WO2007011910A3 - Chiral amine-catalyzed asymmetric addition of carbon-centered nucleophiles to imines - Google Patents

Chiral amine-catalyzed asymmetric addition of carbon-centered nucleophiles to imines Download PDF

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Publication number
WO2007011910A3
WO2007011910A3 PCT/US2006/027778 US2006027778W WO2007011910A3 WO 2007011910 A3 WO2007011910 A3 WO 2007011910A3 US 2006027778 W US2006027778 W US 2006027778W WO 2007011910 A3 WO2007011910 A3 WO 2007011910A3
Authority
WO
WIPO (PCT)
Prior art keywords
imines
carbon
chiral amine
catalyzed asymmetric
asymmetric addition
Prior art date
Application number
PCT/US2006/027778
Other languages
French (fr)
Other versions
WO2007011910A2 (en
Inventor
Scott Edward Schaus
Sha Lou
Amal Ting
Christine Bode
Brandon M Taoka
Peng Dai
Original Assignee
Univ Boston
Scott Edward Schaus
Sha Lou
Amal Ting
Christine Bode
Brandon M Taoka
Peng Dai
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Boston, Scott Edward Schaus, Sha Lou, Amal Ting, Christine Bode, Brandon M Taoka, Peng Dai filed Critical Univ Boston
Publication of WO2007011910A2 publication Critical patent/WO2007011910A2/en
Publication of WO2007011910A3 publication Critical patent/WO2007011910A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups

Abstract

The present invention relates to an asymmetric synthesis useful for preparing compounds useful for the treatment of cardiovascular diseases and for studying the role of motor proteins in cell cycle progression.
PCT/US2006/027778 2005-07-19 2006-07-19 Chiral amine-catalyzed asymmetric addition of carbon-centered nucleophiles to imines WO2007011910A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US70087005P 2005-07-19 2005-07-19
US60/700,870 2005-07-19
US77800006P 2006-03-01 2006-03-01
US60/778,000 2006-03-01

Publications (2)

Publication Number Publication Date
WO2007011910A2 WO2007011910A2 (en) 2007-01-25
WO2007011910A3 true WO2007011910A3 (en) 2007-09-20

Family

ID=37669491

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/027778 WO2007011910A2 (en) 2005-07-19 2006-07-19 Chiral amine-catalyzed asymmetric addition of carbon-centered nucleophiles to imines

Country Status (1)

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WO (1) WO2007011910A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5382350B2 (en) * 2007-12-10 2014-01-08 日産化学工業株式会社 Optically active dinickel complex and method for producing optically active amine using the same
WO2012087720A1 (en) * 2010-12-20 2012-06-28 Boehringer Ingelheim International Gmbh Methods of making diastereomeric organic compounds
CN105017099B (en) * 2015-07-15 2017-03-22 成都千禧莱医药科技有限公司 Sitagliptin chiral intermediate and asymmetric synthesis method thereof
EP3260446A1 (en) 2016-06-24 2017-12-27 Universitat de les Illes Balears Enantioselective synthesis of dihydropyrimidinones and hexahydropyrimidinones
WO2018166855A1 (en) 2017-03-16 2018-09-20 Basf Se Heterobicyclic substituted dihydroisoxazoles

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6566532B2 (en) * 2000-02-09 2003-05-20 Sumitomo Chemical Company, Limited Process for producing optically active hemiesters
US6844448B2 (en) * 1998-05-01 2005-01-18 President And Fellows Of Harvard College Main-group metal-based asymmetric catalysts and applications thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6844448B2 (en) * 1998-05-01 2005-01-18 President And Fellows Of Harvard College Main-group metal-based asymmetric catalysts and applications thereof
US6566532B2 (en) * 2000-02-09 2003-05-20 Sumitomo Chemical Company, Limited Process for producing optically active hemiesters

Also Published As

Publication number Publication date
WO2007011910A2 (en) 2007-01-25

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