WO2007009457A3 - Identification of protein ligands modifying a cellular response - Google Patents

Identification of protein ligands modifying a cellular response Download PDF

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Publication number
WO2007009457A3
WO2007009457A3 PCT/DK2006/000410 DK2006000410W WO2007009457A3 WO 2007009457 A3 WO2007009457 A3 WO 2007009457A3 DK 2006000410 W DK2006000410 W DK 2006000410W WO 2007009457 A3 WO2007009457 A3 WO 2007009457A3
Authority
WO
WIPO (PCT)
Prior art keywords
cellular response
identification
modifying
protein ligands
screening
Prior art date
Application number
PCT/DK2006/000410
Other languages
French (fr)
Other versions
WO2007009457A2 (en
Inventor
Ole Thastrup
Grith Hagel
Hilaire Phaedria Marie St
Jens Chr Norrild
Original Assignee
2Curex Aps
Ole Thastrup
Grith Hagel
Hilaire Phaedria Marie St
Jens Chr Norrild
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 2Curex Aps, Ole Thastrup, Grith Hagel, Hilaire Phaedria Marie St, Jens Chr Norrild filed Critical 2Curex Aps
Publication of WO2007009457A2 publication Critical patent/WO2007009457A2/en
Publication of WO2007009457A3 publication Critical patent/WO2007009457A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to a method for identifying protein ligands capable of modulating a cellular response. The method furthermore enables identification of the protein(s) binding to the identified ligand. The method may in particular be useful in drug screening processes and allows screening for biological activity and for drug targets in a high through-put screening format.
PCT/DK2006/000410 2005-07-18 2006-07-12 Identification of protein ligands modifying a cellular response WO2007009457A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200501068 2005-07-18
DKPA200501068 2005-07-18

Publications (2)

Publication Number Publication Date
WO2007009457A2 WO2007009457A2 (en) 2007-01-25
WO2007009457A3 true WO2007009457A3 (en) 2007-05-24

Family

ID=37159296

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2006/000410 WO2007009457A2 (en) 2005-07-18 2006-07-12 Identification of protein ligands modifying a cellular response

Country Status (1)

Country Link
WO (1) WO2007009457A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2472563B (en) * 2009-04-28 2013-02-27 Univ Leicester Method of preparing hairpin and cyclic polyamides
KR20120093151A (en) * 2009-07-15 2012-08-22 에이전시 포 사이언스, 테크놀로지 앤드 리서치 Improved screening of biopolymers
CN102648312B (en) 2009-07-22 2014-03-05 新加坡科技研究局 Differentiation of isobaric amino acids and other species

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005045430A1 (en) * 2003-10-08 2005-05-19 The Regents Of The University Of California Screening combinatorial bead libraries for cancer ligands
WO2005116656A1 (en) * 2004-05-25 2005-12-08 2Curex Identification of compounds modifying a cellular response

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005045430A1 (en) * 2003-10-08 2005-05-19 The Regents Of The University Of California Screening combinatorial bead libraries for cancer ligands
WO2005116656A1 (en) * 2004-05-25 2005-12-08 2Curex Identification of compounds modifying a cellular response
WO2005116643A2 (en) * 2004-05-25 2005-12-08 Carlsberg A/S Identification of compounds modifying a cellular response

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
AINA OLULANU H ET AL: "Identification of novel targeting peptides for human ovarian cancer cells using "one-bead one-compound" combinatorial libraries.", MOLECULAR CANCER THERAPEUTICS. MAY 2005, vol. 4, no. 5, May 2005 (2005-05-01), pages 806 - 813, XP002405735, ISSN: 1535-7163 *
PETERS JENNIFER L ET AL: "Melatonin modulates intercellular communication among cultured chick astrocytes.", BRAIN RESEARCH. 7 JAN 2005, vol. 1031, no. 1, 7 January 2005 (2005-01-07), pages 10 - 19, XP002405734, ISSN: 0006-8993 *
REZAEE MEHRDAD ET AL: "Del1 mediates VSMC adhesion, migration, and proliferation through interaction with integrin alpha(v)beta(3).", AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY. MAY 2002, vol. 282, no. 5, May 2002 (2002-05-01), pages H1924 - H1932, XP002405733, ISSN: 0363-6135 *

Also Published As

Publication number Publication date
WO2007009457A2 (en) 2007-01-25

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