WO2007020631A3 - Tetracyclic benzofuran derivatives with therapeutic activities - Google Patents

Tetracyclic benzofuran derivatives with therapeutic activities Download PDF

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Publication number
WO2007020631A3
WO2007020631A3 PCT/IL2006/000940 IL2006000940W WO2007020631A3 WO 2007020631 A3 WO2007020631 A3 WO 2007020631A3 IL 2006000940 W IL2006000940 W IL 2006000940W WO 2007020631 A3 WO2007020631 A3 WO 2007020631A3
Authority
WO
WIPO (PCT)
Prior art keywords
tetracyclic
benzofuran derivatives
therapeutic activities
derivatives
compounds
Prior art date
Application number
PCT/IL2006/000940
Other languages
French (fr)
Other versions
WO2007020631A2 (en
Inventor
Avihai Yacovan
Aaron Garzon
Flavio Grynszpan
Avi Bar-Joseph
Sigal Meilin
Original Assignee
Pharmos Corp
Avihai Yacovan
Aaron Garzon
Flavio Grynszpan
Avi Bar-Joseph
Sigal Meilin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmos Corp, Avihai Yacovan, Aaron Garzon, Flavio Grynszpan, Avi Bar-Joseph, Sigal Meilin filed Critical Pharmos Corp
Publication of WO2007020631A2 publication Critical patent/WO2007020631A2/en
Publication of WO2007020631A3 publication Critical patent/WO2007020631A3/en
Priority to IL189404A priority Critical patent/IL189404A0/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to tetracyclic-berizofuran derivatives of formula I to pharmaceutical compositions comprising same, and to methods of use thereof. Certain compounds of the invention share some pharmacological properties with cannabinoids and have a common wide range of beneficial therapeutic indications. In particular, compounds of the invention are useful as analgesic and anti-inflammatory agents.
PCT/IL2006/000940 2005-08-16 2006-08-14 Tetracyclic benzofuran derivatives with therapeutic activities WO2007020631A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL189404A IL189404A0 (en) 2005-08-16 2008-02-10 Tetracyclic benzofuran derivatives with therapeutic activities

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70836705P 2005-08-16 2005-08-16
US60/708,367 2005-08-16

Publications (2)

Publication Number Publication Date
WO2007020631A2 WO2007020631A2 (en) 2007-02-22
WO2007020631A3 true WO2007020631A3 (en) 2007-05-18

Family

ID=37600800

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2006/000940 WO2007020631A2 (en) 2005-08-16 2006-08-14 Tetracyclic benzofuran derivatives with therapeutic activities

Country Status (1)

Country Link
WO (1) WO2007020631A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9505776B2 (en) 2013-03-14 2016-11-29 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
EP3110793B1 (en) 2014-02-24 2019-08-21 Alkermes Pharma Ireland Limited Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MECHOULAM R ET AL: "Cannabimimetic activity of novel enantiomeric, benzofuran cannabinoids", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 33, no. 3, 1990, pages 1037 - 1043, XP002414722, ISSN: 0022-2623 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9505776B2 (en) 2013-03-14 2016-11-29 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases

Also Published As

Publication number Publication date
WO2007020631A2 (en) 2007-02-22

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