WO2007020633A3 - Avirulent trophozoites of entamoeba histolytica for vaccination against amoebiasis - Google Patents

Avirulent trophozoites of entamoeba histolytica for vaccination against amoebiasis Download PDF

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Publication number
WO2007020633A3
WO2007020633A3 PCT/IL2006/000942 IL2006000942W WO2007020633A3 WO 2007020633 A3 WO2007020633 A3 WO 2007020633A3 IL 2006000942 W IL2006000942 W IL 2006000942W WO 2007020633 A3 WO2007020633 A3 WO 2007020633A3
Authority
WO
WIPO (PCT)
Prior art keywords
trophozoites
avirulent
entamoeba histolytica
vaccination against
amoebiasis
Prior art date
Application number
PCT/IL2006/000942
Other languages
French (fr)
Other versions
WO2007020633A2 (en
Inventor
Rivka Bracha
Yael Nuchamowitz
Michael Anbar
David Mirelman
Original Assignee
Yeda Research And Development Co. Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Research And Development Co. Ltd. filed Critical Yeda Research And Development Co. Ltd.
Publication of WO2007020633A2 publication Critical patent/WO2007020633A2/en
Publication of WO2007020633A3 publication Critical patent/WO2007020633A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/10—Protozoa; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/10—Protozoa; Culture media therefor
    • C12N1/105—Protozoal isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/90—Protozoa ; Processes using protozoa
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to a novel pharmaceutical composition and methods of production thereof for the prevention of amoebiasis and, more particularly, to a live vaccine in which more than one Entamoeba histolytica virulence factor gene has been silenced.
PCT/IL2006/000942 2005-08-15 2006-08-14 Avirulent trophozoites of entamoeba histolytica for vaccination against amoebiasis WO2007020633A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US70795805P 2005-08-15 2005-08-15
US60/707,958 2005-08-15
US80810806P 2006-05-25 2006-05-25
US60/808,108 2006-05-25

Publications (2)

Publication Number Publication Date
WO2007020633A2 WO2007020633A2 (en) 2007-02-22
WO2007020633A3 true WO2007020633A3 (en) 2011-05-19

Family

ID=37757959

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2006/000942 WO2007020633A2 (en) 2005-08-15 2006-08-14 Avirulent trophozoites of entamoeba histolytica for vaccination against amoebiasis

Country Status (1)

Country Link
WO (1) WO2007020633A2 (en)

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BUJANOVER, S. ET AL.: "A virulence attenuated amoebapore-less mutant of entamoeba histolytica and its interaction with host cells.", INTER. J. PARASITOL, vol. 33, 2003, pages 1655 - 1663 *
MOODY, S. ET AL.: "Identification of significant variation in the composition of lipophosphoglycan-like molecules of E. histolytica and E. dispar.", J. EUK. MICROBIOL., vol. 45, no. 2, 1998, pages 9S - 12S *
RIVKA, B. ET AL.: "Transcriptional silencing of multiple genes in trophozoites of Entamoeba histolytica.", PLOS PANTHOGENS, vol. 2, no. 5, 26 May 2006 (2006-05-26), pages 431 - 441 *

Also Published As

Publication number Publication date
WO2007020633A2 (en) 2007-02-22

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