WO2007032778A3 - Analyse des interactions entre liaisons au peptide mhc - Google Patents

Analyse des interactions entre liaisons au peptide mhc Download PDF

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Publication number
WO2007032778A3
WO2007032778A3 PCT/US2006/010809 US2006010809W WO2007032778A3 WO 2007032778 A3 WO2007032778 A3 WO 2007032778A3 US 2006010809 W US2006010809 W US 2006010809W WO 2007032778 A3 WO2007032778 A3 WO 2007032778A3
Authority
WO
WIPO (PCT)
Prior art keywords
mhc
arrays
analysis
peptide binding
binding interactions
Prior art date
Application number
PCT/US2006/010809
Other languages
English (en)
Other versions
WO2007032778A2 (fr
Inventor
Umesh S Muchhal
John R Desjarlais
Gregory L Moore
Original Assignee
Xencor Inc
Umesh S Muchhal
John R Desjarlais
Gregory L Moore
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/226,928 external-priority patent/US20060084116A1/en
Application filed by Xencor Inc, Umesh S Muchhal, John R Desjarlais, Gregory L Moore filed Critical Xencor Inc
Publication of WO2007032778A2 publication Critical patent/WO2007032778A2/fr
Publication of WO2007032778A3 publication Critical patent/WO2007032778A3/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56977—HLA or MHC typing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/539—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody involving precipitating reagent, e.g. ammonium sulfate
    • G01N33/541—Double or second antibody, i.e. precipitating antibody
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70539—MHC-molecules, e.g. HLA-molecules

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne des procédés, appareils et composés de recherche systématique ou de détection de la liaison de candidats peptides à une protéine MHC. En l'occurrence, on prend un premier composant comprenant au moins des candidats peptides et un deuxième composant comprenant au moins une protéine MHC, et on les met en contact. L'un des composants est immobilisé sur un support solide. Il ne reste plus qu'à déterminer la présence, l'absence, ou la quantité de liaison et la protéine MHC considérée.
PCT/US2006/010809 2005-09-13 2006-03-23 Analyse des interactions entre liaisons au peptide mhc WO2007032778A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11/226,928 US20060084116A1 (en) 2004-09-13 2005-09-13 Analysis of MHC-peptide binding interactions
US11/226,928 2005-09-13
US72237805P 2005-09-29 2005-09-29
US60/722,378 2005-09-29

Publications (2)

Publication Number Publication Date
WO2007032778A2 WO2007032778A2 (fr) 2007-03-22
WO2007032778A3 true WO2007032778A3 (fr) 2007-05-10

Family

ID=37056886

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/010809 WO2007032778A2 (fr) 2005-09-13 2006-03-23 Analyse des interactions entre liaisons au peptide mhc

Country Status (1)

Country Link
WO (1) WO2007032778A2 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003082197A2 (fr) * 2002-03-22 2003-10-09 Gpc Biotech Ag Composes immunosuppresseurs, methodes et utilisations associees
US20040230380A1 (en) * 2002-01-04 2004-11-18 Xencor Novel proteins with altered immunogenicity
WO2005073248A1 (fr) * 2004-01-30 2005-08-11 King's College London Peptides pour le traitement de maladies auto-immunes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040230380A1 (en) * 2002-01-04 2004-11-18 Xencor Novel proteins with altered immunogenicity
WO2003082197A2 (fr) * 2002-03-22 2003-10-09 Gpc Biotech Ag Composes immunosuppresseurs, methodes et utilisations associees
WO2005073248A1 (fr) * 2004-01-30 2005-08-11 King's College London Peptides pour le traitement de maladies auto-immunes

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GODKIN ANDREW ET AL: "Use of eluted peptide sequence data to identify the binding characteristics of peptides to the insulin-dependent diabetes susceptibility allele HLA-DQ8 (DQ 3.2)", INTERNATIONAL IMMUNOLOGY, vol. 9, no. 6, 1997, pages 905 - 911, XP002419884, ISSN: 0953-8178 *
HAMMER J ET AL: "Precise prediction of majour histocompatibility complex class II-peptide interaction based on peptide side chain scanning", JOURNAL OF EXPERIMENTAL MEDICINE, TOKYO, JP, vol. 180, December 1994 (1994-12-01), pages 2353 - 2358, XP002322265, ISSN: 0022-1007 *
MARSHALL KEITH W ET AL: "Prediction of peptide affinity to HLA DRB1*0401", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 154, no. 11, 1995, pages 5927 - 5933, XP002375653, ISSN: 0022-1767 *

Also Published As

Publication number Publication date
WO2007032778A2 (fr) 2007-03-22

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