WO2007008514A3 - Inhibitors of glycogen synthase kinase 3 - Google Patents

Inhibitors of glycogen synthase kinase 3 Download PDF

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Publication number
WO2007008514A3
WO2007008514A3 PCT/US2006/026137 US2006026137W WO2007008514A3 WO 2007008514 A3 WO2007008514 A3 WO 2007008514A3 US 2006026137 W US2006026137 W US 2006026137W WO 2007008514 A3 WO2007008514 A3 WO 2007008514A3
Authority
WO
WIPO (PCT)
Prior art keywords
glycogen synthase
synthase kinase
relates
disease
present
Prior art date
Application number
PCT/US2006/026137
Other languages
French (fr)
Other versions
WO2007008514A2 (en
Inventor
Alan P Kozikowski
Irina Gaysina
Pavel Petukhov
Jayalakshmi Sridhar
Werner Tueckmantel
Original Assignee
Univ Georgetown
Alan P Kozikowski
Irina Gaysina
Pavel Petukhov
Jayalakshmi Sridhar
Werner Tueckmantel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Georgetown, Alan P Kozikowski, Irina Gaysina, Pavel Petukhov, Jayalakshmi Sridhar, Werner Tueckmantel filed Critical Univ Georgetown
Publication of WO2007008514A2 publication Critical patent/WO2007008514A2/en
Publication of WO2007008514A3 publication Critical patent/WO2007008514A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

One aspect of the present invention relates to heterocyclic compounds that inhibit mammalian or human glycogen synthase kinase 3. Another aspect of the invention relates to pharmaceutical compositions comprising such a heterocyclic compound. The present invention also relates to methods of treating a mammal or human suffering from a malady that is based at least in part on abnormal activity of glycogen synthase kinase 3. The present invention also relates to methods of treating a mammal or human suffering from diabetes, Alzheimer's disease, Huntington's disease, Parkinson's disease, AIDS-associated dementia, ALS, MS, or schizophrenia.
PCT/US2006/026137 2005-07-07 2006-07-06 Inhibitors of glycogen synthase kinase 3 WO2007008514A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US69708405P 2005-07-07 2005-07-07
US60/697,084 2005-07-07
US71727705P 2005-09-15 2005-09-15
US60/717,277 2005-09-15

Publications (2)

Publication Number Publication Date
WO2007008514A2 WO2007008514A2 (en) 2007-01-18
WO2007008514A3 true WO2007008514A3 (en) 2007-10-04

Family

ID=37637714

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/026137 WO2007008514A2 (en) 2005-07-07 2006-07-06 Inhibitors of glycogen synthase kinase 3

Country Status (1)

Country Link
WO (1) WO2007008514A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9486441B2 (en) 2008-04-21 2016-11-08 Signum Biosciences, Inc. Compounds, compositions and methods for making the same

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2125683B1 (en) 2006-12-19 2013-10-23 The Board of Trustees of the University of Illinois 3-benzofuranyl-4-indolyl-maleimides as potent gsk-3 inhibitors for neurodegenerative disorders
UY34072A (en) 2011-05-17 2013-01-03 Novartis Ag INDOL SUBSTITUTED DERIVATIVES
JP2016508962A (en) * 2012-12-10 2016-03-24 セントジーン アーゲー Use of maleimide derivatives to prevent and treat cancer
EP2928466B1 (en) * 2012-12-10 2020-10-28 Centogene GmbH Use of maleimide derivatives for preventing and treating leukemia
ES2832456T3 (en) 2015-04-24 2021-06-10 Lubrizol Advanced Mat Inc Surface Modified Polymer Compositions
CN106699739B (en) * 2016-12-16 2019-03-12 浙江工业大学上虞研究院有限公司 3- indoles -4- indazole maleimide compound and its preparation method and application
WO2020163812A1 (en) 2019-02-08 2020-08-13 Frequency Therapeutics, Inc. Valproic acid compounds and wnt agonists for treating ear disorders

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6849643B2 (en) * 2000-12-08 2005-02-01 Ortho-Mcneil Pharmaceutical, Inc. Indazolyl-substituted pyrroline compounds as kinase inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6849643B2 (en) * 2000-12-08 2005-02-01 Ortho-Mcneil Pharmaceutical, Inc. Indazolyl-substituted pyrroline compounds as kinase inhibitors

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9486441B2 (en) 2008-04-21 2016-11-08 Signum Biosciences, Inc. Compounds, compositions and methods for making the same

Also Published As

Publication number Publication date
WO2007008514A2 (en) 2007-01-18

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