WO2007022026A3 - Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof - Google Patents

Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof Download PDF

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Publication number
WO2007022026A3
WO2007022026A3 PCT/US2006/031534 US2006031534W WO2007022026A3 WO 2007022026 A3 WO2007022026 A3 WO 2007022026A3 US 2006031534 W US2006031534 W US 2006031534W WO 2007022026 A3 WO2007022026 A3 WO 2007022026A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
manipulation
assay
synthesis
manufacture
Prior art date
Application number
PCT/US2006/031534
Other languages
French (fr)
Other versions
WO2007022026A2 (en
Inventor
Robert Hess
John Linton
Tanya S Kanigan
Colin Brenan
Can Ozbal
Daniel Horowitz
Sergey E Ilyin
Original Assignee
Biotrove Inc
Robert Hess
John Linton
Tanya S Kanigan
Colin Brenan
Can Ozbal
Daniel Horowitz
Sergey E Ilyin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotrove Inc, Robert Hess, John Linton, Tanya S Kanigan, Colin Brenan, Can Ozbal, Daniel Horowitz, Sergey E Ilyin filed Critical Biotrove Inc
Priority to EP06801354A priority Critical patent/EP1920045A4/en
Priority to AU2006279763A priority patent/AU2006279763A1/en
Priority to CA002619250A priority patent/CA2619250A1/en
Priority to JP2008526264A priority patent/JP2009504161A/en
Publication of WO2007022026A2 publication Critical patent/WO2007022026A2/en
Publication of WO2007022026A3 publication Critical patent/WO2007022026A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B01L3/50255—Multi-well filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50857—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates using arrays or bundles of open capillaries for holding samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065—Multiple transfer devices
    • G01N35/1074—Multiple transfer devices arranged in a two-dimensional array
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0409—Sample holders or containers
    • H01J49/0418—Sample holders or containers for laser desorption, e.g. matrix-assisted laser desorption/ionisation [MALDI] plates or surface enhanced laser desorption/ionisation [SELDI] plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0819—Microarrays; Biochips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/10—Means to control humidity and/or other gases
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0442—Moving fluids with specific forces or mechanical means specific forces thermal energy, e.g. vaporisation, bubble jet
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0289—Apparatus for withdrawing or distributing predetermined quantities of fluid
    • B01L3/0293—Apparatus for withdrawing or distributing predetermined quantities of fluid for liquids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/466—Flow patterns using more than one column with separation columns in parallel
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6091—Cartridges

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • Biochemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention features methods of making devices, or 'platens', having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. Further, methods of making high density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays are provided. The invention includes methods by which many physical, chemical or biological transformations can be implemented in seπal or in parallel within each addressable through-hole of the devices. Additionally, methods of analyzing the contents of the array, including assaying of physical properties of the samples are included.
PCT/US2006/031534 2005-08-11 2006-08-10 Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof WO2007022026A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP06801354A EP1920045A4 (en) 2005-08-11 2006-08-10 Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof
AU2006279763A AU2006279763A1 (en) 2005-08-11 2006-08-10 Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof
CA002619250A CA2619250A1 (en) 2005-08-11 2006-08-11 Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof
JP2008526264A JP2009504161A (en) 2005-08-11 2006-08-11 Apparatus for assay, synthesis and storage, and methods for making, using and operating the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70750105P 2005-08-11 2005-08-11
US60/707,501 2005-08-11

Publications (2)

Publication Number Publication Date
WO2007022026A2 WO2007022026A2 (en) 2007-02-22
WO2007022026A3 true WO2007022026A3 (en) 2008-01-24

Family

ID=37758246

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/031534 WO2007022026A2 (en) 2005-08-11 2006-08-10 Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof

Country Status (5)

Country Link
EP (1) EP1920045A4 (en)
JP (1) JP2009504161A (en)
AU (1) AU2006279763A1 (en)
CA (1) CA2619250A1 (en)
WO (1) WO2007022026A2 (en)

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Also Published As

Publication number Publication date
EP1920045A2 (en) 2008-05-14
JP2009504161A (en) 2009-02-05
AU2006279763A1 (en) 2007-02-22
CA2619250A1 (en) 2007-02-22
WO2007022026A2 (en) 2007-02-22
EP1920045A4 (en) 2011-07-06

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