WO2007015999A2 - Process for synthesizing a substituted pyrazole - Google Patents
Process for synthesizing a substituted pyrazole Download PDFInfo
- Publication number
- WO2007015999A2 WO2007015999A2 PCT/US2006/028545 US2006028545W WO2007015999A2 WO 2007015999 A2 WO2007015999 A2 WO 2007015999A2 US 2006028545 W US2006028545 W US 2006028545W WO 2007015999 A2 WO2007015999 A2 WO 2007015999A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- formula
- produce
- ester
- reacting
- Prior art date
Links
- 0 C[C@](c(cc1)ccc1C(O*)=O)NN Chemical compound C[C@](c(cc1)ccc1C(O*)=O)NN 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C241/00—Preparation of compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C241/02—Preparation of hydrazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C241/00—Preparation of compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C241/04—Preparation of hydrazides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/02—Compounds containing any of the groups, e.g. carbazates
Definitions
- the present invention relates to a process for synthesizing a substituted pyrazole.
- the compound is particularly useful as an anti-diabetic compound.
- the compound has demonstrated activity as a glucagon receptor antagonist.
- Glucagon serves as the major regulatory hormone attenuating the effect of insulin in its inhibition of liver gluconeogenesis and is normally secreted by ⁇ -cells in pancreatic islets in response to falling blood glucose levels.
- the hormone binds to specific receptors in liver cells that triggers glycogenolysis and an increase in gluconeogenesis through cAMP-mediated events. These responses generate glucose (e.g. hepatic glucose production) to help maintain euglycemia by preventing blood glucose levels from falling significantly.
- type II diabetics In addition to elevated levels of circulating insulin, type II diabetics have elevated levels of plasma glucagon and increased rates of hepatic glucose production.
- One object of the present invention is to provide a process wherein the protecting groups are easily removed without resort to harsh deprotection conditions.
- Another object of the present invention is to provide a process which facilitates selective deprotection.
- the present invention involves a process of synthesizing a compound of formula I:
- a pharmaceutically acceptable salt or solvate thereof comprising reacting a compound of formula IE: with 1,1 '-carbonyldiimidazole and a beta alanine ester or a salt or solvate thereof, and hydrolyzing with a base to pOrovide a compound of formula I.
- Ph 2 -Fc-P-(IBu) 2 is a Josiphos ligand which is disclosed in U. S. Pat. No. 6,777,567B2 (Solvias) and commercially available from Strem.
- Xyl-P-Phos is disclosed in U.S. Pat No. 5,886,182 (Synetix) and commercially available from Strem.
- Me-f-Ketal phos is similarly commercially available from Chiral Quest.
- Rh based catalysts may be used as well.
- the compound described herein may be prepared according to the methodology outlined in the following general synthetic schemes.
- R 1 represents a suitable ester forming group.
- Examples include C 1-I0 alkyl, such as ethyl, isopropyl, t-butyl, t-butylcyclohexyl and the like, and benzyl. Preferred is ethyl.
- Prot Gp-hydrazine refers to a protected hydrazine, protected with a suitable protecting group, designated Prot Gp, which represents the protecting group.
- suitable protecting group designated Prot Gp, which represents the protecting group. Examples include t-butoxycarbonyl, methoxycarbonyl, carboxybenzoyl, benzyl and the like.
- Ketone A is condensed with a protected hydrazine to produce a protected hydrazone B.
- This condensation reaction is conducted in a suitable solvent, such as toluene, under acidic conditions, with for example, acetic acid, at about 60 degrees C.
- the protected hydrazone B is asymmetrically hydrogenated using a hydrogen source, such as hydrogen gas, and a catalyst to produce a chiral N-protected-hydrazine C.
- This hydrazine is produced in enantiomeric excess (approximately 86%ee).
- a suitable catalyst for this conversion is a precatalyst, such as Rh(COD)BF 4 mixed with a suitable ligand, such as Josiphos.
- Deprotection of the protecting group in C and subsequent enantiomeric excess upgrade using benzene sulfonic acid in ethanol provides a crystalline hydrazine D as the benzenesulfonate salt (not shown), with greater than 99% enantiomeric excess.
- the 1 ,3-dione G is prepared by condensation of ester E and ketone F in the presence of a base, such as potassium t-butoxide. Cyclization between D and G can then be undertaken in a suitable solvent, such as DMAc, NMP and the like, in the presence of an additive.
- suitable solvent such as DMAc, NMP and the like
- additives include LiCl, LiBr, MgBr 2 and other Lewis acids. Alternatively, tetrabutyl ammonium chloride can be used.
- the additive provides high regioselectivity, as high as about 17:1.
- the ester forming moiety of compound // is thereafter hydrolyzed with a suitable base, for example, NaOH, to produce acid ///.
- acid III can then be combined with a beta alanine ester, or a salt or solvate thereof, preferably the HCl salt, to form the beta alanyl ester of ///(not shown).
- This ester may then be hydrolyzed, such as with additional base, for example, NaOH, and optionally crystallized, such as from acetonitrile and water, to produce the title compound /as a free acid.
- 3,5-dichlorophenylacetylene J is produced by displacing bromine from bromo- 3,5-dichlorobenzene H. Such reactions are typically conducted under an inert atmosphere, in base, e.g., triethylamine in a suitable solvent.
- This intermediate is reacted with 6-methoxy-2-naphthoic acid chloride K to produce an acetylenic ketone L.
- the acetylenic ketone L is thereafter reacted with the chiral hydrazine D to produce the chiral intermediate //.
- Compound // is thereafter incorporated into the synthesis described above with respect to Scheme 3, reacting with a beta alanyl ester and then hydrolyzing to produce the target compound /.
- the daily dosage range for the compound of formula I is within the general range of from about 0.001 mg to about 1000 mg, in single or divided doses. It may be necessary to use dosages outside of these limits in some cases. Representative dosages for adults thus range from about 0.1 mg to about 1.0 g per day, preferably about 1 mg to about 200 mg, in single or divided doses.
- compositions comprise a compound of Formula I or a pharmaceutically acceptable salt or solvate thereof and a pharmaceutically acceptable carrier.
- a pharmaceutically acceptable carrier encompasses a product comprising the active compound and one or more inert ingredient(s), (pharmaceutically acceptable excipients) that make up the carrier, as well as any product which results, directly or indirectly, from the combination, complexation or aggregation of any two or more of the ingredients, or from dissociation of one or more of the ingredients, or from other types of reactions or interactions between ingredients.
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06800239A EP1910303A2 (en) | 2005-07-26 | 2006-07-21 | Process for synthesizing a substituted pyrazole |
CA002614537A CA2614537A1 (en) | 2005-07-26 | 2006-07-21 | Process for synthesizing a substituted pyrazole |
JP2008524008A JP2009502923A (en) | 2005-07-26 | 2006-07-21 | Method for the synthesis of substituted pyrazoles |
US11/988,849 US7709658B2 (en) | 2005-07-26 | 2006-07-21 | Process for synthesizing a substituted pyrazole |
AU2006276072A AU2006276072A1 (en) | 2005-07-26 | 2006-07-21 | Process for synthesizing a substituted pyrazole |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70245405P | 2005-07-26 | 2005-07-26 | |
US60/702,454 | 2005-07-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007015999A2 true WO2007015999A2 (en) | 2007-02-08 |
WO2007015999A3 WO2007015999A3 (en) | 2007-06-28 |
Family
ID=37460179
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/028545 WO2007015999A2 (en) | 2005-07-26 | 2006-07-21 | Process for synthesizing a substituted pyrazole |
Country Status (7)
Country | Link |
---|---|
US (1) | US7709658B2 (en) |
EP (1) | EP1910303A2 (en) |
JP (1) | JP2009502923A (en) |
CN (1) | CN101300232A (en) |
AU (1) | AU2006276072A1 (en) |
CA (1) | CA2614537A1 (en) |
WO (1) | WO2007015999A2 (en) |
Cited By (13)
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---|---|---|---|---|
WO2009035558A1 (en) * | 2007-09-12 | 2009-03-19 | Merck & Co., Inc. | Process for the production of a crystalline glucagon receptor antagonist compound |
DE102008057718A1 (en) | 2008-11-17 | 2010-05-20 | Skw Stickstoffwerke Piesteritz Gmbh | Regioselective preparation of N-(1H-pyrazolyl methyl)amide compounds, useful e.g. as nitrification inhibitors, comprises reacting hydrazine methyl carboxylic acid amide compounds with 1,3-dicarbonyl compounds |
WO2010144664A1 (en) * | 2009-06-12 | 2010-12-16 | Schering Corporation | Thiophenes as glucagon receptor antagonists, compositions, and methods for their use |
US8507533B2 (en) | 2011-02-08 | 2013-08-13 | Pfizer Inc. | Glucagon receptor modulators |
US8623818B2 (en) | 2008-05-16 | 2014-01-07 | Merck Sharp & Dohme Corp. | Glucagon receptor antagonists, compositions, and methods for their use |
US8710236B2 (en) | 2007-02-09 | 2014-04-29 | Metabasis Therapeutics, Inc. | Antagonists of the glucagon receptor |
US8809342B2 (en) | 2010-12-23 | 2014-08-19 | Pfizer Inc. | Glucagon receptor modulators |
EP2799428A2 (en) | 2008-08-13 | 2014-11-05 | Metabasis Therapeutics, Inc. | Glucagon antagonists |
US8927577B2 (en) | 2011-07-22 | 2015-01-06 | Pfizer Inc. | Quinolinyl glucagon receptor modulators |
CN106279023A (en) * | 2015-05-12 | 2017-01-04 | 中国科学院上海药物研究所 | 3,4,5-tri-substituted pyrazolecarboxylic compounds, preparation method, pharmaceutical composition and purposes |
US10076504B2 (en) | 2014-06-12 | 2018-09-18 | Ligand Pharmaceuticals, Inc. | Glucagon antagonists |
WO2019160940A1 (en) | 2018-02-13 | 2019-08-22 | Ligand Pharmaceuticals Incorporated | Glucagon receptor antagonists |
US11077092B2 (en) | 2012-12-10 | 2021-08-03 | Merck Sharp & Dohme Corp. | Methods of treating diabetes by administering a glucagon receptor antagonist in combination with a cholesterol absorption inhibitor |
Families Citing this family (8)
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EP2346830B1 (en) * | 2008-09-15 | 2015-05-13 | Merck Sharp & Dohme Corp. | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use |
US8361959B2 (en) * | 2008-10-03 | 2013-01-29 | Merck Sharp & Dohme Corp. | Spiro-imidazolone derivatives as glucagon receptor antagonists |
US8324384B2 (en) | 2009-02-12 | 2012-12-04 | Merck Sharp & Dohme Corp. | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use |
US8318667B2 (en) | 2009-02-25 | 2012-11-27 | Merck Sharp & Dohme Corp. | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use |
US8735604B2 (en) | 2009-09-22 | 2014-05-27 | Merck Sharp & Dohme Corp. | Pyrrolidines as glucagon receptor antagonists, compositions, and methods for their use |
EP3065736B1 (en) | 2013-11-04 | 2018-11-14 | Merck Sharp & Dohme Corp. | Glucagon receptor antagonist compounds, compositions thereof, and methods of use |
TW201811752A (en) * | 2016-09-06 | 2018-04-01 | 比利時商健生藥品公司 | Indazole derivatives useful as glucagon receptor antagonists |
TWI757332B (en) * | 2016-09-06 | 2022-03-11 | 比利時商健生藥品公司 | Indazole derivatives useful as glucagon receptor antagonists |
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US6420427B1 (en) * | 1997-10-09 | 2002-07-16 | Ono Pharmaceutical Co., Ltd. | Aminobutyric acid derivatives |
WO2004069158A2 (en) * | 2003-01-27 | 2004-08-19 | Merck & Co., Inc. | Substituted pyrazoles, compositions containing such compounds and methods of use |
WO2005121097A2 (en) * | 2004-06-04 | 2005-12-22 | Merck & Co., Inc. | Pyrazole derivatives, compositions containing such compounds and methods of use |
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AR008789A1 (en) | 1996-07-31 | 2000-02-23 | Bayer Corp | PIRIDINES AND SUBSTITUTED BIPHENYLS |
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JP2001504489A (en) | 1996-11-20 | 2001-04-03 | メルク エンド カンパニー インコーポレーテッド | Triaryl-substituted imidazoles and methods of use |
WO1998022109A1 (en) | 1996-11-20 | 1998-05-28 | Merck & Co., Inc. | Triaryl substituted imidazoles as glucagon antagonists |
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CN1356977A (en) | 1999-05-17 | 2002-07-03 | 诺沃挪第克公司 | Glucagon antagonists/inverse agonists |
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-
2006
- 2006-07-21 EP EP06800239A patent/EP1910303A2/en not_active Withdrawn
- 2006-07-21 AU AU2006276072A patent/AU2006276072A1/en not_active Abandoned
- 2006-07-21 US US11/988,849 patent/US7709658B2/en active Active
- 2006-07-21 CA CA002614537A patent/CA2614537A1/en not_active Abandoned
- 2006-07-21 WO PCT/US2006/028545 patent/WO2007015999A2/en active Application Filing
- 2006-07-21 CN CNA2006800272230A patent/CN101300232A/en active Pending
- 2006-07-21 JP JP2008524008A patent/JP2009502923A/en not_active Withdrawn
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WO2004069158A2 (en) * | 2003-01-27 | 2004-08-19 | Merck & Co., Inc. | Substituted pyrazoles, compositions containing such compounds and methods of use |
WO2005121097A2 (en) * | 2004-06-04 | 2005-12-22 | Merck & Co., Inc. | Pyrazole derivatives, compositions containing such compounds and methods of use |
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Cited By (30)
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---|---|---|---|---|
US9169201B2 (en) | 2007-02-09 | 2015-10-27 | Metabasis Therapeutics, Inc. | Antagonists of the glucagon receptor |
US10807946B2 (en) | 2007-02-09 | 2020-10-20 | Metabasis Therapeutics, Inc. | Antagonists of the glucagon receptor |
US10239829B2 (en) | 2007-02-09 | 2019-03-26 | Metabasis Therapeutics, Inc. | Antagonists of the glucagon receptor |
US9701626B2 (en) | 2007-02-09 | 2017-07-11 | Metabasis Therapeutics, Inc. | Antagonists of the glucagon receptor |
US8710236B2 (en) | 2007-02-09 | 2014-04-29 | Metabasis Therapeutics, Inc. | Antagonists of the glucagon receptor |
US8232413B2 (en) | 2007-09-12 | 2012-07-31 | Merck Sharp & Dohme Corp. | Process for the production of a crystalline glucagon receptor antagonist compound |
WO2009035558A1 (en) * | 2007-09-12 | 2009-03-19 | Merck & Co., Inc. | Process for the production of a crystalline glucagon receptor antagonist compound |
US8623818B2 (en) | 2008-05-16 | 2014-01-07 | Merck Sharp & Dohme Corp. | Glucagon receptor antagonists, compositions, and methods for their use |
US9783494B2 (en) | 2008-08-13 | 2017-10-10 | Metabasis Therapeutics, Inc. | Glucagon antagonists |
EP2799428A2 (en) | 2008-08-13 | 2014-11-05 | Metabasis Therapeutics, Inc. | Glucagon antagonists |
US8907103B2 (en) | 2008-08-13 | 2014-12-09 | Metabasis Therapeutics, Inc. | Glucagon antagonists |
US11352321B2 (en) | 2008-08-13 | 2022-06-07 | Metabasis Therapeutics, Inc. | Glucagon antagonists |
US10221130B2 (en) | 2008-08-13 | 2019-03-05 | Metabasis Therapeutics, Inc. | Glucagon antagonists |
DE102008057718A1 (en) | 2008-11-17 | 2010-05-20 | Skw Stickstoffwerke Piesteritz Gmbh | Regioselective preparation of N-(1H-pyrazolyl methyl)amide compounds, useful e.g. as nitrification inhibitors, comprises reacting hydrazine methyl carboxylic acid amide compounds with 1,3-dicarbonyl compounds |
US8470773B2 (en) | 2009-06-12 | 2013-06-25 | Merck Sharp & Dohme Corp. | Thiophenes as glucagon receptor antagonists, compositions, and methods for their use |
WO2010144664A1 (en) * | 2009-06-12 | 2010-12-16 | Schering Corporation | Thiophenes as glucagon receptor antagonists, compositions, and methods for their use |
US9056834B2 (en) | 2010-12-23 | 2015-06-16 | Pfizer Inc. | Glucagon receptor modulators |
US8809342B2 (en) | 2010-12-23 | 2014-08-19 | Pfizer Inc. | Glucagon receptor modulators |
US8933104B2 (en) | 2010-12-23 | 2015-01-13 | Pfizer Inc. | Glucagon receptor modulators |
US8507533B2 (en) | 2011-02-08 | 2013-08-13 | Pfizer Inc. | Glucagon receptor modulators |
US9073871B2 (en) | 2011-02-08 | 2015-07-07 | Pfizer Inc. | Glucagon receptor modulators |
US8859591B2 (en) | 2011-02-08 | 2014-10-14 | Pfizer Inc. | Glucagon receptor modulators |
US9452999B2 (en) | 2011-02-08 | 2016-09-27 | Pfizer Inc. | Glucagon receptor modulators |
US9139538B2 (en) | 2011-07-22 | 2015-09-22 | Pfizer Inc. | Quinolinyl glucagon receptor modulators |
US8927577B2 (en) | 2011-07-22 | 2015-01-06 | Pfizer Inc. | Quinolinyl glucagon receptor modulators |
US11077092B2 (en) | 2012-12-10 | 2021-08-03 | Merck Sharp & Dohme Corp. | Methods of treating diabetes by administering a glucagon receptor antagonist in combination with a cholesterol absorption inhibitor |
US10076504B2 (en) | 2014-06-12 | 2018-09-18 | Ligand Pharmaceuticals, Inc. | Glucagon antagonists |
CN106279023A (en) * | 2015-05-12 | 2017-01-04 | 中国科学院上海药物研究所 | 3,4,5-tri-substituted pyrazolecarboxylic compounds, preparation method, pharmaceutical composition and purposes |
CN106279023B (en) * | 2015-05-12 | 2021-06-22 | 中国科学院上海药物研究所 | 3,4, 5-trisubstituted pyrazole compound, preparation method, pharmaceutical composition and application |
WO2019160940A1 (en) | 2018-02-13 | 2019-08-22 | Ligand Pharmaceuticals Incorporated | Glucagon receptor antagonists |
Also Published As
Publication number | Publication date |
---|---|
CN101300232A (en) | 2008-11-05 |
CA2614537A1 (en) | 2007-02-08 |
US7709658B2 (en) | 2010-05-04 |
EP1910303A2 (en) | 2008-04-16 |
JP2009502923A (en) | 2009-01-29 |
AU2006276072A1 (en) | 2007-02-08 |
US20090054662A1 (en) | 2009-02-26 |
WO2007015999A3 (en) | 2007-06-28 |
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