WO2007030545A3 - Biodegradable microparticle pharmaceutical formulations exhibiting improved release rates - Google Patents

Biodegradable microparticle pharmaceutical formulations exhibiting improved release rates Download PDF

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Publication number
WO2007030545A3
WO2007030545A3 PCT/US2006/034722 US2006034722W WO2007030545A3 WO 2007030545 A3 WO2007030545 A3 WO 2007030545A3 US 2006034722 W US2006034722 W US 2006034722W WO 2007030545 A3 WO2007030545 A3 WO 2007030545A3
Authority
WO
WIPO (PCT)
Prior art keywords
release rates
pharmaceutical formulations
disk
exhibiting improved
active agents
Prior art date
Application number
PCT/US2006/034722
Other languages
French (fr)
Other versions
WO2007030545A2 (en
Inventor
Eliot M Slovin
Joseph T Persyn
Joseph A Mcdonough
Neal K Vail
Darren E Barlow
Albert M Zwiener
Original Assignee
Southwest Res Inst
Eliot M Slovin
Joseph T Persyn
Joseph A Mcdonough
Neal K Vail
Darren E Barlow
Albert M Zwiener
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/221,337 external-priority patent/US7261529B2/en
Priority claimed from US11/220,807 external-priority patent/US9693967B2/en
Priority claimed from US11/220,430 external-priority patent/US7758778B2/en
Application filed by Southwest Res Inst, Eliot M Slovin, Joseph T Persyn, Joseph A Mcdonough, Neal K Vail, Darren E Barlow, Albert M Zwiener filed Critical Southwest Res Inst
Priority to EP06803043A priority Critical patent/EP1931387A4/en
Priority to CA002621395A priority patent/CA2621395A1/en
Priority to JP2008530171A priority patent/JP2009507845A/en
Priority to AU2006287499A priority patent/AU2006287499A1/en
Priority to BRPI0615563-4A priority patent/BRPI0615563A2/en
Publication of WO2007030545A2 publication Critical patent/WO2007030545A2/en
Publication of WO2007030545A3 publication Critical patent/WO2007030545A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

This invention is directed to an apparatus and method for producing microparticles comprising pharmacologically active agents and biodegradable polymers. The apparatus (100) includes a spinning disk (105) containing a reservoir (708) in the center thereof and a flat inclined surface. The apparatus optionally includes serrations (712) and/or a flat surface beneath the periphery of the disk that is parallel to the rotational axis of the disk. The invention is also directed to a method for producing microparticles containing pharmacologically active agents, using the spinning disk apparatus. Formulations containing ophthalmically active agents are provided. Formulations exhibiting zero order release rates are also described.
PCT/US2006/034722 2005-09-07 2006-09-06 Biodegradable microparticle pharmaceutical formulations exhibiting improved release rates WO2007030545A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP06803043A EP1931387A4 (en) 2005-09-07 2006-09-06 Biodegradable microparticle pharmaceutical formulations exhibiting improved release rates
CA002621395A CA2621395A1 (en) 2005-09-07 2006-09-06 Biodegradable microparticle pharmaceutical formulations exhibiting improved release rates
JP2008530171A JP2009507845A (en) 2005-09-07 2006-09-06 Biodegradable microparticle pharmaceutical formulation with improved release rate
AU2006287499A AU2006287499A1 (en) 2005-09-07 2006-09-06 Biodegradable microparticle pharmaceutical formulations exhibiting improved release rates
BRPI0615563-4A BRPI0615563A2 (en) 2005-09-07 2006-09-06 biodegradable microparticle pharmaceutical formulations exhibiting improved release rates

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US22043105A 2005-09-07 2005-09-07
US22044505A 2005-09-07 2005-09-07
US11/220,807 2005-09-07
US11/221,337 US7261529B2 (en) 2005-09-07 2005-09-07 Apparatus for preparing biodegradable microparticle formulations containing pharmaceutically active agents
US11/220,807 US9693967B2 (en) 2005-09-07 2005-09-07 Biodegradable microparticle pharmaceutical formulations exhibiting improved released rates
US11/220,445 2005-09-07
US11/220,431 2005-09-07
US11/220,430 2005-09-07
US11/221,337 2005-09-07
US11/220,430 US7758778B2 (en) 2005-09-07 2005-09-07 Methods for preparing biodegradable microparticle formulations containing pharmaceutically active agents

Publications (2)

Publication Number Publication Date
WO2007030545A2 WO2007030545A2 (en) 2007-03-15
WO2007030545A3 true WO2007030545A3 (en) 2007-11-08

Family

ID=37836422

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/034722 WO2007030545A2 (en) 2005-09-07 2006-09-06 Biodegradable microparticle pharmaceutical formulations exhibiting improved release rates

Country Status (7)

Country Link
EP (1) EP1931387A4 (en)
JP (1) JP2009507845A (en)
KR (1) KR20080059175A (en)
AU (1) AU2006287499A1 (en)
BR (1) BRPI0615563A2 (en)
CA (1) CA2621395A1 (en)
WO (1) WO2007030545A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2956345B1 (en) * 2010-02-17 2012-02-03 Ab7 Ind PROCESS FOR THE PREPARATION OF BIODEGRADABLE POLYMER GRANULES LOADED WITH ACTIVE LIPOPHILIC COMPOUNDS AND ACTIVE BIODEGRADABLE PRODUCTS OBTAINED
UA111162C2 (en) 2010-08-04 2016-04-11 Флекшен Терап'Ютікс, Інк. INJECTION COMPOSITION OF TRIAMCINOLONE ACETONIDE FOR TREATMENT OF PAIN
EP2613688B1 (en) 2010-10-26 2015-04-08 Alcon Research, Ltd Ophthalmoscopic surgical contact lens
WO2013019280A1 (en) * 2011-08-04 2013-02-07 Flexion Therapeutics Corticosteroids for the treatment of joint pain
EP2897593A4 (en) * 2012-09-20 2016-04-06 Akina Inc Biodegradable microcapsules containing filling material
JP7527562B2 (en) 2020-08-24 2024-08-05 学校法人福岡大学 Manufacturing method of microcapsules

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675140A (en) * 1984-05-18 1987-06-23 Washington University Technology Associates Method for coating particles or liquid droplets
US20050064010A1 (en) * 2003-09-18 2005-03-24 Cooper Eugene R. Transscleral delivery
US20050181023A1 (en) * 2004-02-17 2005-08-18 Young Janel E. Drug-enhanced adhesion prevention

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4256677A (en) * 1976-04-12 1981-03-17 Magnavox Government And Industrial Electronics Co. Apparatus and method for making small spheres
US5643594A (en) * 1992-05-29 1997-07-01 The Regents Of The University Of California Spin encapsulation apparatus and method of use
SE505146C2 (en) * 1995-10-19 1997-06-30 Biogram Ab Particles for delayed release
US5665428A (en) * 1995-10-25 1997-09-09 Macromed, Inc. Preparation of peptide containing biodegradable microspheres by melt process
ES2347045T3 (en) * 2002-11-04 2010-10-25 Ocean Nutrition Canada Limited MICROCAPSULES THAT HAVE MULTIPLE CORTEZAS, AND METHOD FOR THEIR PREPARATION.
JP2006518383A (en) * 2003-02-20 2006-08-10 アルコン，インコーポレイテッド Glucocorticoid formulations for treating pathological ocular angiogenesis
JP4487141B2 (en) * 2003-08-20 2010-06-23 参天製薬株式会社 Drug delivery system for microtenon subcapsular administration
EP1662870A1 (en) * 2003-08-22 2006-06-07 Danisco A/S Encapsulated antimicrobial material

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675140A (en) * 1984-05-18 1987-06-23 Washington University Technology Associates Method for coating particles or liquid droplets
US20050064010A1 (en) * 2003-09-18 2005-03-24 Cooper Eugene R. Transscleral delivery
US20050181023A1 (en) * 2004-02-17 2005-08-18 Young Janel E. Drug-enhanced adhesion prevention

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1931387A4 *

Also Published As

Publication number Publication date
CA2621395A1 (en) 2007-03-15
JP2009507845A (en) 2009-02-26
WO2007030545A2 (en) 2007-03-15
AU2006287499A1 (en) 2007-03-15
EP1931387A4 (en) 2012-07-11
BRPI0615563A2 (en) 2011-05-24
EP1931387A2 (en) 2008-06-18
KR20080059175A (en) 2008-06-26

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