WO2007023148A3 - Nucleic acid variants in the lbp gene associated with altered innate immunity - Google Patents

Nucleic acid variants in the lbp gene associated with altered innate immunity Download PDF

Info

Publication number
WO2007023148A3
WO2007023148A3 PCT/EP2006/065510 EP2006065510W WO2007023148A3 WO 2007023148 A3 WO2007023148 A3 WO 2007023148A3 EP 2006065510 W EP2006065510 W EP 2006065510W WO 2007023148 A3 WO2007023148 A3 WO 2007023148A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
innate immunity
gene associated
acid variants
altered innate
Prior art date
Application number
PCT/EP2006/065510
Other languages
French (fr)
Other versions
WO2007023148A2 (en
Inventor
Lieve Nuytinck
Original Assignee
Innogenetics Nv
Lieve Nuytinck
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innogenetics Nv, Lieve Nuytinck filed Critical Innogenetics Nv
Publication of WO2007023148A2 publication Critical patent/WO2007023148A2/en
Publication of WO2007023148A3 publication Critical patent/WO2007023148A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to a method and kit for identifying a subject at risk of, or having, an indication associated with altered innate immunity. The present invention is based on the determination of LBP genotypes and/or serum levels.
PCT/EP2006/065510 2005-08-22 2006-08-21 Nucleic acid variants in the lbp gene associated with altered innate immunity WO2007023148A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP05107686 2005-08-22
EP05107686.7 2005-08-22
US71438105P 2005-09-06 2005-09-06
US60/714,381 2005-09-06

Publications (2)

Publication Number Publication Date
WO2007023148A2 WO2007023148A2 (en) 2007-03-01
WO2007023148A3 true WO2007023148A3 (en) 2007-06-07

Family

ID=37564074

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/065510 WO2007023148A2 (en) 2005-08-22 2006-08-21 Nucleic acid variants in the lbp gene associated with altered innate immunity

Country Status (1)

Country Link
WO (1) WO2007023148A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101130573B (en) * 2007-09-05 2010-06-02 中国农业科学院北京畜牧兽医研究所 Immune trait associated protein of pig, encoding gene and application of the same
US20110020803A1 (en) * 2007-09-28 2011-01-27 Lieve Nuytinck Markers for the prognosis of lung function and colonization with an infectious agent
GB0803004D0 (en) * 2008-02-19 2008-03-26 Queen Mary & Westfield College Genetic variation associated with coeliac disease
CN103091311B (en) * 2013-01-11 2016-03-30 哈尔滨工业大学（威海） A kind ofly can detect the kit of Prorocentrum donghaiense natural water samples by high flux
EP3668534A1 (en) * 2017-08-16 2020-06-24 Stellenbosch University Lipopolysaccharide-binding protein for use in a method of treating alzheimer's disease
RU2698910C1 (en) * 2019-01-10 2019-09-02 федеральное государственное бюджетное образовательное учреждение высшего образования "Ростовский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО РостГМУ Минздрава России) Method for predisposition determination to development of exudative otitis media

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6268142B1 (en) * 1997-05-29 2001-07-31 Interleukin Genetics, Inc. Diagnostics and therapeutics for diseases associated with an IL-1 inflammatory haplotype
WO2005056837A2 (en) * 2003-11-26 2005-06-23 Applera Corporation Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6268142B1 (en) * 1997-05-29 2001-07-31 Interleukin Genetics, Inc. Diagnostics and therapeutics for diseases associated with an IL-1 inflammatory haplotype
WO2005056837A2 (en) * 2003-11-26 2005-06-23 Applera Corporation Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ATKINSON T PRESCOTT ET AL: "Recurrent otitis media associated with a mutation in the formyl peptide chemotactic receptor on phagocytes", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 107, no. 2, February 2001 (2001-02-01), & 57TH ANNUAL MEETING OF THE AMERICAN ACADEMY OF ALLERGY, ASTHMA AND IMMUNOLOGY; NEW ORLEANS, LOUISIANA, USA; MARCH 16-21, 2001, pages S305, XP002365368, ISSN: 0091-6749 *
CHANOCK S J ET AL: "SNPing away at innate immunity.", THE JOURNAL OF CLINICAL INVESTIGATION. AUG 1999, vol. 104, no. 4, August 1999 (1999-08-01), pages 369 - 370, XP002343688, ISSN: 0021-9738 *
CHOI E H ET AL: "Genetic polymorphisms in molecules of innate immunity and susceptibility to infection with Wuchereria bancrofti in South India.", GENES AND IMMUNITY. AUG 2001, vol. 2, no. 5, August 2001 (2001-08-01), pages 248 - 253, XP008052161, ISSN: 1466-4879 *
DORMAN T ET AL: "Do gene variants really explain the heterogeneous outcomes in sepsis?", CRITICAL CARE MEDICINE. MAR 2001, vol. 29, no. 3, March 2001 (2001-03-01), pages 684 - 685, XP008059206, ISSN: 0090-3493 *
FOSTER C B ET AL: "Mining variations in genes of innate and phagocytic immunity: current status and future prospects.", CURRENT OPINION IN HEMATOLOGY. JAN 2000, vol. 7, no. 1, January 2000 (2000-01-01), pages 9 - 15, XP008052162, ISSN: 1065-6251 *
HUBACEK JAROSLAV A ET AL: "The genomic organization of the genes for human lipopolysaccharide binding protein (LBP) and bactericidal permeability increasing protein (BPI) is highly conserved", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 236, no. 2, 1997, pages 427 - 430, XP002176241, ISSN: 0006-291X *
KIRSCHNING C J ET AL: "Similar Organization of the Lipopolysaccharide-Binding Protein (LBP) and Phospholipid Transfer Protein (PLTP) Genes Suggests a Common Gene Family of Lipid-Binding Proteins", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 46, no. 3, 15 December 1997 (1997-12-15), pages 416 - 425, XP004459035, ISSN: 0888-7543 *

Also Published As

Publication number Publication date
WO2007023148A2 (en) 2007-03-01

Similar Documents

Publication Publication Date Title
WO2007025989A3 (en) Nucleic acid variants in the toll like receptor genes associated with altered innate immunity
WO2007023148A3 (en) Nucleic acid variants in the lbp gene associated with altered innate immunity
WO2005115481A3 (en) Nuclease resistant double-stranded ribonucleic acid
WO2006043178A3 (en) Enzymes
WO2009143624A8 (en) Methods of diagnosing rejection of a kidney allograft using genomic or proteomic expression profiling
WO2005087951A3 (en) Reagents, methods and kits for use in deactivating nucleic acids
WO2006089091A3 (en) Methods for detecting minimum residual disease
WO2004112589A3 (en) Method for the detection of gene transcripts in blood and uses thereof
TW200745556A (en) Biomarkers for liver fibrotic injury
WO2007086980A3 (en) Methods of determining the risk of developing coronary artery disease
WO2009037266A3 (en) Method for detecting or quantifying a truncating mutation
WO2015081110A3 (en) Method for predicting congenital heart defect
WO2009062166A3 (en) Dna microarray based identification and mapping of balanced translocation breakpoints
WO2008034622A3 (en) A method of detecting and/or quantifying expression of a target protein candidate in a cell, and a method of identifying a target protein of a small molecule modulator
WO2010051214A8 (en) Compositions and methods for detecting mutations in jak2 nucleic acid
WO2006012356A3 (en) Methods for determining risk of developing regular smoking behavior
WO2008117813A1 (en) Chicken embryonic stem cell and method for evaluation thereof
WO2014101276A3 (en) Method, kit and primers for determining whether two predetermined sites in nucleic acid sample have known mutations
WO2007060647A3 (en) A method for detecting or monitoring sepsis by analysing cytokine mrna expression levels
EP1818394A3 (en) Mutant Endonuclease V
WO2008072217A3 (en) Nucleic acids probes for detection of yeast and fungal species
WO2006097388A3 (en) Nucleic acid variants in the c1qr1 gene associated with altered innate immunity.
WO2007100637A3 (en) Methods for mutation detection
WO2007140004A3 (en) Primers for use in detecting metallo-beta-lactamases
WO2005070014A3 (en) Enzymatic methionine assay

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 06778298

Country of ref document: EP

Kind code of ref document: A2