WO2007012838A3 - Drug delivery system - Google Patents

Drug delivery system Download PDF

Info

Publication number
WO2007012838A3
WO2007012838A3 PCT/GB2006/002772 GB2006002772W WO2007012838A3 WO 2007012838 A3 WO2007012838 A3 WO 2007012838A3 GB 2006002772 W GB2006002772 W GB 2006002772W WO 2007012838 A3 WO2007012838 A3 WO 2007012838A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptide
drug
delivery system
drug delivery
drug carrier
Prior art date
Application number
PCT/GB2006/002772
Other languages
French (fr)
Other versions
WO2007012838A2 (en
Inventor
Patrick Bailey
Original Assignee
Univ Manchester
Patrick Bailey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Manchester, Patrick Bailey filed Critical Univ Manchester
Publication of WO2007012838A2 publication Critical patent/WO2007012838A2/en
Publication of WO2007012838A3 publication Critical patent/WO2007012838A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent

Abstract

The invention relates to peptides and peptide analogues/derivatives, for use as peptide drug carrier molecules, and peptide drug carrier-drug conjugates which are transported across the wall of the gut into the blood by PepTl protein. There is provided a drug carrier comprising a peptide, or derivative or analogue thereof, the peptide comprising at least two amino acid residues linked by a peptide bond. The amino acid residues are arranged such that the peptide bond is protected from hydrolysis. The peptide comprises a functional group for attachment to a drug. The functional group to which the drug is attached is provided on the second or C-terminal residue of the peptide.
PCT/GB2006/002772 2005-07-27 2006-07-25 Drug delivery system WO2007012838A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0515363.0A GB0515363D0 (en) 2005-07-27 2005-07-27 Drug delivery system
GB0515363.0 2005-07-27

Publications (2)

Publication Number Publication Date
WO2007012838A2 WO2007012838A2 (en) 2007-02-01
WO2007012838A3 true WO2007012838A3 (en) 2007-05-03

Family

ID=34976643

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/002772 WO2007012838A2 (en) 2005-07-27 2006-07-25 Drug delivery system

Country Status (2)

Country Link
GB (1) GB0515363D0 (en)
WO (1) WO2007012838A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017156648A1 (en) * 2016-03-18 2017-09-21 广州诺威生物技术有限公司 Compound having anti-inflammatory effect
CN106279353A (en) * 2016-03-18 2017-01-04 广州诺威生物技术有限公司 A kind of compound for antiinflammatory

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003099338A2 (en) * 2002-05-17 2003-12-04 Xenoport, Inc. Amino acid conjugates providing for sustained systemic concentrations of gaba analogues

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003099338A2 (en) * 2002-05-17 2003-12-04 Xenoport, Inc. Amino acid conjugates providing for sustained systemic concentrations of gaba analogues

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BRODIN BIRGER; NIELSEN CARSTEN UHD; STEFFANSEN BENTE; FROKJAER SVEN: "Transport of peptidomimetic drugs by the intestinal Di/tri-peptide transporter, PepT1", PHARMACOLOGY & TOXICOLOGY, vol. 90, no. 6, June 2002 (2002-06-01), pages 285 - 296, XP002403283 *
LEPIST E I; KUSK T; LARSEN D H; ANDERSEN D; FROKJAER S; TAUB M E; VESKI P; LENNERNÄS H; FRIEDRICHSEN G; STEFFANSEN B: "Stability and in vitro metabolism of dipeptide model prodrugs with affinity for the oligopeptide transporter", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 11, no. 1, July 2000 (2000-07-01), pages 43 - 50, XP002403282 *
TAUB M E; DUE LARSEN B; STEFFANSEN B; FROKJAER S: "[beta]-Carboxylic acid esterified D-Asp-Ala retains a high affinity for the oligopeptide transporter in Caco-2 monolayers", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 146, no. 2, 15 January 1997 (1997-01-15), pages 205 - 212, XP002403281 *
THOMSEN AE; FRIEDRICHSEN GM; SORENSEN AH; ANDERSEN R; NIELSEN CU; BRODIN B; EGTRUP M; FROKJAER S; STEFFANSEN B: "Prodrugs of purine and pyrimidine analogues for the intestinal di/tri-peptide transporter PepT1: affinity for hPepT1 in Caco-2 cells, drug release in aqueous media and in vitro metabolism", JOURNAL OF CONTROLLED RELEASE, vol. 86, no. 2-3, 17 January 2003 (2003-01-17), pages 279 - 292, XP004401122 *

Also Published As

Publication number Publication date
WO2007012838A2 (en) 2007-02-01
GB0515363D0 (en) 2005-08-31

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