WO2007026182A1 - Fluid exchange catheter system - Google Patents

Fluid exchange catheter system Download PDF

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Publication number
WO2007026182A1
WO2007026182A1 PCT/GR2006/000043 GR2006000043W WO2007026182A1 WO 2007026182 A1 WO2007026182 A1 WO 2007026182A1 GR 2006000043 W GR2006000043 W GR 2006000043W WO 2007026182 A1 WO2007026182 A1 WO 2007026182A1
Authority
WO
WIPO (PCT)
Prior art keywords
catheter
fluid
aspiration
fluid exchange
tip
Prior art date
Application number
PCT/GR2006/000043
Other languages
French (fr)
Inventor
Christos Panotopoulos
Original Assignee
Estelle Enterprises Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to PL06779670T priority Critical patent/PL1937329T3/en
Priority to EP06779670A priority patent/EP1937329B9/en
Application filed by Estelle Enterprises Limited filed Critical Estelle Enterprises Limited
Priority to ES06779670T priority patent/ES2375976T3/en
Priority to RS20120008A priority patent/RS52242B/en
Priority to CN2006800319909A priority patent/CN101252958B/en
Priority to US12/065,019 priority patent/US8398581B2/en
Priority to CA2621557A priority patent/CA2621557C/en
Priority to DK06779670.6T priority patent/DK1937329T5/en
Priority to AU2006286340A priority patent/AU2006286340B2/en
Priority to AT06779670T priority patent/ATE529144T1/en
Priority to JP2008528586A priority patent/JP4875086B2/en
Publication of WO2007026182A1 publication Critical patent/WO2007026182A1/en
Priority to HR20120050T priority patent/HRP20120050T1/en
Priority to US13/769,524 priority patent/US9623177B2/en
Priority to US15/489,006 priority patent/US10293105B2/en
Priority to US16/415,426 priority patent/US11123483B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/71—Suction drainage systems
    • A61M1/77—Suction-irrigation systems
    • A61M1/772—Suction-irrigation systems operating alternately
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A61M25/0026—Multi-lumen catheters with stationary elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/71—Suction drainage systems
    • A61M1/77—Suction-irrigation systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
    • A61M25/007—Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16804—Flow controllers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/84—Drainage tubes; Aspiration tips
    • A61M1/85—Drainage tubes; Aspiration tips with gas or fluid supply means, e.g. for supplying rinsing fluids or anticoagulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A61M25/0026—Multi-lumen catheters with stationary elements
    • A61M2025/0039—Multi-lumen catheters with stationary elements characterized by lumina being arranged coaxially

Definitions

  • the proposed invention is a catheter's system that can be used for infusion of fluids (drugs, water and nutrients) to the body, with concurrent aspiration of biological material (blood, pus, pathological tissue, toxic substances) from the body, in human and, or, animal tissue, without any blockage problems.
  • fluids drug, water and nutrients
  • biological material blood, pus, pathological tissue, toxic substances
  • catheters which are used for fluid infusion and aspiration in a clinical or preclinical setting.
  • catheters which are used for fluid infusion and aspiration in a clinical or preclinical setting.
  • distal the catheter's tip that is inserted in biological material
  • proximal the tip that stays outside
  • the common intravenous catheter either aspirates blood samples - usually immediately after it's insertion to the vein - or infuses solutions of drugs and, or, nutrients - usually for many hours or days following insertion.
  • catheters can infuse or aspirate large quantities of liquids, but they cannot do it concurrently in order to have a constant exchange of drugs and nutrients with the extra-cellular fluid or pathological liquid accumulations of the tissue.
  • the concurrent fluid exchange is desirable both for monitoring and therapeutic reasons.
  • the microdialysis catheter after it's introduction to a human or animal tissue, is continuously perfused with liquid solutions from a pump connected to its proximal tip.
  • the catheter consists of two concentric lumina-tubes, that are covered at their distal tip by a membrane.
  • the central tube is the efferent and the peripheral tube is the afferent part of the catheter.
  • Part of the perfused liquid is infused to the tissue through the catheter's membrane at its distal end, and extracellular fluid is aspirated through the same membrane and the efferent lumen.
  • the endotherapy catheter system claims to possess the desired liquid exchange rate and blockage free operation through a moving part.
  • the infusing tube is appropriately connected to a moving device that irrigates the surrounding the catheter space, while simultaneously propels with its movement the aspiration through the other tube.
  • the proposed invention's fluid exchange catheter system consists of two or more lumens - tubes (1,2), connected properly to infusion (E) and aspiration (A) devices at their proximal tips, and having a filter or membrane or grid or mesh cage or no covering over their distal tips (O).
  • infusion and aspiration devices periodically and, or, continuously change liquid pressure gradients in the system (nevertheless assuring a flow rate that meets the needs for infusion and aspiration of the underlying pathology, or the monitoring, or therapeutic, or research protocol's, needs), in order to create fluid currents (B) that wash clean the catheter's tip and keep unobstructed the fluid exchange between the catheter and the tissue, without the need of any moving parts.
  • the pressure differences in the system are created by any pattern of positive pressures of the infusing pump and the accordingly synchronized pattern of negative pressures of the aspirating pump (pressures always refer to the pressure at the catheter's tip surrounding tissue).
  • pressures always refer to the pressure at the catheter's tip surrounding tissue.
  • a peristaltic pump (E) is programmed to infuse the liquid with a +200 mmHg pressure for 5 sec followed by 10 sec of stop, while the aspirating tube is blocked (N), and a peristaltic pump (A) is programmed to aspirate with a - 100 mmHg pressure during the next 15 sec, while the infusing tube is blocked (N), in a 30 sec cycle of operation.
  • the infusion and aspiration devices of the system can be fluid containers (E, A), simply using the hydrostatic pressure forces created by their position relative to the catheter's tip, as moving forces for the infused fluid to enter and the aspirated fluid to leave the tissue at the catheter's insertion site.
  • Any mode of synchronized changes of pressure at any point of the fluid exchange catheter's system is transferred directly at the infusing and aspirating tip of the catheter through the liquid column of infused or aspirated fluids.
  • the attached designs 1 and 2 represent some of the many possible variations of the fluid exchange catheter's system.
  • the fluid exchange catheter has a bifurcation part of any configuration, in order to split the two opposite flows in two different lumina.
  • the distal end of the outer lumen - tube holds an exchange surface, that can be a filter or membrane or grid or mesh cage or nothing - just the open tip of the aspirating lumen.
  • Fluid which can vary from distilled water to nutrient solutions with drugs, that is supplied through the infusion device (E) to the inner lumen - tube (1), reaches the distal end of the catheter (O), where substance exchange occurs between the infused fluid and substances contained in the surrounding tissue's extracellular fluid.
  • the fluid mixture returns to an aspiration device or collection tank (A). Arrows represent pressure gradients.
  • a fluid jet receiving its supply from the inner lumen's hole(s), is dispersed against the liquid exchange surface's inner wall periodically, unblocking thus the membrane or mesh or grid or filter covering.
  • the jet from the infusing lumen unblocks the aspirating lumen.
  • the construction material of the catheter's system should be in conformity to the norms and regulations existing for clinical and laboratory catheters, including biocompatibility issues etc.

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Biophysics (AREA)
  • External Artificial Organs (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

The proposed invention is a catheter's system that can be used for concurrent fluid infusion and aspiration in humans, animals and biological material, at a wide range of flow rates, without any blockage problems. The proposed system has devices that control the infused liquid's pressure changes accordingly to the aspirated liquid's pressure changes, in order to allow accurate and safe fluid exchange flow control and create changes of pressures at the catheter's tip that do not allow the catheter's blockage.

Description

Fluid exchange catheter system
The proposed invention is a catheter's system that can be used for infusion of fluids (drugs, water and nutrients) to the body, with concurrent aspiration of biological material (blood, pus, pathological tissue, toxic substances) from the body, in human and, or, animal tissue, without any blockage problems.
There are many kinds of catheters which are used for fluid infusion and aspiration in a clinical or preclinical setting. Traditionally, the catheter's tip that is inserted in biological material, is called "distal" and the tip that stays outside is called "proximal".
Most of existing catheters have a single lumen and through this lumen the user can alternatively infuse or aspirate liquids.
For example, in a clinical setting, the common intravenous catheter either aspirates blood samples - usually immediately after it's insertion to the vein - or infuses solutions of drugs and, or, nutrients - usually for many hours or days following insertion.
These catheters can infuse or aspirate large quantities of liquids, but they cannot do it concurrently in order to have a constant exchange of drugs and nutrients with the extra-cellular fluid or pathological liquid accumulations of the tissue.
The concurrent fluid exchange is desirable both for monitoring and therapeutic reasons.
There are few catheters with multiple lumina, which can concurrently infuse and aspirate liquids. For example, the microdialysis catheter after it's introduction to a human or animal tissue, is continuously perfused with liquid solutions from a pump connected to its proximal tip. The catheter consists of two concentric lumina-tubes, that are covered at their distal tip by a membrane. Usually the central tube is the efferent and the peripheral tube is the afferent part of the catheter. Part of the perfused liquid is infused to the tissue through the catheter's membrane at its distal end, and extracellular fluid is aspirated through the same membrane and the efferent lumen.
Microdialysis catheters and similar to them catheters though, were designed for tissue monitoring, and the above described concurrent infusion and aspiration takes place at a few microliter/minute rate flow range and through very small membrane pores.
For therapeutic applications we need much greater liquid exchange rate and membranes or cages with big pores so that it is possible to evacuate low viscosity liquids like pus, that block all existing catheters.
A common problem of all kinds of existing catheters for biological fluids, is their blockage, due to corking of biological material into their lumen's tip or it's covering. For example, the endotherapy catheter system claims to possess the desired liquid exchange rate and blockage free operation through a moving part.
It consists of two concentrical tubes, one infusing and one aspirating, connected properly to infusion and aspiration devices at their proximal tip, and having a filter or membrane or grid or mesh cage covering their distal tip, which contains an hydrodynamically moving device for concurrent infusion and aspiration. The infusing tube is appropriately connected to a moving device that irrigates the surrounding the catheter space, while simultaneously propels with its movement the aspiration through the other tube. The following documents are considered the most relevant state of the art as mentioned above:
Dl: US-A-4 694 832 (UNGERSTEDT CARL U) 22 September 1987 D2: US 4 755 175 A (NILSSON LEIF) 5 July 1988
D3: PCT/GR2004/000045, IPC A61M 25/00, (PANOTOPOULOS CHRISTOS), 8 September 2003.
The proposed invention's fluid exchange catheter system consists of two or more lumens - tubes (1,2), connected properly to infusion (E) and aspiration (A) devices at their proximal tips, and having a filter or membrane or grid or mesh cage or no covering over their distal tips (O). These infusion and aspiration devices periodically and, or, continuously change liquid pressure gradients in the system (nevertheless assuring a flow rate that meets the needs for infusion and aspiration of the underlying pathology, or the monitoring, or therapeutic, or research protocol's, needs), in order to create fluid currents (B) that wash clean the catheter's tip and keep unobstructed the fluid exchange between the catheter and the tissue, without the need of any moving parts.
The pressure differences in the system are created by any pattern of positive pressures of the infusing pump and the accordingly synchronized pattern of negative pressures of the aspirating pump (pressures always refer to the pressure at the catheter's tip surrounding tissue). The system allows a fully and safely controllable infusion-aspiration rate and unobstructed fluid exchange.
For example, in one of the many possible system's versions regarding construction and operational mode, a peristaltic pump (E) is programmed to infuse the liquid with a +200 mmHg pressure for 5 sec followed by 10 sec of stop, while the aspirating tube is blocked (N), and a peristaltic pump (A) is programmed to aspirate with a - 100 mmHg pressure during the next 15 sec, while the infusing tube is blocked (N), in a 30 sec cycle of operation.
Lots of patterns of pressure changes can be applied depending on the underlying pathology or the research protocol. Both these (infusion and aspiration) pressures at the ends of the system, can be monitored to be kept synchronized into a predetermined range and phase difference and can be protected by alarms and automatic stops (N), whenever there is any system's dysfunction detection, by flow and, or, pressure detector devices (N) placed appropriately in the system for safety (against over-infusion, over-aspiration etc).
Alternatively the infusion and aspiration devices of the system can be fluid containers (E, A), simply using the hydrostatic pressure forces created by their position relative to the catheter's tip, as moving forces for the infused fluid to enter and the aspirated fluid to leave the tissue at the catheter's insertion site.
For this version of the fluid exchange catheter's system, we could simply include only one automatic button (N) programmed to compress the aspirating (and infusing) tube for 5 sec, followed by 5 sec of free flow of the aspirated (and infused) fluid or programmed for any other pattern of time intervals for free and blocked flow.
Any mode of synchronized changes of pressure at any point of the fluid exchange catheter's system, is transferred directly at the infusing and aspirating tip of the catheter through the liquid column of infused or aspirated fluids.
The attached designs 1 and 2 represent some of the many possible variations of the fluid exchange catheter's system.
The fluid exchange catheter has a bifurcation part of any configuration, in order to split the two opposite flows in two different lumina.
The distal end of the outer lumen - tube holds an exchange surface, that can be a filter or membrane or grid or mesh cage or nothing - just the open tip of the aspirating lumen.
Fluid, which can vary from distilled water to nutrient solutions with drugs, that is supplied through the infusion device (E) to the inner lumen - tube (1), reaches the distal end of the catheter (O), where substance exchange occurs between the infused fluid and substances contained in the surrounding tissue's extracellular fluid. The fluid mixture returns to an aspiration device or collection tank (A). Arrows represent pressure gradients.
In order to remove organic substances that are built up on the exchange surface, and consequently block the catheter, a fluid jet, receiving its supply from the inner lumen's hole(s), is dispersed against the liquid exchange surface's inner wall periodically, unblocking thus the membrane or mesh or grid or filter covering. When just the open tip of the aspirating lumen is the exchange surface, the jet from the infusing lumen unblocks the aspirating lumen.
The construction material of the catheter's system should be in conformity to the norms and regulations existing for clinical and laboratory catheters, including biocompatibility issues etc.

Claims

Claims
1) Fluid exchange catheter system that comprises infusion (E) and aspiration (A) devices connected appropriately to a catheter that has two or more lumina (1,2), wherein the system includes a mechanism (E,A,N) that creates appropriately programmable changes of pressure in the infusing (1) and aspirating (2) lumen of the catheter, in order to allow the infused fluids to mix with the biological fluids and in order to evacuate this fluid mixture without catheter blockage.
PCT/GR2006/000043 2005-09-02 2006-08-25 Fluid exchange catheter system WO2007026182A1 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
AU2006286340A AU2006286340B2 (en) 2005-09-02 2006-08-25 Fluid exchange catheter system
DK06779670.6T DK1937329T5 (en) 2005-09-02 2006-08-25 Fluid exchange catheter system
ES06779670T ES2375976T3 (en) 2005-09-02 2006-08-25 CATHETER SYSTEM FOR FLUID EXCHANGE.
EP06779670A EP1937329B9 (en) 2005-09-02 2006-08-25 Fluid exchange catheter system
CN2006800319909A CN101252958B (en) 2005-09-02 2006-08-25 Fluid exchange catheter system
US12/065,019 US8398581B2 (en) 2005-09-02 2006-08-25 Fluid exchange catheter system
AT06779670T ATE529144T1 (en) 2005-09-02 2006-08-25 FLUID EXCHANGE CATHETER SYSTEM
PL06779670T PL1937329T3 (en) 2005-09-02 2006-08-25 Fluid exchange catheter system
RS20120008A RS52242B (en) 2005-09-02 2006-08-25 Fluid exchange catheter system
CA2621557A CA2621557C (en) 2005-09-02 2006-08-25 Fluid exchange catheter system
JP2008528586A JP4875086B2 (en) 2005-09-02 2006-08-25 Fluid exchange catheter system
HR20120050T HRP20120050T1 (en) 2005-09-02 2012-01-16 Fluid exchange catheter system
US13/769,524 US9623177B2 (en) 2005-09-02 2013-02-18 Fluid exchange catheter system
US15/489,006 US10293105B2 (en) 2005-09-02 2017-04-17 Fluid exchange catheter system
US16/415,426 US11123483B2 (en) 2005-09-02 2019-05-17 Fluid exchange catheter system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GR20050100452A GR20050100452A (en) 2005-09-02 2005-09-02 Fluid exchange catheter's system
GRGR20050100452 2005-09-02

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/065,019 A-371-Of-International US8398581B2 (en) 2005-09-02 2006-08-25 Fluid exchange catheter system
US13/769,524 Division US9623177B2 (en) 2005-09-02 2013-02-18 Fluid exchange catheter system

Publications (1)

Publication Number Publication Date
WO2007026182A1 true WO2007026182A1 (en) 2007-03-08

Family

ID=37401228

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GR2006/000043 WO2007026182A1 (en) 2005-09-02 2006-08-25 Fluid exchange catheter system

Country Status (17)

Country Link
US (4) US8398581B2 (en)
EP (1) EP1937329B9 (en)
JP (1) JP4875086B2 (en)
CN (1) CN101252958B (en)
AT (1) ATE529144T1 (en)
AU (1) AU2006286340B2 (en)
CA (1) CA2621557C (en)
CY (1) CY1112308T1 (en)
DK (1) DK1937329T5 (en)
ES (1) ES2375976T3 (en)
GR (1) GR20050100452A (en)
HR (1) HRP20120050T1 (en)
PL (1) PL1937329T3 (en)
PT (1) PT1937329E (en)
RS (1) RS52242B (en)
RU (1) RU2449810C2 (en)
WO (1) WO2007026182A1 (en)

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EP2514474A1 (en) 2011-03-28 2012-10-24 Micrel Medical Devices S.A. Fluid exchange system for medical use
WO2013177043A1 (en) * 2012-05-21 2013-11-28 Sinuwave Technologies, Inc. Catheter for photodynamic therapy
EP2695632A1 (en) * 2012-08-10 2014-02-12 Irras AB Fluid exchange catheter and process for unblocking a fluid exchange catheter

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US9510854B2 (en) 2008-10-13 2016-12-06 Boston Scientific Scimed, Inc. Thrombectomy catheter with control box having pressure/vacuum valve for synchronous aspiration and fluid irrigation
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US8979823B2 (en) 2011-02-09 2015-03-17 Apnicure, Inc. Saliva management system with continuous flow through oral device
US8721595B2 (en) 2012-05-11 2014-05-13 Stiehl Technologies, Llc Surgical suction wand
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