WO2007033959A3 - Use of p-selectin glycoprotein ligand 1 in modulation of hematogenous metastasis of lymphomas - Google Patents

Use of p-selectin glycoprotein ligand 1 in modulation of hematogenous metastasis of lymphomas Download PDF

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Publication number
WO2007033959A3
WO2007033959A3 PCT/EP2006/066490 EP2006066490W WO2007033959A3 WO 2007033959 A3 WO2007033959 A3 WO 2007033959A3 EP 2006066490 W EP2006066490 W EP 2006066490W WO 2007033959 A3 WO2007033959 A3 WO 2007033959A3
Authority
WO
WIPO (PCT)
Prior art keywords
lymphomas
modulation
selectin glycoprotein
glycoprotein ligand
metastasis
Prior art date
Application number
PCT/EP2006/066490
Other languages
French (fr)
Other versions
WO2007033959A2 (en
Inventor
Baetselier Patrick De
Geert Raes
Ghassabeh Gholamre Hassanzadeh
Original Assignee
Vib Vzw
Univ Bruxelles
Baetselier Patrick De
Geert Raes
Ghassabeh Gholamre Hassanzadeh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vib Vzw, Univ Bruxelles, Baetselier Patrick De, Geert Raes, Ghassabeh Gholamre Hassanzadeh filed Critical Vib Vzw
Publication of WO2007033959A2 publication Critical patent/WO2007033959A2/en
Publication of WO2007033959A3 publication Critical patent/WO2007033959A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/178—Lectin superfamily, e.g. selectins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to the use of P-selectin ligand 1 for the modulation of hematogenous metastasis of lymphomas. More specifically, it relates to the use of P-selectin glycoprotein ligan-1 and of molecules that impair the binding of P-selectin ligand in preventing metastasis, preferably metastasis in liver and spleen.
PCT/EP2006/066490 2005-09-19 2006-09-19 Use of p-selectin glycoprotein ligand 1 in modulation of hematogenous metastasis of lymphomas WO2007033959A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05108577 2005-09-19
EP05108577.7 2005-09-19

Publications (2)

Publication Number Publication Date
WO2007033959A2 WO2007033959A2 (en) 2007-03-29
WO2007033959A3 true WO2007033959A3 (en) 2007-11-22

Family

ID=36499205

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/066490 WO2007033959A2 (en) 2005-09-19 2006-09-19 Use of p-selectin glycoprotein ligand 1 in modulation of hematogenous metastasis of lymphomas

Country Status (1)

Country Link
WO (1) WO2007033959A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102630011B1 (en) 2017-01-11 2024-01-26 브리스톨-마이어스 스큅 컴퍼니 PSGL-1 antagonists and their uses
JP7211961B2 (en) 2017-03-14 2023-01-24 ファイヴ プライム セラピューティクス インク Antibody that binds to VISTA at acidic pH

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003013603A1 (en) * 2001-08-03 2003-02-20 Abgenomics Co. Modulators of p-selectin glycoprotein ligand 1
US20040001822A1 (en) * 2000-12-29 2004-01-01 Avigdor Levanon Y1-isolated molecules comprising epitopes containing sulfated moieties, antibodies to such epitopes, and uses thereof
US20040001839A1 (en) * 2000-12-29 2004-01-01 Avigdor Levanon Multimers - isolated molecules comprising epitopes containing sulfated moieties, antibodies to such epitopes, and uses thereof
US20040002450A1 (en) * 2000-12-29 2004-01-01 Janette Lazarovits Y17 - isolated molecules comprising epitopes containing sulfated moieties, antibodies to such epitopes, and uses thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040001822A1 (en) * 2000-12-29 2004-01-01 Avigdor Levanon Y1-isolated molecules comprising epitopes containing sulfated moieties, antibodies to such epitopes, and uses thereof
US20040001839A1 (en) * 2000-12-29 2004-01-01 Avigdor Levanon Multimers - isolated molecules comprising epitopes containing sulfated moieties, antibodies to such epitopes, and uses thereof
US20040002450A1 (en) * 2000-12-29 2004-01-01 Janette Lazarovits Y17 - isolated molecules comprising epitopes containing sulfated moieties, antibodies to such epitopes, and uses thereof
WO2003013603A1 (en) * 2001-08-03 2003-02-20 Abgenomics Co. Modulators of p-selectin glycoprotein ligand 1

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BLOOD. 15 JUN 2005, vol. 105, no. 12, 15 June 2005 (2005-06-15), pages 4800 - 4806, ISSN: 0006-4971 *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; 15 June 2005 (2005-06-15), BÉLANGER SIMON D ET AL: "Role of selectins in the triggering, growth, and dissemination of T-lymphoma cells: implication of L-selectin in the growth of thymic lymphoma.", XP002385398, Database accession no. NLM15705798 *
DE LUCA M ET AL: "A novel cobra venom metalloproteinase, mocarhagin, cleaves a 10-amino acid peptide from the mature N terminus of P-selectin glycoprotein ligand receptor, PSGL-1, and abolishes P-selectin binding", JOURNAL OF BIOLOGICAL CHEMISTRY. (MICROFILMS), AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, 10 November 1995 (1995-11-10), XP002076917 *
FUKUDA M ET AL: "Mucin-type O-glycans and leukosialin", BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE, AMSTERDAM, NL, vol. 1455, no. 2-3, 8 October 1999 (1999-10-08), pages 205 - 217, XP004276907, ISSN: 0925-4439 *
LIM ET AL: "The role of CD24 in various human epithelial neoplasias", PATHOLOGY RESEARCH AND PRACTICE, GUSTAV FISCHER, STUTTGART, DE, vol. 201, no. 7, 31 August 2005 (2005-08-31), pages 479 - 486, XP005020430, ISSN: 0344-0338 *

Also Published As

Publication number Publication date
WO2007033959A2 (en) 2007-03-29

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