WO2007025248A3 - Aggrecanase structure - Google Patents

Aggrecanase structure Download PDF

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Publication number
WO2007025248A3
WO2007025248A3 PCT/US2006/033498 US2006033498W WO2007025248A3 WO 2007025248 A3 WO2007025248 A3 WO 2007025248A3 US 2006033498 W US2006033498 W US 2006033498W WO 2007025248 A3 WO2007025248 A3 WO 2007025248A3
Authority
WO
WIPO (PCT)
Prior art keywords
aggrecanase
ligand complexes
polypeptide
crystals
polypeptides
Prior art date
Application number
PCT/US2006/033498
Other languages
French (fr)
Other versions
WO2007025248A2 (en
WO2007025248B1 (en
Inventor
Lidia Mosyak
Iii Thomas Saltmarsh Rush
Xiaotian Zhong
Thomas E Mcdonagh
Katy E Georgiadis
Phaik-Eng Sum
Edward R Lavallie
Lisa A Collins-Racie
Christopher John Corcoran
Ravindra Kumar
Tracy Hebert
Stephane Hubert Olland
Stewart Andrews Mackie
Original Assignee
Wyeth Corp
Lidia Mosyak
Iii Thomas Saltmarsh Rush
Xiaotian Zhong
Thomas E Mcdonagh
Katy E Georgiadis
Phaik-Eng Sum
Edward R Lavallie
Lisa A Collins-Racie
Christopher John Corcoran
Ravindra Kumar
Tracy Hebert
Stephane Hubert Olland
Stewart Andrews Mackie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp, Lidia Mosyak, Iii Thomas Saltmarsh Rush, Xiaotian Zhong, Thomas E Mcdonagh, Katy E Georgiadis, Phaik-Eng Sum, Edward R Lavallie, Lisa A Collins-Racie, Christopher John Corcoran, Ravindra Kumar, Tracy Hebert, Stephane Hubert Olland, Stewart Andrews Mackie filed Critical Wyeth Corp
Priority to JP2008528233A priority Critical patent/JP2009508474A/en
Priority to CA002619521A priority patent/CA2619521A1/en
Priority to BRPI0616729-2A priority patent/BRPI0616729A2/en
Priority to AU2006282798A priority patent/AU2006282798A1/en
Priority to MX2008002323A priority patent/MX2008002323A/en
Priority to EP06824853A priority patent/EP1917354A2/en
Publication of WO2007025248A2 publication Critical patent/WO2007025248A2/en
Publication of WO2007025248A3 publication Critical patent/WO2007025248A3/en
Publication of WO2007025248B1 publication Critical patent/WO2007025248B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Genetics & Genomics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

This invention relates to aggrecanase polypeptides and aggrecanase polypeptide/ligand complexes, crystals of aggrecanase and aggrecanase polypeptide/ligand complexes, and related methods and software systems.
PCT/US2006/033498 2005-08-25 2006-08-24 Aggrecanase structure WO2007025248A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2008528233A JP2009508474A (en) 2005-08-25 2006-08-24 Aggrecanase structure
CA002619521A CA2619521A1 (en) 2005-08-25 2006-08-24 Aggrecanase structure
BRPI0616729-2A BRPI0616729A2 (en) 2005-08-25 2006-08-24 agrecanase structure
AU2006282798A AU2006282798A1 (en) 2005-08-25 2006-08-24 Aggrecanase structure
MX2008002323A MX2008002323A (en) 2005-08-25 2006-08-24 Aggrecanase structure.
EP06824853A EP1917354A2 (en) 2005-08-25 2006-08-24 Aggrecanase structure

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US71145705P 2005-08-25 2005-08-25
US71145805P 2005-08-25 2005-08-25
US60/711,458 2005-08-25
US60/711,457 2005-08-25

Publications (3)

Publication Number Publication Date
WO2007025248A2 WO2007025248A2 (en) 2007-03-01
WO2007025248A3 true WO2007025248A3 (en) 2007-08-09
WO2007025248B1 WO2007025248B1 (en) 2007-10-11

Family

ID=37695961

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/033498 WO2007025248A2 (en) 2005-08-25 2006-08-24 Aggrecanase structure

Country Status (7)

Country Link
EP (1) EP1917354A2 (en)
JP (1) JP2009508474A (en)
AU (1) AU2006282798A1 (en)
BR (1) BRPI0616729A2 (en)
CA (1) CA2619521A1 (en)
MX (1) MX2008002323A (en)
WO (1) WO2007025248A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020160492A1 (en) * 2000-07-25 2002-10-31 Cook Michael N. Bovine aggrecanase-1
WO2004011637A2 (en) * 2002-07-29 2004-02-05 Wyeth Modified adamts4 molecules and method of use thereof
US20050277175A1 (en) * 2004-04-16 2005-12-15 Wyeth Truncated ADAMTS molecules

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020160492A1 (en) * 2000-07-25 2002-10-31 Cook Michael N. Bovine aggrecanase-1
WO2004011637A2 (en) * 2002-07-29 2004-02-05 Wyeth Modified adamts4 molecules and method of use thereof
US20050277175A1 (en) * 2004-04-16 2005-12-15 Wyeth Truncated ADAMTS molecules

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ABBASZADE I ET AL: "Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, vol. 274, no. 33, 13 August 1999 (1999-08-13), pages 23443 - 23450, XP002238291, ISSN: 0021-9258 *
LIU R -Q ET AL: "Aggrecanase: The family and its inhibitors", CURRENT MEDICINAL CHEMISTRY - ANTI-INFLAMMATORY & ANTI-ALLERGY AGENTS, vol. 4, no. 3, June 2005 (2005-06-01), pages 251 - 264, XP009078718, ISSN: 1568-0142 *
PORTER S ET AL: "THE ADAMTS METALLOPROTEINASES", BIOCHEMICAL JOURNAL, THE BIOCHEMICAL SOCIETY, LONDON, GB, vol. 386, no. 1, 15 February 2005 (2005-02-15), pages 15 - 27, XP009058542, ISSN: 0264-6021 *
TORTORELLA M D ET AL: "PURIFICATION AND CLONING OF AGGRECANASE-1: MEMBER OF THE ADAMTS FAMILY OF PROTEINS", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 284, June 1999 (1999-06-01), pages 1664 - 1666, XP002937898, ISSN: 0036-8075 *
YASUMOTO T ET AL: "The G1 domain of aggrecan released from porcine articular cartilage forms stable complexes with hyaluronan/link protein", RHEUMATOLOGY 01 FEB 2003 UNITED KINGDOM, vol. 42, no. 2, 1 February 2003 (2003-02-01), pages 336 - 342, XP002419644, ISSN: 1462-0324 *

Also Published As

Publication number Publication date
MX2008002323A (en) 2008-03-18
CA2619521A1 (en) 2007-03-01
BRPI0616729A2 (en) 2009-11-03
AU2006282798A1 (en) 2007-03-01
WO2007025248A2 (en) 2007-03-01
WO2007025248B1 (en) 2007-10-11
JP2009508474A (en) 2009-03-05
EP1917354A2 (en) 2008-05-07

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