WO2007041035A2 - Composition orale et technique de diminution du stress associe a l'arret du tabac - Google Patents

Composition orale et technique de diminution du stress associe a l'arret du tabac Download PDF

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Publication number
WO2007041035A2
WO2007041035A2 PCT/US2006/037043 US2006037043W WO2007041035A2 WO 2007041035 A2 WO2007041035 A2 WO 2007041035A2 US 2006037043 W US2006037043 W US 2006037043W WO 2007041035 A2 WO2007041035 A2 WO 2007041035A2
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Prior art keywords
composition
stress
tobacco
chewing gum
urge
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PCT/US2006/037043
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English (en)
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WO2007041035A3 (fr
Inventor
David J. Cai
Kevin B. Broderick
Michael J. Greenberg
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Wm. Wrigley Jr. Company
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Priority to EP06815211A priority Critical patent/EP1928259A2/fr
Publication of WO2007041035A2 publication Critical patent/WO2007041035A2/fr
Publication of WO2007041035A3 publication Critical patent/WO2007041035A3/fr

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
    • A23G4/068—Chewing gum characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F47/00—Smokers' requisites not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Definitions

  • the invention relates generally to aids for treating tobacco or nicotine habits and, more particularly, to oral compositions, such as chewing gum and confectionary compounds, formulated to relieve psychological and physiological stress associated with smoking cessation.
  • One type of product includes a transdermal patch, which allows the person's body to slowly absorb a prescribed amount of nicotine over a given period. Little by little the dosage of nicotine in the patches is decreased until the person is no longer addicted. Once the physical addiction to nicotine is overcome, the person can more easily fight the psychological stress associated with smoking cessation.
  • Another type of product is sold in the form of a chewing gum containing nicotine. Thus, whenever a smoker has the urge to smoke, the smoker will chew the gum instead. However, the smoker still has to restrict the use of the gum in a manner that will eventually overcome the addiction.
  • Devices and methods involving nicotine therapy all necessarily depend on the use of nicotine, the substance causing addiction, to control nicotine craving or desire. This approach is thus susceptible to abuse, and users are known to become addicted to the use of gum, patches or the like, and not to decrease nicotine intake as instructed.
  • users are known to concurrently use both tobaccos, as in cigarettes, and nicotine therapy aids, such as gum or patches, thereby increasing the total intake of nicotine.
  • acute adverse medical consequences may result, including increased heart rate, increased blood pressure and other conditions associated with nicotine administration. Accordingly, the use of nicotine therapy may actually increase the stress associated with smoking cessation.
  • There are certain herbal preparations that are known to have been used as smoking materials, including use in non-tobacco cigarettes.
  • nicotine- free herbal compositions have been used either as a substitute for or in combination with tobacco.
  • This smoking composition may include Laurus nobilis and Nelumbo garetin.
  • herbs such as Plantago major, Piper methysticum, and Hypericum perforatum have been used in herbal preparations for aid in cessation of tobacco.
  • non-nicotine chewing gum and confectionary smoking cessation aids have been developed.
  • citrus leaf powder, oat extract, and tea extracts have been used in an anti-smoking chewing gum.
  • Other non-nicotine confections have been formulated containing sugar substitutes.
  • sugar alcohols, maltitol and lactitol, and menthol or mint flavor have been used in smoking control confections.
  • a confectionary composition is formulated to reduce stress and the urge to smoke in abstaining tobacco users.
  • the composition includes at least one of a sugar or a sugar alcohol and an effective amount of a stress- reducing flavoring agent sufficient to substantially reduce the urge to consume tobacco products.
  • a chewing gum composition is formulated to reduce stress and the urge to smoke in abstaining tobacco users.
  • the composition includes a water soluble bulk portion, a water insoluble base portion, and at least one stress-reducing flavoring agent sufficient to substantially reduce the urge to smoke.
  • a method of reducing the urge to smoke in abstaining tobacco users includes orally administering a confectionary composition having an amount of stress-reducing flavoring agent effective to substantially reduce the urge to smoke during periods of smoking abstinence.
  • a method of reducing stress in tobacco users who must temporarily abstain from tobacco use includes orally administering a confectionary composition having an amount of stress-reducing flavoring agent effective to substantially reduce the urge to smoke during periods of smoking abstinence.
  • a method of reducing consumption of tobacco by a tobacco user by increasing the interval between consumption events comprising orally administering a confectionary composition having an amount of stress-reducing flavoring agent effective to substantially reduce the urge to smoke during periods of smoking abstinence.
  • the stress-reducing flavoring agent can be one or more of peppermint flavor, vanilla flavor, or fruit flavors, such as peach flavor.
  • Confectionary compositions can be used as vehicles for delivering components to the oral cavity which provide benefits such as breath freshening and antibactericidal properties.
  • Such systems have the advantage of providing a consumer with a convenient and inexpensive method for maintaining oral health and fresh breath throughout the course of the day.
  • Chewing gums and confections such as hard and soft candies also provide the user with certain psychological benefits. The action of chewing a gum or sucking on a candy can provide a form of relaxation and provide relief of stress and tension in the body.
  • an oral delivery vehicle preferably a confectionary product such as a chewing gum or the like, containing an effective amount of a stress-reducing flavoring agent
  • a confectionary product such as a chewing gum or the like, containing an effective amount of a stress-reducing flavoring agent
  • Suitable confectionary products include tablets, lozenges, hard and soft candies, pressed mints, and the like.
  • the term "masticated” as used herein includes operations by which a chewing gum or candy is partially or wholly consumed while it is being held in the mouth, such as by chewing, sucking, or dissolving. Holding the product in the moujh for Ion er periods of time is expected to be associated with greater levels of stress reduction in an abstaining tobacco user.
  • the present invention provides a confectionary that reduces the anxiety in tobacco users when they cannot smoke. For example, during travel on commercial airlines, while at meetings, while in non-smoking restaurants, and the like. These are situations in which tobacco users must temporarily abstain from tobacco use. Accordingly, the present invention contemplates a method in which a confection containing a stress-reducing flavoring agent is used to relieve stress in tobacco users ' who must temporarily abstain from tobacco use.
  • the present invention also provides a confectionary that, when used, effectively increases the time period between tobacco use episodes by reducing the urge to smoke or otherwise use or consume tobacco products. By relieving the stress associated with abstaining from tobacco use, the overall consumption of tobacco products can be reduced in individuals desiring to permanently abstain from tobacco use.
  • the invention provides a method of assisting tobacco users in overcoming a tobacco use habit.
  • an oral composition includes an effective amount of a flavoring agent such as peppermint or vanilla or both.
  • an oral composition includes an effective amount of a fruit flavoring agent, such as peach.
  • the values shown in Table 1 are Visual Analog Scale Values in which the subjects indicated on a 100mm line scale the degree of their subjective urge to smoke. The scale values ranged from 0 (no urge to smoke) to 100 (maximum urge to smoke).
  • both peppermint and vanilla flavored chewing gums substantially reduced the urge to smoke in comparison with no chewing gum. Further, the study showed that, overall, vanilla flavored chewing gum had a more pronounced effect on the urge to smoke than peppermint flavored chewing gum. The vanilla flavored chewing gum reduced the urge to smoke by about 24% compared with no chewing gum.
  • vanilla flavored chewing gum reduced the urge to smoke in the female subjects by about 31%, while the peppermint chewing gum had a much less pronounced reduction.
  • the peppermint flavored chewing gum reduced the urge to smoke by about 21%, while the vanilla flavored chewing gum had a slightly less effect on the urge to smoke.
  • the values listed in Table 2 are the average of the subject's self-reported severity of eleven smoking cessation-related symptoms.
  • the values for each symptom are provided on a four-point scale.
  • the values for each symptom range from 0 (not present) to 3 (severe).
  • the maximum possible score when all eleven symptoms are at their highest level for any one subject is 33 .
  • both peppermint flavored chewing gum and vanilla flavored chewing gum substantially reduced the total withdrawal symptoms.
  • the peppermint and vanilla flavored chewing gums reduced the total withdrawal symptoms by 30% and 18%, respectively.
  • peppermint flavored chewing gum reduced the total withdrawal symptoms by about 30%, while the vanilla flavored chewing gum reduced the total withdrawal symptoms by about 24%.
  • the peppermint flavored chewing gum reduced the total withdrawal symptoms by about 28%, while the vanilla flavored chewing gum showed much less effect.
  • the stress associated with abstaining from the use of tobacco products can be substantially reduced by consuming a confectionary composition having a stress-reducing flavoring agent.
  • the following examples illustrate various embodiments of the invention for oral compositions including stress-reducing flavoring agents.
  • a flavor such as peppermint, vanilla, peach flavor or other stress-reducing flavoring agents can be used to formulate a chewing gum.
  • the present invention also provides a chewing gum comprising a water insoluble base portion, a water soluble base portion, and a stress- relieving flavoring agent.
  • the water soluble portion dissipates with a portion of the flavor over a period of time during chewing.
  • the gum base portion is retained in the mouth throughout the chew.
  • the chewing gum may be any of a variety of different chewing gums, including low or high moisture, sugar or sugarless, wax-containing or wax-free, low calorie and/or a chewing gum that includes dental health agents.
  • the insoluble gum base generally comprises elastomers, resins, fats and oils, softeners, and inorganic fillers.
  • the gum base may or may not include wax.
  • the insoluble gum base can constitute about 5 to about 95 percent, by weight, of the chewing gum, more commonly, the gum base comprises about 10 to about 50 percent of the gum, and in some preferred embodiments, about 20 to about 35 percent, by weight, of the chewing gum.
  • the chewing gum base contains about 20 to about 60 weight percent synthetic elastomer, about 0 to about 30 weight percent natural elastomer, about 5 to about 55 weight percent elastomer plasticizer, about 4 to about 35 weight percent filler, about 5 to about 35 weight percent softener, and optional minor amounts (about one percent or less) of miscellaneous ingredients such as colorants, antioxidants, and the like.
  • Synthetic elastomers may include, but are not limited to, polyisobutylene with a GPC weight average molecular weight of about 10,000 to about 95,000, isobutylene-isoprene copolymer (butyl elastomer), styrene-butadiene copolymers having styrene-butadiene ratios of about 1 :3 to about 3:1, polyvinyl acetate having a GPC weight average molecular weight of about 2,000 to about 90,000, polyisoprene, polyethylene, vinyl acetate- vinyl laurate copolymer having vinyl laurate content of about 5 to about 50 percent by weight of the copolymer, and combinations thereof.
  • Preferred ranges are, for polyisobutylene, about 50,000 to about 80,000 GPC weight average molecular weight, for styrene-butadiene, 1:1 to 1:3 bound styrene-butadiene, for polyvinyl acetate, 10,000 to 65,000 GPC weight average molecular weight with the higher molecular weight polyvinyl acetates typically used in bubble gum base, and for vinyl acetate-vinyl laurate, vinyl laurate content of about 10 to about 45 percent.
  • Natural elastomers may include natural rubber such as smoked or liquid latex and guayule as well as natural gums such as jelutong, lechi caspi, perillo, sorva, massaranduba balata, massaranduba chocolate, nispero, rosindinha, chicle, gutta hang kang, and combinations thereof.
  • the preferred synthetic elastomer and natural elastomer concentrations vary depending on whether the chewing gum in which the base is used is adhesive or conventional, bubble gum or regular gum, as discussed below.
  • Preferred natural elastomers include jelutong, chicle, sorva and massaranduba balata.
  • Elastomer plasticizers may include, but are not limited to, natural rosin esters such as glycerol esters of partially hydrogenated rosin, glycerol esters polymerized rosin, glycerol esters of partially dimerized rosin, glycerol esters of rosin, pentaerythritol esters of partially hydrogenated rosin, methyl and partially hydrogenated methyl esters of rosin, pentaerythritol esters of rosin; synthetics, such as terpene resins derived from alpha-pinene, beta-pinene, and/or d-limonene; and any suitable combinations of the foregoing, the preferred elastomer plasticizers will also vary depending on the specific application, and on the type of elastomer which is used.
  • natural rosin esters such as glycerol esters of partially hydrogenated rosin, glycerol esters polymerized rosin, gly
  • Fillers/texturizers may include magnesium and calcium carbonate, ground limestone, silicate types such as magnesium and aluminum silicate, clay, alumina, talc, titanium oxide, mono-, di- and tri-calcium phosphate, cellulose polymers, such as wood, and combinations thereof.
  • Water insoluble softeners and emulsif ⁇ ers are typically incorporated into the gum base at levels between 5 and 50%. These may include fats such as tallow, hydrogenated tallow, hydrogenated and partially hydrogenated vegetable oils, cocoa butter; fatty ingredients such as glycerol monostearate and other mono- and diglycerides, glycerol triacetate, lecithin, acetylated mono- and diglycerides, fatty acids (e.g. stearic, palmitic, oleic and linoleic acids), waxes such as paraffin and microcrystalline waxes and combinations thereof.
  • fats such as tallow, hydrogenated tallow, hydrogenated and partially hydrogenated vegetable oils, cocoa butter
  • fatty ingredients such as glycerol monostearate and other mono- and diglycerides, glycerol triacetate, lecithin, acetylated mono- and diglycerides, fatty acids (e.g. stearic, palm
  • Colorants and whiteners may include FD&C-type dyes and lakes, fruit and vegetable extracts, titanium dioxide, and combinations thereof.
  • the gum base may or may not include wax.
  • An example of a wax-free gum base is disclosed in U.S. Pat. No. 5,286,500, the disclosure of which is incorporated herein by reference.
  • a typical chewing gum composition includes a water soluble bulk portion and one or more flavoring agents.
  • the water soluble portion can include bulk sweeteners, high intensity sweeteners, flavoring agents, softeners, emulsifiers, colors, acidulants, fillers, antioxidants, and other components that provide desired attributes.
  • Bulk sweeteners include both sugar and sugarless components. Bulk sweeteners typically constitute about 5 to about 95% by weight of the chewing gum, more typically, about 20 to about 80% by weight, and more commonly, about 30 to about 60% by weight of the gum.
  • Sugar sweeteners generally include saccharide-containing components commonly known in the chewing gum art, including, but not limited to, sucrose, dextrose, maltose, dextrin, dried invert sugar, fructose, levulose, galactose, corn syrup solids, and the like, alone or in combination.
  • Sugarless sweeteners include, but are not limited to, sugar alcohols such as sorbitol, mannitol, xylitol, hydrogenated starch hydrolysates, maltitol, and the like, alone or in combination, and polymeric sucrose replacers including maltodextrins, polydextrose, and hydrogenated starch hydrolysate (HSH).
  • High intensity artificial sweeteners can also be used, alone or in combination with the above.
  • Preferred sweeteners include, but are not limited to sucralose, aspartame, Neotame, salts of acesulfame, such as the synthetic sweetener
  • 3,6-dihydro-6-methyl-l-l,2,3-oxathiazin-4-one-2,2-dioxide particularly the potassium substituted sweetener (Acesulfame-K), alitame, saccharin and its salts, cyclamic acid and its salts, glycyrrhizin, dihydrochalcones, thaumatin, monellin, and the like, alone or in combination.
  • usage level of the artificial sweetener will vary greatly and will depend on such factors as potency of the sweetener, rate of release, desired sweetness of the product, level and type of flavor used and cost considerations. Thus, the active level of artificial sweetener may vary from about 0.02 to about 8%. When carriers used for encapsulation are included, the usage level of the encapsulated sweetener will be proportionately higher.
  • Encapsulated sweeteners can also be incorporated into the gum formulation.
  • the encapsulation techniques that can be used can give varying degrees of coating from partial to full coating depending on the coating composition used in the process.
  • the coating compositions may be susceptible to water permeating to various degrees.
  • compositions that have high organic solubility, good film forming properties, and low water solubility provide a better encapsulation of aspartame.
  • Such compositions include acrylic polymers and copolymers, carboxyvinyl polymers, polyamides, polystyrene, polyvinyl acetate, polyvinyl acetate phthalate, polyvinyl pyrrolidone, and waxes.
  • the encapsulant should be preferably at least about 20% of the coated product. More preferably, the encapsulant should be at least about 30% of the coated product, and most preferably should be at least about 40% of the coated product. Depending on the coating material, a higher or lower amount of coating material may be needed to provide the desired encapsulation.
  • Another method of partial encapsulation is agglomeration with an agglomerating agent, which partially coats aspartame.
  • This method includes the step of mixing the aspartame and agglomerating agent with a small amount of water or solvent. The mixture is prepared in such a way as to have individual wet particles in contact with each other so a partial coating can be applied. After the water or solvent is removed, the mixture is ground and used as a powdered coated encapsulated aspartame.
  • agglomerating agent Materials that can be used as the agglomerating agent are the same as those used in the encapsulation previously mentioned. However, since the coating is only a partial encapsulation, some agglomeration agents are more effective than others. Some of the better agglomerating agents are organic polymers such as acrylic polymer and copolymers, polyvinyl acetate, polyvinyl pyrrolidone, waxes, shellac and Zein. Other agglomerating agents may not be as effective as are the polymers, waxes, shellac and Zein.
  • agglomerating agents include, but are not limited to, agar, alginates, a wide range of cellulose derivatives, dextrin, gelatin, modified starches, and vegetable gums such as guar gums, locust bean gum, and carrageenan.
  • the level of coating used in the agglomerated product should be at about 5%.
  • the coating level should be at least about 15%, and more preferably about 20%.
  • Aspartame may be coated in a two-step process or multiple step process. Aspartame maybe encapsulated with any of the materials previously described and then the encapsulated material can be agglomerated as previously described to obtain an encapsulated/agglomerated product that could be used in chewing gum to improve stability.
  • Combinations of sugar and/or sugarless sweeteners may be used in chewing gum. Additionally, the softener may also provide additional sweetness such as with aqueous sugar or alditol solutions.
  • a low calorie bulking agent can be used.
  • low caloric bulking agents include: polydextrose; Raftilose, Raftilin; Fructooligosaccharides (NutraFlora); Palatinose oligosaccharide; Guar Gum Hydrolysate (Sun Fiber); or indigestible dextrin (Fibersol).
  • other low calorie bulking agents can be used.
  • Softeners are added to the chewing gum in order to optimize the chewability and mouth feel of the gum.
  • Softeners also known in the art as plasticizers or plasticizing agents, generally constitute between about 0.5% to about 15% of the chewing gum. These include glycerin, propylene glycol and aqueous sweetener solutions such as those containing sorbitol. Hydrogenated starch hydrolysate and corn or other starch hydrolysate syrups (sometimes called glucose syrups) and combinations thereof are particularly preferred as they also function as binders to improve the flexibility and other physical properties of the gum.
  • a variety of additional flavoring agents can be used.
  • the flavor can be used in amounts of approximately about 0.1 to about 10 weight percent of the gum, and preferably, about 0.3 to 2%.
  • Flavoring agents may include essential oils, synthetic flavors or mixtures thereof including, but not limited to, oils derived from plants and fruits. In addition to peppermint oil, vanilla, and peach, other mint oils including spearmint oil, can be added. Artificial flavoring agents and components may also be used. Natural and artificial flavoring agents may be combined in any sensorially acceptable fashion.
  • the stress-reducing flavoring agent can be in the form of a spray-dried flavor.
  • Spray-drying of the flavor oils can be accomplished by conventional spray-drying techniques whereby a carrier solution or mixture containing the flavor oil is fed through a pressure nozzle and atomized.
  • the spray-dried flavor is present in the carrier mixture in amounts of about 15 to about 20% by weight of the total carrier and flavor.
  • the carrier solution can be a sucrose solution.
  • the carrier solution can be an aqueous gum arabic solution.
  • the oral composition of the invention can also contain cooling agents and cooling flavors, such as those disclosed in U.S. Patent No. 6,627,233, the disclosure of which is incorporated by reference herein. Cooling agents and flavors are used in chewing gum to improve the "cool" sensation perceived upon chewing the gum and to extend the duration of the "cool” sensation. In chewing gums, adding a cooling agent provides the chewing gum with an unexpected, high-flavor impact. This is particularly valuable for sugarless chewing gum where the harsh notes of an added flavor are not masked by sugar.
  • cooling agents including menthyl succinate; acyclic carboxamide; menthyl lactate; 3-1- menthoxypropane-l,2-diol; N-substituted p-menthane carboxamide; menthone glycerol ketals and mixtures thereof.
  • a cooling agent or combinations of cooling agents can be treated to have a modified-release.
  • the controlled release combination of physiological cooling agents is obtained by modifying the cooling agents by encapsulation, partial encapsulation or partial coating, entrapment or absorption with water-soluble materials or water-insoluble materials.
  • the procedures for modifying the physiological cooling agents include spray drying, spray chilling, fluid-bed coating, coacervation, extrusion, and other agglomerating and standard encapsulating techniques.
  • the cooling agents may also be absorbed onto an inert or water-insoluble material.
  • the cooling agents may be modified in a multiple step process comprising any of the processes noted.
  • the chewing gum is manufactured by sequentially adding the various chewing gum ingredients to a commercially available mixer known in the art. After the ingredients have been thoroughly mixed, the gum mass is discharged from the mixer and shaped into the desired form, such as rolling into sheets and cutting into sticks or tabs, extruding into chunks or casting into pellets, which are then coated or panned.
  • the ingredients are mixed by first melting the gum base and adding it to the running mixer.
  • the base may also be melted in the mixer itself.
  • Color or emulsifiers may also be added at this time.
  • the softener may also be added at this time, along with syrup and a portion of the bulking agent. Further parts of the bulking agent are added to the mixer. Flavoring agents, such as the stress-reducing flavoring agent described above are added with the final portion of the bulking agent.
  • Other optional ingredients are added to the batch in a typical fashion, well known to those of ordinary skill in the art.
  • the entire mixing procedure typically takes from five to fifteen minutes, but longer mixing times may sometimes be required. Those skilled in the art will recognize that many variations of the above described procedure may be followed. [0070] After the ingredients are mixed, the gum mass is either sheeted or formed into pellets or balls. Pellet or ball gum is prepared as conventional chewing gum but formed into pellets that are pillow shaped, or into balls.
  • the pellets/balls can be used as cores for a coated chewing gum product having a core.
  • the cores can be sugar or polyol coated or panned by conventional panning techniques to make a coated pellet gum.
  • the weight of the coating may be about 20% to about 50% of the weight of the finished product, but may be as much as 75% of the total gum product.
  • Conventional panning procedures generally coat with sucrose, but recent advances in panning have allowed use of other carbohydrate materials to be used in place of sucrose.
  • coating materials include, but are not limited to, sugars such as dextrose, maltose, isomaltulose, and tagatose, or sugarless bulk sweeteners such as xylitol, sorbitol, lactitol, hydrogenated isomaltulose, erythritol, maltitol, and other new polyols (also referred to as alditols) or combinations thereof.
  • a preferred coating comprises about 30% to about 75% maltitol.
  • panning modifiers including, but not limited to, gum arabic, gum talha, maltodextrins, corn syrup, gelatin, cellulose type materials like carboxymethyl cellulose or hydroxymethyl cellulose, starch and modified starches, vegetables gums like alginates, locust bean gum, guar gum, and gum tragacanth.
  • Antistick agents may also be added as panning modifiers, which allow the use of a variety of carbohydrates and sugar alcohols.
  • Flavors such as the stress-reducing flavoring agents described above, may also be added with the sugar or sugarless coating to yield unique product characteristics.
  • Table 4 below provides two exemplary chewing gum formulations in accordance with aspects of the invention.
  • Alditol/Glycerin Syrup listed above is a blend of sorbitol solution, hydro genated starch hydrolysate syrup, and glycerin co-evaporated to about 3% moisture.
  • the composition of the Alditol/Glycerin Syrup composition is given below in Table 5. TABLE 5
  • confectionery compositions or products containing stress-reducing flavoring agents can include, for example, hard candies, chewy candies, coated chewy center candies, and tabletted candies.
  • the hard candy is primarily comprised of corn syrup and sugar, and derives its name from the fact that it contains only 1 % and 4% moisture. In appearance, these types of candies are solid, but they are actually supercooled liquids, which are far below their melting points.
  • the solid carrier is sugar or a water soluble polyhydric alcohol (polyol) such as mannitol, xylitol, sorbitol, maltitol, a hydrogenated starch hydrolysate (“Lycasin”), hydrogenated glucose, hydrogenated disaccharides, and/or hydrogenated polysaccharides, as the major ingredient, in an amount of about 85-98% by weight of the total carrier.
  • Solid salts such as sodium bicarbonate, sodium chloride, potassium bicarbonate or potassium chloride may totally or partially replace the polyol carrier.
  • Tableting lubricants in minor amounts of about 0.1 to 5% by weight, may be incorporated into the tablet or lozenge formulation to facilitate the preparation of both the tablets and the lozenges.
  • Suitable lubricants include vegetable oil such as coconut oil, magnesium stearate, aluminum stearate, talc, starch and Carbowax.
  • Lozenge formulations may contain about 2% hydrocolloid as a barrier agent to provide a shiny surface as opposed to a tablet which has a smooth finish.
  • the lozenge or tablet may optionally be coated with a coating material such as waxes, shellacs, carboxymethyl cellulose, polyethylene/maleic anhydride copolymer or Kappa-carrageenan, to further increase the time it takes the tablet or lozenge to dissolve in the mouth.
  • a coating material such as waxes, shellacs, carboxymethyl cellulose, polyethylene/maleic anhydride copolymer or Kappa-carrageenan, to further increase the time it takes the tablet or lozenge to dissolve in the mouth.
  • the coated tablet or lozenge should be slowly dissolving, providing a sustained release rate of the active ingredients over the period of about 3 to about 15 minutes.
  • the stress-reducing flavoring agents of the present invention are incorporated into a lozenge or tablet by conventional mixing and tableting techniques known in this field.
  • the present embodiment of the invention further contemplates the optional inclusion of a sweetener, flavorant, or colorant component into the tablets or lozenges containing stress-reducing flavoring agents.
  • the sweetener component comprises any one or more sweeteners known in the art, including both natural and artificial sweeteners.
  • the sweetener may be chosen from a wide range of materials, including water-soluble sweeteners, water- soluble artificial sweeteners, dipeptide based sweeteners, and mixtures thereof.
  • sweeteners may be chosen from the following non-limiting list, which includes sugars such as sucrose, glucose, corn syrup, dextrose, invert sugar, fructose and mixtures thereof; saccharine and its various salts such as the sodium or calcium salt; cyclamic acid and its various salts such as the sodium salt; free aspartame; dihydrochalcone sweetening compounds; glycyrrhizin; stevioside; monellin; thaumatin; sucralose; isomaltitol; neosugar; lactitol; polydextrose; tagatose; maltitol; and sugar alcohols such as sorbitol, sorbitol syrup, mannitol, xylitol, and the like.
  • sugars such as sucrose, glucose, corn syrup, dextrose, invert sugar, fructose and mixtures thereof
  • saccharine and its various salts such as the sodium or calcium salt
  • sweetener is the nonfermentable sugar substitute hydrogenated starch hydrolysate (also known as Lycasin). Also contemplated is the synthetic sweetener 3,6-dihydro- 6-methyl-l-l,2,3-oxathiazin-4-one-2,2-dioxide, particularly potassium (Acesulfame- K), sodium and calcium salts thereof. Sorbitol is the preferred sweetening and bulking agent. The amount of sweetener included is an amount effective to provide the desired degree of sweetness and bulk, generally 0.001 to 70 weight % of the tablet or lozenge.
  • High intensity artificial sweeteners can also be used, alone or in combination, with the above.
  • Preferred sweeteners include, but are not limited to, sucralose, aspartame, APM derivatives such as neotame, salts of acesulfame, altitame, saccharin and its salts, cyclamic acid and its salts, glycyrrhizinate, dihydrochalcones, thaumatin, monellin, and the like, alone or in combination.
  • Such techniques as wet granulation, wax granulation, spray drying, spray chilling, fluid bed coating, coacervation, and fiber extension may be used to achieve the desired release characteristics.
  • additional flavorants may be included.
  • suitable additional flavorants include natural and artificial flavors, such as menthol, oil of spearmint, oil of cinnamon, oil of wintergreen (methyl salicylate), and various fruit flavors, including but not limited to lemon oil, orange oil, grape flavor, lime oil, grapefruit oil, apple, apricot essence, and combinations thereof.
  • particularly preferred flavors are stress-reducing flavoring agents, such as peppermint, vanilla, and peach.
  • the flavorings are generally utilized in amounts that will vary depending upon the individual flavor, and may, for example, range in amounts of about 0.5% to about 3% by weight of the tablet or lozenge.
  • Colorants can be present in the tablets or lozenges of the present invention.
  • Examples include pigments such as titanium dioxide, natural food colorants such as beta carotenes, betanin, turmeric, and other dyes suitable for food, drug and cosmetic appli cations known as F. D. & C. dyes, and the like.
  • the materials may be incorporated in amounts of up to about 1 % by weight, preferably up to about 6% by weight of the tablet or lozenge.
  • the stress-reducing flavoring agents may be incorporated into an otherwise conventional pressed tablet formulation.
  • the pressed tablet into which the stress- reducing flavoring agents are incorporated may be prepared by wet granulation, dry granulation, and direct compression methods. These methods involve conventional procedures well known to the ordinary skilled artisan.
  • wet granulation involves mixing milled powders, preparing a wet mass by blending the milled powders with a binder solution, coarse screening the wet mass and drying the moist granules, screening the granules through a 14 to 20 mesh screen, mixing the screened granules with lubricants and disintegrate agents and finally tablet compressing the mass.
  • dry granulation generally involves milling of powders, compression into large hard tablets to make slugs, screening of slugs, mixing with lubricants and disintegrating agents and finally tablet compression.
  • direct compression method the milled ingredients are mixed and then merely tabletted by compression.
  • the pressed tablet ingredients used in the invention are selected from those materials routinely used. Such ingredients primarily include sweeteners, lubricants, and optional coloring agents, binders and fillers.
  • Sweetening agents may be selected from a wide range of materials such as water-soluble sweetening agents, water-soluble artificial sweeteners, and dipeptide based sweeteners, including mixtures thereof.
  • Representative illustrations encompass: 1) Water-soluble sweetening agents such as monosaccharides, disaccharides and polysaccharides such as xylose, ribose, glucose, mannose, galactose, lactose, fructose, dextrose, sucrose, sugar, maltose, partially hydrolyzed starch, or corn syrup solids and sugar alcohols such as sorbitol, xylitol, mannitol and mixtures thereof; 2) Water-soluble artificial sweeteners such as the soluble saccharin salts, i.e.
  • Dipeptide based sweeteners include L-aspartyl-L-phenylalanine methyl ester and related compounds.
  • the amount of sweetener will vary with the desired amount of sweetener selected. This amount will normally be about 0.001% to about 98% by weight when using an easily extractable sweetener.
  • the water-soluble sweeteners are preferably used in amounts of about 75% to about 98% by weight, and most preferably about 80% to about 95% by weight of the final tablet composition.
  • the artificial sweeteners are used in amounts of about 0.01% to about 5.0% and most preferably about 0.05% to about 0.25% by weight of the final tablet composition. These amounts are necessary to achieve a desired level of sweetness independent from the flavor level achieved from the flavor oil.
  • Lubricants are used in the tablet formulations in order to ease the ejection of the tablet from the die, to prevent sticking of the tablets to the punches and to limit wear on dies and punches.
  • Tableting lubricants may be selected from a wide range of materials such as magnesium stearate, calcium stearate, zinc stearate, hydrogenated vegetable oils, talc, light mineral oil, sodium benzoate, sodium lauryl sulfate, magnesium lauryl sulfate and mixtures thereof.
  • Magnesium stearate is the preferred lubricant in view of its ready availability and efficient lubrication properties.
  • the lubricants should be in as fine a state of subdivision as possible since the smaller the particle size the greater the efficiency in the granulation. Preferred sizes are those that pass through an 80 or 100 mesh screen and most preferred through a 200 mesh screen before use.
  • the amount of lubricant will vary broadly and is preferably from about 0.1% to about 5% by weight of the total composition.
  • Colorants should be selected from materials that are unaffected by higher temperatures and are considered optional ingredients in the tablet formulations. Such materials when used are employed in amounts of 0 to about 0.03% by weight of the total formulation.
  • Binders that are used when a wet granulation process is employed include starch, pregelatinized starch, gelatin, free polyvinylpyrrolidone, methylcellulose, sodium carboxymethylcellulose, polyvinylalcohols and so forth. Binders when used can be employed in amounts up to about 25% and preferably about 5 to about 15% by weight. Conventional fillers may also be present such as calcium sulfate, dicalcium phosphate, tricalcium phosphate, starch, microcrystalline cellulose and so forth in amounts up to about 50% by weight with preferred amounts from about 5 to 20% by weight of the final formulation.
  • the pressed tablet formulations can be prepared by conventional means using standard techniques and equipment known to those skilled in the art. In one method, stress-reducing flavoring agents are blended with the tablet formulation ingredients. Once incorporated, mixing is continued until a uniform mixture is obtained and thereafter the mixture is formed into suitable shapes by subjecting the formulation to a tableting operation. Compression pressures on the order up to 65 megapascals (approximately 12 tons per square inch) are normally employed.
  • a barrier agent is usually present, preferably in a concentration of up to about 2 weight %.
  • the barrier agent provides a shiny surface as opposed to a tablet which, although having a smooth finish, is usually not shiny.
  • the barrier agent is a hydrocolloid.
  • the oral composition is a lozenge, a tablet, or a pressed tablet
  • these products may be coated with a coating material.
  • coating materials suitable for use in this application are waxes, shellacs, carboxymethyl cellulose, ethylene-maleic anhydride copolymers and carragennan.
  • a coating material is used to increase the time it takes for the tablet or lozenge to dissolve in the mouth.
  • a coated tablet or lozenge is slow dissolving, providing sustained release of the active ingredients over a longer period of time, for example 3 to 15 minutes, or sometimes even longer.

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Abstract

Composition de friandise permettant d'atténuer le stress et l'envie de fumer chez les fumeurs renonçant à fumer. Cette composition comprend au moins un sucre ou un alcool de sucre et une dose efficace d'un agent aromatisant atténuateur de stress. Lorsqu'elle se présente sous la forme de chewing gum, la composition comprend une partie gonflée hydrosoluble et une partie de base insoluble dans l'eau. L'agent aromatisant atténuateur de stress peut inclure un ou plusieurs des parfums suivants : menthe, vanille ou pêcher. Cet agent réduit l'envie de fumer et éventuellement le niveau de cortisol salivaire chez le fumeur qui s'abstient de fumer. Ce procédé permet d'atténuer le stress chez les fumeurs qui renoncent provisoirement à fumer et de réduire la consommation de tabac chez les fumeurs qui espacent leur consommation de tabac.
PCT/US2006/037043 2005-09-30 2006-09-22 Composition orale et technique de diminution du stress associe a l'arret du tabac WO2007041035A2 (fr)

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US60/722,307 2005-09-30

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8017168B2 (en) 2006-11-02 2011-09-13 The Coca-Cola Company High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith
US9101160B2 (en) 2005-11-23 2015-08-11 The Coca-Cola Company Condiments with high-potency sweetener
US10098376B2 (en) 2003-11-07 2018-10-16 U.S. Smokeless Tobacco Company Llc Tobacco compositions
US10945454B2 (en) 2003-11-07 2021-03-16 U.S. Smokeless Tobacco Company Llc Tobacco compositions

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8336557B2 (en) * 2007-11-28 2012-12-25 Philip Morris Usa Inc. Smokeless compressed tobacco product for oral consumption
US9204667B2 (en) * 2010-12-01 2015-12-08 R.J. Reynolds Tobacco Company Smokeless tobacco pastille and injection molding process for forming smokeless tobacco products
US10244786B2 (en) 2013-10-03 2019-04-02 Altria Client Services Llc Tobacco lozenge
US10105320B2 (en) 2013-10-03 2018-10-23 Altria Client Services Soluble fiber lozenge
US11779045B2 (en) 2013-10-03 2023-10-10 Altria Client Services Llc Dissolvable-chewable exhausted-tobacco tablet
US9999243B2 (en) 2013-10-03 2018-06-19 Altria Client Services Llc Exhausted tobacco lozenge
US9351936B2 (en) 2013-10-03 2016-05-31 Altria Client Services Llc Nicotine lozenge
CN106343138A (zh) * 2016-08-30 2017-01-25 四川高福记生物科技有限公司 一种鲜橙风味的乳酸菌压片糖果及其制备方法
GB201807305D0 (en) * 2018-05-03 2018-06-20 Nicoventures Trading Ltd Vaporisable formulation

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5888538A (en) * 1995-03-29 1999-03-30 Warner-Lambert Company Methods and apparatus for making seamless capsules
US20020090445A1 (en) * 2000-09-05 2002-07-11 Laman Alani Flavoring systems for pharmaceutical compositions and methods of making such compositions
US20040151771A1 (en) * 2003-02-04 2004-08-05 Gin Jerry B. Long-lasting, flavored dosage forms for sustained release of beneficial agents within the mouth
WO2006130132A1 (fr) * 2005-05-27 2006-12-07 Cadbury Adams Usa Llc Compositions aromatisees a la vanille et leurs systemes de distribution

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US91218A (en) * 1869-06-15 Improved composition to destroy the appetite for tobacco
US865026A (en) * 1906-12-15 1907-09-03 Ellis Foster Co Masticable tobacco preparation.
US904521A (en) * 1908-04-20 1908-11-24 Carleton Ellis Masticable tobacco substitute.
US1807098A (en) * 1924-08-13 1931-05-26 Regan Safety Devices Co Inc Magnetron circuit controlling apparatus
US3901248A (en) * 1970-07-22 1975-08-26 Leo Ab Chewable smoking substitute composition
ZA726027B (en) * 1972-05-01 1973-05-30 D Woodcraft Anti-smoking chewing gum preparation
US3845217A (en) * 1972-11-16 1974-10-29 Helsingborg L Ab Buffered smoking substitute compositions
US4276890A (en) * 1979-04-11 1981-07-07 Fichera Anthony T Tobacco smoking inhibitor
GB2125699B (en) * 1982-02-22 1986-02-12 Bruss Ni Sanitarno Gigieniches Medicinal preparation having antinicotine effect and method for obtention thereof
US4971806A (en) * 1984-01-31 1990-11-20 Warner-Lambert Company Multi-layered chewing gum composition having different rates of flavor release
US4835162A (en) * 1987-02-12 1989-05-30 Abood Leo G Agonists and antagonists to nicotine as smoking deterents
US4802498A (en) * 1987-07-02 1989-02-07 Warren Ogren Resin-based chewing tobacco
DE3725138A1 (de) * 1987-07-29 1989-02-09 Basf Ag Verfahren zur herstellung keramischer formteile
US4832994A (en) * 1987-09-02 1989-05-23 Fey Michael S Anti-smoking oral composition
US5021457A (en) * 1989-08-09 1991-06-04 Plough Inc. Method for aiding cessation of smoking
US5488962A (en) * 1990-10-10 1996-02-06 Perfetti, S.P.A. Chewing gum which is a substitute for tobacco smoke
US6063401A (en) * 1998-05-06 2000-05-16 M.E. Cody Products, Inc. Plantago major and hypericum perforatum compound for use in treating a tobacco or nicotine habit
US6045825A (en) * 1998-06-17 2000-04-04 M. E. Cody Products, Inc. Plantago major and Piper methysticum compound for use in treating a tobacco or nicotine habit
US6599542B1 (en) * 1998-08-11 2003-07-29 Warner-Lambert Company Non-stick chewing gum base
US6187318B1 (en) * 1998-10-29 2001-02-13 Innovative Chemical Corporation Anti-snoring composition
US6479088B1 (en) * 1998-11-12 2002-11-12 Wm. Wrigley Jr. Company Method for refining peppermint oil
US6497234B1 (en) * 1999-11-22 2002-12-24 Pamela Coy-Herbert Herbal composition as a substitute for tobacco
US6534527B2 (en) * 2000-06-02 2003-03-18 Phytos, Inc. Edible herbal compositions for relieving nicotine craving

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5888538A (en) * 1995-03-29 1999-03-30 Warner-Lambert Company Methods and apparatus for making seamless capsules
US20020090445A1 (en) * 2000-09-05 2002-07-11 Laman Alani Flavoring systems for pharmaceutical compositions and methods of making such compositions
US20040151771A1 (en) * 2003-02-04 2004-08-05 Gin Jerry B. Long-lasting, flavored dosage forms for sustained release of beneficial agents within the mouth
WO2006130132A1 (fr) * 2005-05-27 2006-12-07 Cadbury Adams Usa Llc Compositions aromatisees a la vanille et leurs systemes de distribution

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "STIMOROL FUSION: NIEUWE GENERATIE KAUWGOM" INTERNET CITATION, [Online] 22 September 2005 (2005-09-22), XP002355080 Retrieved from the Internet: URL:http://www.foodnieuws.nl/actueel/produ ctnieuws/archief/stimorol_fusio n_nieuwe_generatie_kauwgom> [retrieved on 2005-11-21] *
C. DAWES, K. KUBIENIEC: "The effects of prolonged gum chewing on salivary flow rate and composition" Archives of Oral Biology, vol. 49, no. 8, August 2004 (2004-08), pages 665-669, XP002426549 Oxford, GB *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10098376B2 (en) 2003-11-07 2018-10-16 U.S. Smokeless Tobacco Company Llc Tobacco compositions
US10765140B2 (en) 2003-11-07 2020-09-08 U.S. Smokeless Tobacco Company Llc Tobacco compositions
US10945454B2 (en) 2003-11-07 2021-03-16 U.S. Smokeless Tobacco Company Llc Tobacco compositions
US9101160B2 (en) 2005-11-23 2015-08-11 The Coca-Cola Company Condiments with high-potency sweetener
US8017168B2 (en) 2006-11-02 2011-09-13 The Coca-Cola Company High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith

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CN101316517A (zh) 2008-12-03
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WO2007041035A3 (fr) 2007-05-24

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