3727/38/6/017 *
OHYAMA ET AL.: "Flow Visualization and Image analysis of Gas-phase AC Corona Discharge Induced Electrohydrodynamic Liquid Flow in a Strafield Fluid", IEEE TRANSACTIONS ON DIELECTRICS AND ELECTRICAL INSULATION, vol. 10, no. 1, February 2003 (2003-02-01), pages 58 - 60 *

Also Published As

Publication number Publication date
WO2007046871A2 (en) 2007-04-26

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