WO2007026255A3 - Dedifferentiated cells and methods of making and using dedifferentiated cells - Google Patents

Dedifferentiated cells and methods of making and using dedifferentiated cells Download PDF

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Publication number
WO2007026255A3
WO2007026255A3 PCT/IB2006/003302 IB2006003302W WO2007026255A3 WO 2007026255 A3 WO2007026255 A3 WO 2007026255A3 IB 2006003302 W IB2006003302 W IB 2006003302W WO 2007026255 A3 WO2007026255 A3 WO 2007026255A3
Authority
WO
WIPO (PCT)
Prior art keywords
cells
dedifferentiated cells
methods
making
dedifferentiated
Prior art date
Application number
PCT/IB2006/003302
Other languages
French (fr)
Other versions
WO2007026255A2 (en
Inventor
Taranger Christel Freberg
Philippe Collas
Original Assignee
Uni I Oslo
Taranger Christel Freberg
Philippe Collas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uni I Oslo, Taranger Christel Freberg, Philippe Collas filed Critical Uni I Oslo
Publication of WO2007026255A2 publication Critical patent/WO2007026255A2/en
Publication of WO2007026255A3 publication Critical patent/WO2007026255A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/70—Undefined extracts
    • C12N2500/80—Undefined extracts from animals
    • C12N2500/84—Undefined extracts from animals from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/30—Coculture with; Conditioned medium produced by tumour cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Transplantation (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention provides methods of making dedifferentiated cells from differentiated cells. The methods comprise treating the differentiated cell with a pluripotent stem cell extract. Dedifferentiated cells, pluripotent stem cells, and reprogrammed cells are also provided, as are methods of treating or preventing a disease, disorder, or condition in a mammal using the cells.
PCT/IB2006/003302 2005-06-22 2006-06-22 Dedifferentiated cells and methods of making and using dedifferentiated cells WO2007026255A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69257305P 2005-06-22 2005-06-22
US60/692,573 2005-06-22

Publications (2)

Publication Number Publication Date
WO2007026255A2 WO2007026255A2 (en) 2007-03-08
WO2007026255A3 true WO2007026255A3 (en) 2008-01-03

Family

ID=37809248

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/003302 WO2007026255A2 (en) 2005-06-22 2006-06-22 Dedifferentiated cells and methods of making and using dedifferentiated cells

Country Status (1)

Country Link
WO (1) WO2007026255A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2659945C (en) * 2005-08-03 2014-12-16 Advanced Cell Technology, Inc. Improved methods of reprogramming animal somatic cells
US8278104B2 (en) 2005-12-13 2012-10-02 Kyoto University Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
BRPI0619794B8 (en) 2005-12-13 2022-06-14 Univ Kyoto Use of a reprogramming factor, agent for preparing an induced pluripotent stem cell from a somatic cell and methods for preparing an induced pluripotent stem cell method and for preparing a somatic cell and use of induced pluripotent stem cells
US8129187B2 (en) 2005-12-13 2012-03-06 Kyoto University Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2
JP2008307007A (en) 2007-06-15 2008-12-25 Bayer Schering Pharma Ag Human pluripotent stem cell induced from human tissue-originated undifferentiated stem cell after birth
US9213999B2 (en) 2007-06-15 2015-12-15 Kyoto University Providing iPSCs to a customer
US20120282229A1 (en) * 2007-08-01 2012-11-08 Christian Kannemeier Non-viral delivery of transcription factors that reprogram human somatic cells into a stem cell-like state
WO2009023161A1 (en) * 2007-08-10 2009-02-19 University Of Dayton Methods of producing pluripotent stem-like cells
US20090180996A1 (en) * 2007-11-09 2009-07-16 Zeki Beyhan Epigenetic modification of cell phenotype, fate and/or function by RNA transfer
KR101532442B1 (en) 2007-12-10 2015-06-29 고쿠리츠 다이가쿠 호진 교토 다이가쿠 Efficient method for nuclear reprogramming
US9683232B2 (en) 2007-12-10 2017-06-20 Kyoto University Efficient method for nuclear reprogramming
ES2722198T3 (en) 2008-05-02 2019-08-08 Univ Kyoto Nuclear reprogramming method
US20140004512A1 (en) * 2010-10-11 2014-01-02 Peter Wernet Quality determination of stem cells
WO2013008803A1 (en) 2011-07-11 2013-01-17 国立大学法人 熊本大学 Method for producing pluripotent cell using bacterium having fermentation ability
WO2013010045A1 (en) 2011-07-12 2013-01-17 Biotime Inc. Novel methods and formulations for orthopedic cell therapy
WO2024050547A2 (en) * 2022-09-02 2024-03-07 Hunterian Medicine Llc Compact bidirectional promoters for gene expression
WO2024123773A1 (en) * 2022-12-06 2024-06-13 University Of South Florida Rna aptamer targeting of adam8 in cancer growth and metastasis

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000049138A2 (en) * 1999-02-20 2000-08-24 Intercytex Limited Pluripotential cells derived from embryonal teratocarcinoma cells and the nucleus of stomatic cells
WO2001000650A1 (en) * 1999-06-30 2001-01-04 Advanced Cell Technology, Inc. Cytoplasmic transfer to de-differentiate recipient cells
WO2002057415A2 (en) * 2000-12-22 2002-07-25 Nucleotech, Llc Method for altering cell fate
WO2002097065A2 (en) * 2001-05-31 2002-12-05 Intercytex Limited Remodeling of somatic nuclei upon addition of pluripotent cell extracts

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000049138A2 (en) * 1999-02-20 2000-08-24 Intercytex Limited Pluripotential cells derived from embryonal teratocarcinoma cells and the nucleus of stomatic cells
WO2001000650A1 (en) * 1999-06-30 2001-01-04 Advanced Cell Technology, Inc. Cytoplasmic transfer to de-differentiate recipient cells
WO2002057415A2 (en) * 2000-12-22 2002-07-25 Nucleotech, Llc Method for altering cell fate
WO2002097065A2 (en) * 2001-05-31 2002-12-05 Intercytex Limited Remodeling of somatic nuclei upon addition of pluripotent cell extracts

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
COLLAS PHILIPPE ET AL: "Epigenetic reprogramming of nuclei using cell extracts", STEM CELL REVIEWS, vol. 2, no. 4, 2006, pages 309 - 317, XP009090348, ISSN: 1550-8943(print) 1558-6804(ele *
HANSIS C ET AL: "Nuclear Reprogramming of Human Somatic Cells by Xenopus Egg Extract Requires BRG1", CURRENT BIOLOGY, CURRENT SCIENCE,, GB, vol. 14, no. 16, 24 August 2004 (2004-08-24), pages 1475 - 1480, XP004548528, ISSN: 0960-9822 *
TARANGER C K ET AL: "Induction of dedifferentiation, genomewide transcriptional programming, and epigenetic reprogramming by extracts of carcinoma and embryonic stem cells", MOLECULAR BIOLOGY OF THE CELL, vol. 16, no. 12, December 2005 (2005-12-01), pages 5719 - 5735, XP002455564, ISSN: 1059-1524 *

Also Published As

Publication number Publication date
WO2007026255A2 (en) 2007-03-08

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