WO2007022508A3 - Technologie hyperspectrale permettant d'evaluer et de traiter la maladie des tissus et du pied diabetiques - Google Patents
Technologie hyperspectrale permettant d'evaluer et de traiter la maladie des tissus et du pied diabetiques Download PDFInfo
- Publication number
- WO2007022508A3 WO2007022508A3 PCT/US2006/032593 US2006032593W WO2007022508A3 WO 2007022508 A3 WO2007022508 A3 WO 2007022508A3 US 2006032593 W US2006032593 W US 2006032593W WO 2007022508 A3 WO2007022508 A3 WO 2007022508A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- assessing
- diabetic foot
- treatment
- tissue
- tissue disease
- Prior art date
Links
- 208000008960 Diabetic foot Diseases 0.000 title abstract 2
- 208000026062 Tissue disease Diseases 0.000 title 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 230000010412 perfusion Effects 0.000 abstract 2
- 208000025865 Ulcer Diseases 0.000 abstract 1
- 238000002266 amputation Methods 0.000 abstract 1
- 210000000746 body region Anatomy 0.000 abstract 1
- 238000000701 chemical imaging Methods 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 238000009556 duplex ultrasonography Methods 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000001931 thermography Methods 0.000 abstract 1
- 230000036269 ulceration Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/2823—Imaging spectrometer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
- A61B5/412—Detecting or monitoring sepsis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
- A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
- A61B5/445—Evaluating skin irritation or skin trauma, e.g. rash, eczema, wound, bed sore
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4884—Other medical applications inducing physiological or psychological stress, e.g. applications for stress testing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7271—Specific aspects of physiological measurement analysis
- A61B5/7275—Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H30/00—ICT specially adapted for the handling or processing of medical images
- G16H30/20—ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
- A61B5/0261—Measuring blood flow using optical means, e.g. infrared light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
- A61B5/1036—Measuring load distribution, e.g. podologic studies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
- A61B5/1036—Measuring load distribution, e.g. podologic studies
- A61B5/1038—Measuring plantar pressure during gait
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
- A61B5/107—Measuring physical dimensions, e.g. size of the entire body or parts thereof
- A61B5/1074—Foot measuring devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
- A61B6/507—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for determination of haemodynamic parameters, e.g. perfusion CT
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N2021/4704—Angular selective
- G01N2021/4709—Backscatter
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H30/00—ICT specially adapted for the handling or processing of medical images
- G16H30/40—ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Public Health (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Surgery (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Primary Health Care (AREA)
- General Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Physiology (AREA)
- Data Mining & Analysis (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Databases & Information Systems (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Child & Adolescent Psychology (AREA)
- Signal Processing (AREA)
- Radiology & Medical Imaging (AREA)
- Artificial Intelligence (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Optics & Photonics (AREA)
- Vascular Medicine (AREA)
- Developmental Disabilities (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Social Psychology (AREA)
- Dermatology (AREA)
Abstract
Cette invention concerne d'une manière générale une carte-index comprenant des informations à la fois de pression et de perfusion relatives au pied d'un patient diabétique à des fins de traitement. La carte-index peut également être une carte de perfusion et/ou métabolisme des tissus (reflétant l'apport d'oxygène et l'extraction d'oxygène) obtenue par imagerie thermique, imagerie hyperspectrale ou par balayage par ultrasons duplex, angiographie par résonance magnétique (ARM), tomographie par ordinateur (CT) ou imagerie Doppler à laser. Ces informations contribuent au traitement en prévention de l'ulcération et de l'amputation du pied diabétique et au traitement de tissus touchés en prévention de la perte de tissus dans d'autre régions du corps.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2656016A CA2656016C (fr) | 2005-08-19 | 2006-08-21 | Technologie hyperspectrale permettant d'evaluer et de traiter la maladie des tissus et du pied diabetiques |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70942205P | 2005-08-19 | 2005-08-19 | |
US60/709,422 | 2005-08-19 | ||
US78597706P | 2006-03-27 | 2006-03-27 | |
US60/785,977 | 2006-03-27 | ||
US11/396,941 | 2006-04-04 | ||
US11/396,941 US8374682B2 (en) | 2005-04-04 | 2006-04-04 | Hyperspectral imaging in diabetes and peripheral vascular disease |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007022508A2 WO2007022508A2 (fr) | 2007-02-22 |
WO2007022508A3 true WO2007022508A3 (fr) | 2007-10-11 |
Family
ID=37758491
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/032593 WO2007022508A2 (fr) | 2005-08-19 | 2006-08-21 | Technologie hyperspectrale permettant d'evaluer et de traiter la maladie des tissus et du pied diabetiques |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2007022508A2 (fr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8988680B2 (en) | 2010-04-30 | 2015-03-24 | Chemimage Technologies Llc | Dual polarization with liquid crystal tunable filters |
US9766382B2 (en) * | 2012-06-05 | 2017-09-19 | Hypermed Imaging, Inc. | Single-sensor hyperspectral imaging device |
EP3504590A4 (fr) | 2016-08-24 | 2020-07-29 | Mimosa Diagnostics Inc. | Évaluation multispectrale de tissu mobile |
JP2017000836A (ja) * | 2016-09-27 | 2017-01-05 | Hoya株式会社 | 電子内視鏡装置 |
CN107389601B (zh) * | 2017-08-25 | 2020-02-14 | 天津商业大学 | 基于高光谱的芒果冲击损伤后可滴定酸含量预测方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5088503A (en) * | 1987-05-21 | 1992-02-18 | Peter Seitz | Method and apparatus for the production of inserts |
US6122846A (en) * | 1999-08-30 | 2000-09-26 | Frank B. Gray | Force monitoring shoe |
US20030139667A1 (en) * | 2000-04-13 | 2003-07-24 | Hewko Mark D. | Tissue viability/health monitor utilizing near infrared spectroscopy |
-
2006
- 2006-08-21 WO PCT/US2006/032593 patent/WO2007022508A2/fr active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5088503A (en) * | 1987-05-21 | 1992-02-18 | Peter Seitz | Method and apparatus for the production of inserts |
US6122846A (en) * | 1999-08-30 | 2000-09-26 | Frank B. Gray | Force monitoring shoe |
US20030139667A1 (en) * | 2000-04-13 | 2003-07-24 | Hewko Mark D. | Tissue viability/health monitor utilizing near infrared spectroscopy |
Also Published As
Publication number | Publication date |
---|---|
WO2007022508A2 (fr) | 2007-02-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2007022508A3 (fr) | Technologie hyperspectrale permettant d'evaluer et de traiter la maladie des tissus et du pied diabetiques | |
WO2007115174A3 (fr) | Système, procédés, et instrumentation pour le traitement de la prostate guidé par l'image | |
WO2006009786A3 (fr) | Dispositif d'imagerie intravasculaire et ses utilisations | |
WO2008034068A3 (fr) | Pompe à sang intravasculaire et cathéter | |
TW200806255A (en) | Improved calibration method for catheter tracking system using medical imaging data | |
Larger et al. | Insulin therapy does not itself induce weight gain in patients with type 2 diabetes. | |
Damkjær et al. | The giraffe kidney tolerates high arterial blood pressure by high renal interstitial pressure and low glomerular filtration rate | |
Diaz Dilernia et al. | Gluteal compartment syndrome secondary to pelvic trauma | |
Patrizi et al. | Familial anetoderma: a report of two families | |
Radhakrishnan et al. | KI reports and world kidney day | |
WO2007022484A3 (fr) | Hemostase a induction acoustique et spectroscopie optique in vivo | |
Gotzsche | Commentary: Medicalisation of risk factors. | |
WO2010021606A8 (fr) | Masque de protection jetable pour médecins | |
Ramakrishnan et al. | Laparoscopic division of median arcuate ligament for the celiac axis compression syndrome—two case reports with review of literature | |
WO2007015094A3 (fr) | Composes et procedes d'imagerie | |
Philippon | Hydrocéphalie «à pression normale» | |
Yoshida et al. | Dermoscopic features of ulcerated gouty tophus | |
Blair | Slice of Life. | |
Antunes-Duarte et al. | sQuiz your knowledge! A waxy nodule on the toe | |
Makino et al. | Detection of human papillomavirus type 35 in recurrent Bowen's disease lesions of the fingers | |
Rep | Kidney Day | |
Pressac | Tamm-Horsfall protein | |
Al-Hilali | Prevalence of Hypertension in Type Two Diabetes Mellitus & it's State of Control | |
Wan | Methylprednisolone/tacrolimus | |
Bhagawan et al. | Cysticercosis of Oral Cavity: Report of a Rare Case |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
NENP | Non-entry into the national phase |
Ref country code: DE |
|
32PN | Ep: public notification in the ep bulletin as address of the adressee cannot be established |
Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 112(1) EPC, EPO FORM 1205A DATED 03/06/2008 |
|
ENP | Entry into the national phase |
Ref document number: 2656016 Country of ref document: CA |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 06813605 Country of ref document: EP Kind code of ref document: A2 |