WO2007010412A3 - Syntheses and preparations of narwedine and related novel compounds - Google Patents

Syntheses and preparations of narwedine and related novel compounds Download PDF

Info

Publication number
WO2007010412A3
WO2007010412A3 PCT/IB2006/002875 IB2006002875W WO2007010412A3 WO 2007010412 A3 WO2007010412 A3 WO 2007010412A3 IB 2006002875 W IB2006002875 W IB 2006002875W WO 2007010412 A3 WO2007010412 A3 WO 2007010412A3
Authority
WO
WIPO (PCT)
Prior art keywords
narwedine
novel compounds
galanthamine
syntheses
preparations
Prior art date
Application number
PCT/IB2006/002875
Other languages
French (fr)
Other versions
WO2007010412A2 (en
Inventor
Suarez Gabriel Tojo
Lopez Ernesto Duran
I Llado Jordi Bosch
Original Assignee
Medichem Sa
Suarez Gabriel Tojo
Lopez Ernesto Duran
I Llado Jordi Bosch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medichem Sa, Suarez Gabriel Tojo, Lopez Ernesto Duran, I Llado Jordi Bosch filed Critical Medichem Sa
Priority to AT06809025T priority Critical patent/ATE459627T1/en
Priority to DE602006012660T priority patent/DE602006012660D1/en
Priority to CA002607811A priority patent/CA2607811A1/en
Priority to EP06809025A priority patent/EP1885727B1/en
Priority to US11/913,649 priority patent/US20080306257A1/en
Publication of WO2007010412A2 publication Critical patent/WO2007010412A2/en
Publication of WO2007010412A3 publication Critical patent/WO2007010412A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention relates to a process for preparing racemic narwedine (which can be can be kinetically resolved to yield (-)-narwedine and which is the biogenic precursor of (-)- galanthamine) and the use thereof as a starting material for producing (-)-galanthamine. The invention further includes processes for preparing (-)-galanthamine and (-)-galanthamine hydrobromide, as well as related novel compounds.
PCT/IB2006/002875 2005-05-03 2006-05-03 Syntheses and preparations of narwedine and related novel compounds WO2007010412A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AT06809025T ATE459627T1 (en) 2005-05-03 2006-05-03 SYNTHESIS AND PREPARATIONS OF NARWEDINE AND RELATED NEW COMPOUNDS
DE602006012660T DE602006012660D1 (en) 2005-05-03 2006-05-03 SYNTHESIS AND PREPARATIONS OF NARWEDIN AND RELATED NEW COMPOUNDS
CA002607811A CA2607811A1 (en) 2005-05-03 2006-05-03 Syntheses and preparations of narwedine and related novel compounds
EP06809025A EP1885727B1 (en) 2005-05-03 2006-05-03 Syntheses and preparations of narwedine and related novel compounds
US11/913,649 US20080306257A1 (en) 2005-05-03 2006-05-03 Syntheses and Preparations of Narwedine and Related Novel Compounds

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US67696405P 2005-05-03 2005-05-03
US60/676,964 2005-05-03
US72201505P 2005-09-30 2005-09-30
US60/722,015 2005-09-30

Publications (2)

Publication Number Publication Date
WO2007010412A2 WO2007010412A2 (en) 2007-01-25
WO2007010412A3 true WO2007010412A3 (en) 2007-08-30

Family

ID=37591720

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/002875 WO2007010412A2 (en) 2005-05-03 2006-05-03 Syntheses and preparations of narwedine and related novel compounds

Country Status (7)

Country Link
US (1) US20080306257A1 (en)
EP (1) EP1885727B1 (en)
AR (1) AR054753A1 (en)
AT (1) ATE459627T1 (en)
CA (1) CA2607811A1 (en)
DE (1) DE602006012660D1 (en)
WO (1) WO2007010412A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101674835B (en) 2007-04-12 2013-12-11 台湾神隆股份有限公司 Process for making galantamine
CN102304031A (en) * 2011-05-13 2012-01-04 华东理工大学 Benzaldehyde derivative and use thereof in preparation of galanthamine
BG67337B1 (en) * 2018-05-23 2021-06-15 Софарма Ад Method for preparation of purified galantamine hydrobromide
CN109336897A (en) * 2018-12-06 2019-02-15 河南中帅医药科技股份有限公司 A kind of galanthamine hydrobromide industrialized process for preparing
CN109305973A (en) * 2018-12-06 2019-02-05 河南中帅医药科技股份有限公司 A kind of preparation method and application of galanthamine hydrobromide crystal form

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996031458A1 (en) * 1995-04-03 1996-10-10 Chiroscience Limited Oxidative process for preparing narwedine derivatives
US6043359A (en) * 1994-10-21 2000-03-28 Sanochemia Pharmazeutica Aktiengesellschaft Processes for the preparation of derivatives of 4a,5,9,10,11,12-hexahydro-6H-benzofuro-[3a,3,2-ef][2]benzazepine
WO2006072818A2 (en) * 2005-01-04 2006-07-13 Emcure Pharmaceuticals Limited Process for preparation of galanthamine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6043359A (en) * 1994-10-21 2000-03-28 Sanochemia Pharmazeutica Aktiengesellschaft Processes for the preparation of derivatives of 4a,5,9,10,11,12-hexahydro-6H-benzofuro-[3a,3,2-ef][2]benzazepine
WO1996031458A1 (en) * 1995-04-03 1996-10-10 Chiroscience Limited Oxidative process for preparing narwedine derivatives
WO2006072818A2 (en) * 2005-01-04 2006-07-13 Emcure Pharmaceuticals Limited Process for preparation of galanthamine

Also Published As

Publication number Publication date
DE602006012660D1 (en) 2010-04-15
US20080306257A1 (en) 2008-12-11
EP1885727A2 (en) 2008-02-13
ATE459627T1 (en) 2010-03-15
WO2007010412A2 (en) 2007-01-25
AR054753A1 (en) 2007-07-11
EP1885727B1 (en) 2010-03-03
CA2607811A1 (en) 2007-01-25

Similar Documents

Publication Publication Date Title
WO2009102155A3 (en) Process for preparation of 2-methyl-2´-phenylpropionic acid derivatives and novel intermediate compounds
WO2008089984A3 (en) Process for the preparation of ezetimibe and derivatives thereof
WO2007035629A3 (en) Process for the preparation of pyrimidinedione derivatives
WO2009036281A3 (en) Bortezomib and process for producing same
TW200716582A (en) Process for making a pharmaceutical compound
WO2009120774A3 (en) Method of preparing huperzine a and derivatives thereof
WO2010116140A8 (en) New process for preparing hydroxylamines and medicaments
WO2007010412A3 (en) Syntheses and preparations of narwedine and related novel compounds
WO2008015696A3 (en) Process for preparing ciclesonide
WO2006010620A3 (en) Olanzapine salts and their conversion to olanzapine free base
WO2007003200A3 (en) High yield synthesis methods for producing organic salts of strontium
TW200738650A (en) Process for synthesis of aryloxy diaminopyrimidines
WO2009075516A3 (en) Process for preparing pantoprazole sodium sesquihydrate
WO2007026373A3 (en) Process for preparing rivastigmine
WO2005012227A3 (en) Process for preparation of 2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethyl-phenol, a metabolite of tolterodine
WO2009021943A3 (en) Novel preparation process
WO2005085243A3 (en) Process for the preparation of cabergoline
WO2005063731A3 (en) Production of dihydronepetalactone by reduction of nepetalic acid
WO2006008302A3 (en) Improved process for the manufacture of mirtazapine
GB0417063D0 (en) Process for the preparation of optically-active compounds
WO2008006720A3 (en) Crystalline nemorubicin hydrochloride
WO2007015259A3 (en) Method of synthesizing key intermediates for the production of camptothecin derivatives
NZ589496A (en) Processes and compounds for the preparation of normorphinans
WO2007044490A3 (en) Process for making heteroaryl amine intermediate compounds
WO2007041273A3 (en) Process for the production of intermediates for making prostaglandin derivatives such as latanoprost, travaprost, and bimatoprost

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 2607811

Country of ref document: CA

NENP Non-entry into the national phase

Ref country code: DE

WWW Wipo information: withdrawn in national office

Country of ref document: DE

NENP Non-entry into the national phase

Ref country code: RU

WWE Wipo information: entry into national phase

Ref document number: 2006809025

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Country of ref document: RU

WWP Wipo information: published in national office

Ref document number: 2006809025

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 11913649

Country of ref document: US