WO2007029156A3 - Isoindoledione derivatives as adrenergic receptor antagonists - Google Patents

Isoindoledione derivatives as adrenergic receptor antagonists Download PDF

Info

Publication number
WO2007029156A3
WO2007029156A3 PCT/IB2006/053082 IB2006053082W WO2007029156A3 WO 2007029156 A3 WO2007029156 A3 WO 2007029156A3 IB 2006053082 W IB2006053082 W IB 2006053082W WO 2007029156 A3 WO2007029156 A3 WO 2007029156A3
Authority
WO
WIPO (PCT)
Prior art keywords
bph
isoindoledione
derivatives
receptor antagonists
adrenergic receptor
Prior art date
Application number
PCT/IB2006/053082
Other languages
French (fr)
Other versions
WO2007029156A2 (en
Inventor
Pakala Kumara Savithru Sarma
Ashani Kuttan
Arani Pal
Atul Kondaskar
Praful Gupta
Sankaranarayanan Dharmarajan
Sandeep Y Shelke
Somesh Sharma
Anita Chugh
Atul Tiwari
Original Assignee
Ranbaxy Lab Ltd
Pakala Kumara Savithru Sarma
Ashani Kuttan
Arani Pal
Atul Kondaskar
Praful Gupta
Sankaranarayanan Dharmarajan
Sandeep Y Shelke
Somesh Sharma
Anita Chugh
Atul Tiwari
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd, Pakala Kumara Savithru Sarma, Ashani Kuttan, Arani Pal, Atul Kondaskar, Praful Gupta, Sankaranarayanan Dharmarajan, Sandeep Y Shelke, Somesh Sharma, Anita Chugh, Atul Tiwari filed Critical Ranbaxy Lab Ltd
Publication of WO2007029156A2 publication Critical patent/WO2007029156A2/en
Publication of WO2007029156A3 publication Critical patent/WO2007029156A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Provided are isoindoledione derivatives, which can be used of treating a disease or disorder mediated through αla and/or α1(1 adrenergic receptors. Compounds disclosed herein can be used of treating benign prostatic hyperplasia (BPH) and related symptoms thereof, lower urinary tract symptoms (LUTS) associated with or without BPH. Processes for the preparation of described compounds, pharmaceutical compositions thereof, and methods of treating BPH and related symptoms thereof, LUTS associated with or without BPH are also provided.
PCT/IB2006/053082 2005-09-05 2006-09-01 Isoindoledione derivatives as adrenergic receptor antagonists WO2007029156A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2369/DEL/2005 2005-09-05
IN2369DE2005 2005-09-05

Publications (2)

Publication Number Publication Date
WO2007029156A2 WO2007029156A2 (en) 2007-03-15
WO2007029156A3 true WO2007029156A3 (en) 2007-09-07

Family

ID=37708296

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/053082 WO2007029156A2 (en) 2005-09-05 2006-09-01 Isoindoledione derivatives as adrenergic receptor antagonists

Country Status (1)

Country Link
WO (1) WO2007029156A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202007422QA (en) 2018-02-05 2020-09-29 Alkermes Inc Compounds for the treatment of pain

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998051298A1 (en) * 1997-05-12 1998-11-19 Ortho-Mcneil Pharmaceutical Inc. Arylsubstituted piperazines useful in the treatement of benign prostatic hyperlasia
US6245773B1 (en) * 1996-05-16 2001-06-12 Synaptic Pharmaceutical Corporation 5-(heterocyclic alkyl)-6-aryl-dihydropyrimidines
WO2002044151A1 (en) * 2000-11-30 2002-06-06 Ranbaxy Laboratories Limited 1,4-disubstituted piperazine derivatives useful as uro-selective $g(a)1-adrenoceptor blockers
WO2003084928A1 (en) * 2002-04-08 2003-10-16 Ranbaxy Laboratories Limited Alpha, omega-dicarboximide derivatives as useful uro-selective α1α adrenoceptor blockers
WO2005037281A1 (en) * 2003-10-15 2005-04-28 Ranbaxy Laboratories Limited 1-alkylpiperazinyl-pyrrolidin-2, 5-dione derivatives as adrenergic receptor antagonist

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6245773B1 (en) * 1996-05-16 2001-06-12 Synaptic Pharmaceutical Corporation 5-(heterocyclic alkyl)-6-aryl-dihydropyrimidines
WO1998051298A1 (en) * 1997-05-12 1998-11-19 Ortho-Mcneil Pharmaceutical Inc. Arylsubstituted piperazines useful in the treatement of benign prostatic hyperlasia
WO2002044151A1 (en) * 2000-11-30 2002-06-06 Ranbaxy Laboratories Limited 1,4-disubstituted piperazine derivatives useful as uro-selective $g(a)1-adrenoceptor blockers
WO2003084928A1 (en) * 2002-04-08 2003-10-16 Ranbaxy Laboratories Limited Alpha, omega-dicarboximide derivatives as useful uro-selective α1α adrenoceptor blockers
WO2005037281A1 (en) * 2003-10-15 2005-04-28 Ranbaxy Laboratories Limited 1-alkylpiperazinyl-pyrrolidin-2, 5-dione derivatives as adrenergic receptor antagonist
WO2005037282A1 (en) * 2003-10-15 2005-04-28 Ranbaxy Laboratories Limited 1-alkylpiperazinyl-pyrrolidin-2,5-dione derivatives as adrenergic receptor antagonists

Also Published As

Publication number Publication date
WO2007029156A2 (en) 2007-03-15

Similar Documents

Publication Publication Date Title
WO2005074598A3 (en) Nitroxyl progenitor compounds and methods of use
WO2007022257A3 (en) Monocyclic and bicyclic compounds and methods of use
WO2006009734A8 (en) Gonadotropin releasing hormone receptor antagonists
CA2334460A1 (en) Pharmaceutical compositions comprising alpha-adrenoceptor antagonists and muscarinic antagonists
WO2006113140A3 (en) Novel compounds useful for bradykinin b1 receptor antagonism
WO2007076070A3 (en) Modulators of muscarinic receptors
WO2007044804A3 (en) Piperidine derivatives and methods of use
WO2006044504A8 (en) Cgrp receptor antagonists
WO2008082613A3 (en) Factor ix moiety-polymer conjugates having a releasable linkage
WO2009140642A3 (en) Tricyclic antagonists of prostaglandin d2 receptors
WO2005117872A3 (en) Dual acting snri-nmda antagonists for the treatment of genitourinary disorders
WO2006099268A3 (en) Cgrp receptor antagonists
WO2006007540A3 (en) Piperidine derivatives as nk1 antagonists
WO2007039075A3 (en) Pde inhibitors and combinations thereof for the treatment of urological disorders
WO2006047196A3 (en) Cgrp receptor antagonists
WO2006023852A3 (en) Modulators of muscarinic receptors
WO2006096487A3 (en) Methods and compositions for modulating tweak and fn14 activity
WO2005112916A3 (en) Bis-aryl sulfonamides
WO2005069994A3 (en) Folate conjugates and complexes
WO2007061692A3 (en) Spirolactam tricyclic cgrp receptor antagonists
WO2007025303A3 (en) Non-steroidal antiandrogens
WO2006035282A3 (en) Muscarinic receptor antagonists
WO2006058294A3 (en) Modulators of muscarinic receptors
DK1551803T3 (en) Azabicyclo derivatives as muscarinic receptor antagonists
WO2007146349A3 (en) Cgrp receptor antagonists

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 06795885

Country of ref document: EP

Kind code of ref document: A2