WO2007042983A3 - Fluridone as an anti-inflammatory agent - Google Patents

Fluridone as an anti-inflammatory agent Download PDF

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Publication number
WO2007042983A3
WO2007042983A3 PCT/IB2006/053669 IB2006053669W WO2007042983A3 WO 2007042983 A3 WO2007042983 A3 WO 2007042983A3 IB 2006053669 W IB2006053669 W IB 2006053669W WO 2007042983 A3 WO2007042983 A3 WO 2007042983A3
Authority
WO
WIPO (PCT)
Prior art keywords
fluridone
disclosed
inflammatory activity
active compound
inflammatory agent
Prior art date
Application number
PCT/IB2006/053669
Other languages
French (fr)
Other versions
WO2007042983A2 (en
Inventor
Elena Zocchi
Lucrezia Guida
Santina Bruzzone
Sonia Scarfi
Mirko Magnone
Giovanna Basile
Umberto Benatti
Flora Antonio De
Iliana Moreschi
Luisa Franco
Annalisa Salis
Original Assignee
Univ Degli Studi Genova
Elena Zocchi
Lucrezia Guida
Santina Bruzzone
Sonia Scarfi
Mirko Magnone
Giovanna Basile
Umberto Benatti
Flora Antonio De
Iliana Moreschi
Luisa Franco
Annalisa Salis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Degli Studi Genova, Elena Zocchi, Lucrezia Guida, Santina Bruzzone, Sonia Scarfi, Mirko Magnone, Giovanna Basile, Umberto Benatti, Flora Antonio De, Iliana Moreschi, Luisa Franco, Annalisa Salis filed Critical Univ Degli Studi Genova
Priority to US12/089,203 priority Critical patent/US7786042B2/en
Priority to EP06821174A priority patent/EP1948174B1/en
Publication of WO2007042983A2 publication Critical patent/WO2007042983A2/en
Publication of WO2007042983A3 publication Critical patent/WO2007042983A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to a novel use of fluridone - compound known per se and used as an aquatic erbicide - in the medical field, in particular as an active compound for preparing a medicament having anti-inflammatory activity. Pharmaceutical compositions comprising fluridone as an active compound and pharmaceutically acceptable carriers and/or diluents are also disclosed. Finally, there is disclosed the pro-inflammatory activity of abscisic acid (ABA), a plant hormone which is also found in mammal serum and against which fluridone acts an an inhibitor.
PCT/IB2006/053669 2005-10-07 2006-10-06 Fluridone as an anti-inflammatory agent WO2007042983A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/089,203 US7786042B2 (en) 2005-10-07 2006-10-06 Fluridone as an anti-inflammatory agent
EP06821174A EP1948174B1 (en) 2005-10-07 2006-10-06 Fluridone as an anti-inflammatory agent

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000708A ITTO20050708A1 (en) 2005-10-07 2005-10-07 FLURIDONE AS AN ANTI-INFLAMMATORY AGENT
ITTO2005A000708 2005-10-07

Publications (2)

Publication Number Publication Date
WO2007042983A2 WO2007042983A2 (en) 2007-04-19
WO2007042983A3 true WO2007042983A3 (en) 2007-07-26

Family

ID=37882171

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/053669 WO2007042983A2 (en) 2005-10-07 2006-10-06 Fluridone as an anti-inflammatory agent

Country Status (4)

Country Link
US (1) US7786042B2 (en)
EP (1) EP1948174B1 (en)
IT (1) ITTO20050708A1 (en)
WO (1) WO2007042983A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8389024B2 (en) * 2005-06-22 2013-03-05 Gonzalo Romero M. Abscisic acid against cancer
RU2361587C1 (en) * 2008-02-14 2009-07-20 Михаил Владимирович Кутушов Medical product for treatment of oncologic diseases
EP2391360B1 (en) * 2009-01-28 2017-09-06 Virginia Tech Intellectual Properties, Inc. Method of synergistically enhancing the therapeutic efficacy and safety of medications through a combination therapy
CN105878224A (en) 2010-09-17 2016-08-24 美商华仑生物科学公司 Compositions Of Abscisic Acid For Animal Health

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3958025A (en) * 1972-10-06 1976-05-18 Livingston Virginia W C Abscisic acid tablets and process
EP0240257A2 (en) * 1986-03-27 1987-10-07 University of Lancaster Compounds and pharmaceutical preparations having calcium - regulatory activity
WO1998048808A1 (en) * 1997-04-28 1998-11-05 Parapro Llc, Limited Liability Company Of Indiana Herbicide anti-apicomplexa protozoan parasite agents
US20040117125A1 (en) * 1999-04-26 2004-06-17 Hao Chen Drug discovery method and apparatus

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6329429B1 (en) * 1997-06-25 2001-12-11 Warner-Lambert Company Use of GABA analogs such as Gabapentin in the manufacture of a medicament for treating inflammatory diseases

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3958025A (en) * 1972-10-06 1976-05-18 Livingston Virginia W C Abscisic acid tablets and process
EP0240257A2 (en) * 1986-03-27 1987-10-07 University of Lancaster Compounds and pharmaceutical preparations having calcium - regulatory activity
WO1998048808A1 (en) * 1997-04-28 1998-11-05 Parapro Llc, Limited Liability Company Of Indiana Herbicide anti-apicomplexa protozoan parasite agents
US20040117125A1 (en) * 1999-04-26 2004-06-17 Hao Chen Drug discovery method and apparatus

Also Published As

Publication number Publication date
US20080242705A1 (en) 2008-10-02
ITTO20050708A1 (en) 2007-04-08
US7786042B2 (en) 2010-08-31
EP1948174A2 (en) 2008-07-30
EP1948174B1 (en) 2012-08-01
WO2007042983A2 (en) 2007-04-19

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