WO2007024741A3 - Methods for treatment of thiol-containing compound deficient conditions - Google Patents

Methods for treatment of thiol-containing compound deficient conditions Download PDF

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Publication number
WO2007024741A3
WO2007024741A3 PCT/US2006/032455 US2006032455W WO2007024741A3 WO 2007024741 A3 WO2007024741 A3 WO 2007024741A3 US 2006032455 W US2006032455 W US 2006032455W WO 2007024741 A3 WO2007024741 A3 WO 2007024741A3
Authority
WO
WIPO (PCT)
Prior art keywords
thiol
containing compound
methods
treatment
agents
Prior art date
Application number
PCT/US2006/032455
Other languages
French (fr)
Other versions
WO2007024741A2 (en
Inventor
Brian J Day
Richard T Sawyer
Lee S Newman
Original Assignee
Nat Jewish Med & Res Center
Brian J Day
Richard T Sawyer
Lee S Newman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nat Jewish Med & Res Center, Brian J Day, Richard T Sawyer, Lee S Newman filed Critical Nat Jewish Med & Res Center
Priority to EP06801920.7A priority Critical patent/EP1931345B1/en
Publication of WO2007024741A2 publication Critical patent/WO2007024741A2/en
Publication of WO2007024741A3 publication Critical patent/WO2007024741A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Methods for therapy of cystic fibrosis and other conditions are provided. The methods comprise one or more agents capable of increasing thiol-containing compound transport via a transporter system (i.e. ABC transporters such as MDR-1 or MRP-2) in cells. Other embodiments include the use of agents to modulate transport of thiol-containing compounds within the cell. Therapeutic methods involve the administration of such agents to a patient afflicted with cystic fibrosis and/or another condition responsive to stimulation of thiol-containing compound transport.
PCT/US2006/032455 2005-08-24 2006-08-24 Methods for treatment of thiol-containing compound deficient conditions WO2007024741A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06801920.7A EP1931345B1 (en) 2005-08-24 2006-08-24 Sulfasalazine for treating sarcoidosis, thiol-containing compound deficient condition

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40098005A 2005-08-24 2005-08-24
US10/400,980 2005-08-24

Publications (2)

Publication Number Publication Date
WO2007024741A2 WO2007024741A2 (en) 2007-03-01
WO2007024741A3 true WO2007024741A3 (en) 2007-09-27

Family

ID=37772240

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/032455 WO2007024741A2 (en) 2005-08-24 2006-08-24 Methods for treatment of thiol-containing compound deficient conditions

Country Status (1)

Country Link
WO (1) WO2007024741A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2022014605A (en) 2020-05-19 2022-12-16 Cybin Irl Ltd Deuterated tryptamine derivatives and methods of use.

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040087527A1 (en) * 2002-10-31 2004-05-06 Day Brian J. Methods for treatment of thiol-containing compound deficient conditions

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040087527A1 (en) * 2002-10-31 2004-05-06 Day Brian J. Methods for treatment of thiol-containing compound deficient conditions

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
COMHAIR ET AL.: "Increased Glutathione and Glutathione Peroxidase in Lungs of Individuals with Chronic Beryllium Disease", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 159, no. 6, June 1999 (1999-06-01), pages 1824 - 1829, XP008125417 *
COSTABEL: "CD4/CD8 ratios in bronchoalveolar lavage fluid: of value for diagnosing sarcoidosis?", THE EUROPEAN RESPIRATORY JOURNAL, vol. 10, no. 12, December 1997 (1997-12-01), pages 2699 - 2700, XP008125416 *
See also references of EP1931345A4 *
WANG ET AL.: "Differential Susceptibility to Chronic Beryllium Disease Contributed by Different Glu69 HLA-DPB1 and -DPA1 Alleles", THE JOURNAL OF IMMUNOLOGY, vol. 163, August 1999 (1999-08-01), pages 1647 - 1653, XP008125415 *

Also Published As

Publication number Publication date
WO2007024741A2 (en) 2007-03-01

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