WO2007011647A3 - Inhibiteurs de la kinesine mitotique - Google Patents

Inhibiteurs de la kinesine mitotique Download PDF

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Publication number
WO2007011647A3
WO2007011647A3 PCT/US2006/027217 US2006027217W WO2007011647A3 WO 2007011647 A3 WO2007011647 A3 WO 2007011647A3 US 2006027217 W US2006027217 W US 2006027217W WO 2007011647 A3 WO2007011647 A3 WO 2007011647A3
Authority
WO
WIPO (PCT)
Prior art keywords
inhibitors
mitotic kinesin
kinesin ksp
ksp
mitotic
Prior art date
Application number
PCT/US2006/027217
Other languages
English (en)
Other versions
WO2007011647A2 (fr
Inventor
Anthony B Pinkerton
Robert L David
Original Assignee
Kalypsys Inc
Anthony B Pinkerton
Robert L David
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kalypsys Inc, Anthony B Pinkerton, Robert L David filed Critical Kalypsys Inc
Publication of WO2007011647A2 publication Critical patent/WO2007011647A2/fr
Publication of WO2007011647A3 publication Critical patent/WO2007011647A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

L'invention se rapporte à des composés et à des procédés qui peuvent servir d'inhibiteurs de la kinésine KSP, pour le traitement ou la prévention des maladies prolifératives cellulaires.
PCT/US2006/027217 2005-07-15 2006-07-13 Inhibiteurs de la kinesine mitotique WO2007011647A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US69952105P 2005-07-15 2005-07-15
US60/699,521 2005-07-15
US76161306P 2006-01-24 2006-01-24
US60/761,613 2006-01-24

Publications (2)

Publication Number Publication Date
WO2007011647A2 WO2007011647A2 (fr) 2007-01-25
WO2007011647A3 true WO2007011647A3 (fr) 2007-05-18

Family

ID=37622033

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/027217 WO2007011647A2 (fr) 2005-07-15 2006-07-13 Inhibiteurs de la kinesine mitotique

Country Status (1)

Country Link
WO (1) WO2007011647A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190016680A1 (en) 2016-01-14 2019-01-17 Beth Israel Deaconess Medical Center, Inc. Mast-cell modulators and uses thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003079973A2 (fr) * 2002-03-08 2003-10-02 Merck & Co., Inc. Inhibiteurs de kinesine mitotique
WO2006002236A1 (fr) * 2004-06-18 2006-01-05 Novartis Vaccines And Diagnostics Inc. Derives de n-(1-(1-benzyl-4-phenyl-1h-imidazol-2-yl)-2,2-dymethylpropyl) benzamide et composes associes comme inhibiteurs de la proteine kinesine fuseau (ksp) pour le traitement du cancer
WO2006031607A2 (fr) * 2004-09-13 2006-03-23 Merck & Co., Inc. Methode de traitement du cancer
WO2006068933A2 (fr) * 2004-12-21 2006-06-29 Merck & Co., Inc. Inhibiteurs de la kinesine mitotique
WO2006098962A1 (fr) * 2005-03-09 2006-09-21 Schering Corporation Composes inhibant l'activite de la kinesine ksp
WO2006098961A2 (fr) * 2005-03-09 2006-09-21 Schering Corporation Composes servant a inhiber l'activite de la kinesine ksp

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003079973A2 (fr) * 2002-03-08 2003-10-02 Merck & Co., Inc. Inhibiteurs de kinesine mitotique
WO2006002236A1 (fr) * 2004-06-18 2006-01-05 Novartis Vaccines And Diagnostics Inc. Derives de n-(1-(1-benzyl-4-phenyl-1h-imidazol-2-yl)-2,2-dymethylpropyl) benzamide et composes associes comme inhibiteurs de la proteine kinesine fuseau (ksp) pour le traitement du cancer
WO2006031607A2 (fr) * 2004-09-13 2006-03-23 Merck & Co., Inc. Methode de traitement du cancer
WO2006068933A2 (fr) * 2004-12-21 2006-06-29 Merck & Co., Inc. Inhibiteurs de la kinesine mitotique
WO2006098962A1 (fr) * 2005-03-09 2006-09-21 Schering Corporation Composes inhibant l'activite de la kinesine ksp
WO2006098961A2 (fr) * 2005-03-09 2006-09-21 Schering Corporation Composes servant a inhiber l'activite de la kinesine ksp

Also Published As

Publication number Publication date
WO2007011647A2 (fr) 2007-01-25

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