WO2007021822A3 - Compositions and methods of preparation of liposomal microparticulate il-12 - Google Patents

Compositions and methods of preparation of liposomal microparticulate il-12 Download PDF

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Publication number
WO2007021822A3
WO2007021822A3 PCT/US2006/031173 US2006031173W WO2007021822A3 WO 2007021822 A3 WO2007021822 A3 WO 2007021822A3 US 2006031173 W US2006031173 W US 2006031173W WO 2007021822 A3 WO2007021822 A3 WO 2007021822A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
microparticulate
liposomal
preparation
methods
Prior art date
Application number
PCT/US2006/031173
Other languages
French (fr)
Other versions
WO2007021822A2 (en
Inventor
Sathy V Balu-Iyer
Richard B Bankert
Vivek S Purohit
Original Assignee
Res Foundation Of State Of Uni
Sathy V Balu-Iyer
Richard B Bankert
Vivek S Purohit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Res Foundation Of State Of Uni, Sathy V Balu-Iyer, Richard B Bankert, Vivek S Purohit filed Critical Res Foundation Of State Of Uni
Publication of WO2007021822A2 publication Critical patent/WO2007021822A2/en
Publication of WO2007021822A3 publication Critical patent/WO2007021822A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/208—IL-12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

This invention provides methods and compositions for localized delivery of IL- 12 to a desired site. The composition comprises liposomes carrying IL-12. The liposomes comprise phosphatidyl choline, phosphatidyl glycerol and cholesterol. The size and composition of the liposomes is such that there is minimal leakage into the systemic circulation. These compositions can be used for delivery of IL- 12 to selected sites such as tumors.
PCT/US2006/031173 2005-08-09 2006-08-09 Compositions and methods of preparation of liposomal microparticulate il-12 WO2007021822A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70665005P 2005-08-09 2005-08-09
US60/706,650 2005-08-09

Publications (2)

Publication Number Publication Date
WO2007021822A2 WO2007021822A2 (en) 2007-02-22
WO2007021822A3 true WO2007021822A3 (en) 2008-11-27

Family

ID=37758153

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/031173 WO2007021822A2 (en) 2005-08-09 2006-08-09 Compositions and methods of preparation of liposomal microparticulate il-12

Country Status (2)

Country Link
US (1) US7662405B2 (en)
WO (1) WO2007021822A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9693968B2 (en) 2013-03-14 2017-07-04 Jerome J. Schentag Cholestosome vesicles for incorporation of molecules into chylomicrons
CN107530291A (en) * 2015-03-03 2018-01-02 奎尔波特股份有限公司 Double heavy duty liposomal pharmaceutical preparations
CN107530283A (en) 2015-03-03 2018-01-02 奎尔波特股份有限公司 Combine liposomal pharmaceutical preparation

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5908620A (en) * 1995-01-31 1999-06-01 National Jewish Medical And Research Center Treatment for diseases involving inflammation
US20010043914A1 (en) * 1999-12-28 2001-11-22 Edith Mathiowitz Methods and products for tumor immunotherapy
US6423308B1 (en) * 1998-09-15 2002-07-23 Wyeth Treatment of Kaposi's sarcoma with IL-12
US6544549B1 (en) * 1997-10-01 2003-04-08 Biomira Usa Inc. Multilamellar coalescence vesicles (MLCV) containing biologically active compounds
US6787132B1 (en) * 1997-12-04 2004-09-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Combined chemo-immunotherapy with liposomal drugs and cytokines

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4127502A (en) * 1977-06-10 1978-11-28 Eastman Kodak Company Stabilizers for reconstituted, lyophilized samples
US4795806A (en) * 1987-07-16 1989-01-03 Miles Laboratories, Inc. Phospholipid affinity purification of Factor VIII:C
US5580856A (en) * 1994-07-15 1996-12-03 Prestrelski; Steven J. Formulation of a reconstituted protein, and method and kit for the production thereof
EP0981548A4 (en) * 1997-04-30 2005-11-23 Enzon Inc Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof
US6033708A (en) * 1997-09-30 2000-03-07 The United States Of America As Represented By The Secretary Of The Navy Method for producing sterile filterable liposome dispersion
AU747391B2 (en) * 1998-04-27 2002-05-16 Cantab Biopharmaceuticals Patents Limited Pharmaceutical composition comprising factor VIII and neutral liposomes
AU2002239607A1 (en) * 2000-11-30 2002-06-11 Baxter Healthcare Corporation Ahf associated dispersion system and method for preparation
ZA200305980B (en) * 2001-02-12 2007-01-31 Res Dev Foundation Modified proteins, designer toxins, and methods of making thereof
WO2003013245A1 (en) 2001-08-07 2003-02-20 Wisconsin Alumni Research Foundation Polyamines and analogs for protecting cells during cancer chemotherapy and radiotherapy
US20040247661A1 (en) * 2002-07-03 2004-12-09 Dov Michaeli Liposomal vaccine
WO2004071420A2 (en) * 2003-02-05 2004-08-26 The Research Foundation Of State University Of New York Compositions and methods for less immunogenic protein formulations
EP1624857A2 (en) * 2003-05-12 2006-02-15 Novosom AG Injectable depots consisting of liposomal aggregates for the delivery of active substances
US7939058B2 (en) * 2003-07-03 2011-05-10 University Of Southern California Uses of IL-12 in hematopoiesis

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5908620A (en) * 1995-01-31 1999-06-01 National Jewish Medical And Research Center Treatment for diseases involving inflammation
US6544549B1 (en) * 1997-10-01 2003-04-08 Biomira Usa Inc. Multilamellar coalescence vesicles (MLCV) containing biologically active compounds
US6787132B1 (en) * 1997-12-04 2004-09-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Combined chemo-immunotherapy with liposomal drugs and cytokines
US6423308B1 (en) * 1998-09-15 2002-07-23 Wyeth Treatment of Kaposi's sarcoma with IL-12
US20010043914A1 (en) * 1999-12-28 2001-11-22 Edith Mathiowitz Methods and products for tumor immunotherapy

Also Published As

Publication number Publication date
US20070071804A1 (en) 2007-03-29
US7662405B2 (en) 2010-02-16
WO2007021822A2 (en) 2007-02-22

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