WO2007041502A3 - Procedes pour la determination de la sensibilite a la therapie cancereuse - Google Patents

Procedes pour la determination de la sensibilite a la therapie cancereuse Download PDF

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Publication number
WO2007041502A3
WO2007041502A3 PCT/US2006/038451 US2006038451W WO2007041502A3 WO 2007041502 A3 WO2007041502 A3 WO 2007041502A3 US 2006038451 W US2006038451 W US 2006038451W WO 2007041502 A3 WO2007041502 A3 WO 2007041502A3
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WO
WIPO (PCT)
Prior art keywords
methods
cancer therapy
determining responsiveness
molecular tags
binding
Prior art date
Application number
PCT/US2006/038451
Other languages
English (en)
Other versions
WO2007041502A2 (fr
Inventor
Chris Petropoulos
Mike Bates
Colombe Chappey
Sharat Singh
Ali Mukherjee
Mengxiang Tang
Original Assignee
Monogram Biosciences
Chris Petropoulos
Mike Bates
Colombe Chappey
Sharat Singh
Ali Mukherjee
Mengxiang Tang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monogram Biosciences, Chris Petropoulos, Mike Bates, Colombe Chappey, Sharat Singh, Ali Mukherjee, Mengxiang Tang filed Critical Monogram Biosciences
Publication of WO2007041502A2 publication Critical patent/WO2007041502A2/fr
Publication of WO2007041502A3 publication Critical patent/WO2007041502A3/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Dans certains aspects, la présente invention a trait à des procédés et des compositions pour déterminer si une cellule cancéreuse est susceptible de réagir à un traitement avec un agent activité Her2. De préférence, les procédés de l'invention sont mis en oeuvre à l'aide d'ensembles de composés de liaison ayant des étiquettes moléculaires libérables qui sont spécifiques pour de constituants multiples d'un ou de plusieurs types de dimères. Suite à la liaison, les étiquettes moléculaires sont libérées et séparées du mélange de dosage pour analyse.
PCT/US2006/038451 2005-09-30 2006-09-29 Procedes pour la determination de la sensibilite a la therapie cancereuse WO2007041502A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72270905P 2005-09-30 2005-09-30
US60/722,709 2005-09-30

Publications (2)

Publication Number Publication Date
WO2007041502A2 WO2007041502A2 (fr) 2007-04-12
WO2007041502A3 true WO2007041502A3 (fr) 2007-10-25

Family

ID=37906799

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/038451 WO2007041502A2 (fr) 2005-09-30 2006-09-29 Procedes pour la determination de la sensibilite a la therapie cancereuse

Country Status (1)

Country Link
WO (1) WO2007041502A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9110066B2 (en) 2009-01-15 2015-08-18 Laboratory Corporation Of America Holdings HER-3 antibodies and methods of use

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2129396T1 (sl) 2007-02-16 2013-12-31 Merrimack Pharmaceuticals, Inc. Protitelesa proti ErbB3 in njihove uporabe
CA2711843C (fr) * 2007-12-20 2018-11-13 Laboratory Corporation Of America Holdings Procedes de diagnostic du her-2
EP2313780B1 (fr) * 2008-07-08 2015-05-20 George Mason Research Foundation, Inc. C-erbb2 phosphorylé en tant que marqueur théranostique prédictif supérieur pour le diagnostic et le traitement du cancer
EA022884B1 (ru) 2008-08-15 2016-03-31 Мерримак Фармасьютикалз, Инк. СПОСОБ ЛЕЧЕНИЯ ЗЛОКАЧЕСТВЕННОЙ ОПУХОЛИ С ИСПОЛЬЗОВАНИЕМ АНТИ-ErbB3 АНТИТЕЛА
SG177252A1 (en) 2008-12-01 2012-03-29 Lab Corp America Holdings METHODS AND ASSAYS FOR MEASURING p95 AND/OR p95 IN A SAMPLE AND ANTIBODIES SPECIFIC FOR p95
DK2544680T3 (en) 2010-03-11 2015-04-27 Merrimack Pharmaceuticals Inc USE OF ErbB3 INHIBITORS IN TREATMENT OF TRIPLE-NEGATIVE BREAST CANCER
EP3087394A2 (fr) 2013-12-27 2016-11-02 Merrimack Pharmaceuticals, Inc. Profils de biomarqueur pour prédire les résultats d'une thérapie cancéreuse utilisant des inhibiteurs d'erbb3 et/ou des chimiothérapies
US10184006B2 (en) 2015-06-04 2019-01-22 Merrimack Pharmaceuticals, Inc. Biomarkers for predicting outcomes of cancer therapy with ErbB3 inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050130238A1 (en) * 2003-04-01 2005-06-16 Po-Ying Chan-Hui ErbB surface receptor complexes as biomarkers

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050130238A1 (en) * 2003-04-01 2005-06-16 Po-Ying Chan-Hui ErbB surface receptor complexes as biomarkers

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TOVEY ET AL.: "Can Molecular Markers Predict When to Implement Treatment with Aromatase Inhibitors in Invasive Breast Cancer?", CLIN. CANCER RES., vol. 11, no. 13, July 2005 (2005-07-01), pages 4835 - 4842 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9110066B2 (en) 2009-01-15 2015-08-18 Laboratory Corporation Of America Holdings HER-3 antibodies and methods of use

Also Published As

Publication number Publication date
WO2007041502A2 (fr) 2007-04-12

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