WO2007006843A1 - Micromechanical sensor, sensor array and method - Google Patents
Micromechanical sensor, sensor array and method Download PDFInfo
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- WO2007006843A1 WO2007006843A1 PCT/FI2006/000240 FI2006000240W WO2007006843A1 WO 2007006843 A1 WO2007006843 A1 WO 2007006843A1 FI 2006000240 W FI2006000240 W FI 2006000240W WO 2007006843 A1 WO2007006843 A1 WO 2007006843A1
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- wave guide
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Classifications
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- H—ELECTRICITY
- H03—ELECTRONIC CIRCUITRY
- H03H—IMPEDANCE NETWORKS, e.g. RESONANT CIRCUITS; RESONATORS
- H03H9/00—Networks comprising electromechanical or electro-acoustic devices; Electromechanical resonators
- H03H9/02—Details
- H03H9/02007—Details of bulk acoustic wave devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
- B81B7/00—Microstructural systems; Auxiliary parts of microstructural devices or systems
- B81B7/04—Networks or arrays of similar microstructural devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
- G01N29/02—Analysing fluids
- G01N29/022—Fluid sensors based on microsensors, e.g. quartz crystal-microbalance [QCM], surface acoustic wave [SAW] devices, tuning forks, cantilevers, flexural plate wave [FPW] devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
- G01N29/02—Analysing fluids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
- G01N29/02—Analysing fluids
- G01N29/036—Analysing fluids by measuring frequency or resonance of acoustic waves
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
- G01N29/22—Details, e.g. general constructional or apparatus details
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
- G01N29/22—Details, e.g. general constructional or apparatus details
- G01N29/24—Probes
- G01N29/2462—Probes with waveguides, e.g. SAW devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
- G01N29/22—Details, e.g. general constructional or apparatus details
- G01N29/30—Arrangements for calibrating or comparing, e.g. with standard objects
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
- H01L21/00—Processes or apparatus adapted for the manufacture or treatment of semiconductor or solid state devices or of parts thereof
- H01L21/02—Manufacture or treatment of semiconductor devices or of parts thereof
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
- B81B2201/00—Specific applications of microelectromechanical systems
- B81B2201/02—Sensors
- B81B2201/0292—Sensors not provided for in B81B2201/0207 - B81B2201/0285
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2291/00—Indexing codes associated with group G01N29/00
- G01N2291/02—Indexing codes associated with the analysed material
- G01N2291/025—Change of phase or condition
- G01N2291/0255—(Bio)chemical reactions, e.g. on biosensors
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- G—PHYSICS
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- G01N2291/106—Number of transducers one or more transducer arrays
Definitions
- the present invention relates to sensors.
- the present invention concerns mi- cromechanically fabricated sensors that are manufactured on semiconductor substrates. Such sensors can be used for analyzing, for example, small amounts of biological matter.
- the invention also concerns a method for analyzing liquid phase samples micromechani- cally.
- micro-on-insulator SOI
- the recent research related to molecule-specific membranes [Vikholml-4] has expanded the possibilities of micromechanically imple- mented biochemical analysis. It is well known that the biochemical analysis can be made by using micromechanical resonators, whose resonant frequency is altered by changes on the surface mass of the sensor. By monitoring the resonant frequency, information on the substance on the sensor is obtained.
- the resolution of detecting a small change in mass is inversely proportional to the effective mass of the resonator and directly proportional to the resonant frequency and the Q-value of the resonator.
- the resolution is proportional to the displacement amplitude of the resonator.
- SAWs surface acoustic waves
- the SAW devices usually oscillate either in vertical or horizontal direction transverse to the propagation direction of the waves.
- the dis- placement of the surface of vertical mode SAW sensors is big, which makes them less suitable for analyzing of liquid samples. In particular, detection of small mass changes is difficult from liquid samples. This is because the oscillations are easily damped due to the vibrational energy radiated/lost to the liquid.
- Shear-Horizontal SAW (SH-SAW) sensors have been utilized as liquid phase sensors, though, as they utilize parallel-to-surface transverse waves.
- a SAW silicon micromechanical resonator utilizing a flexural wave mode can also be used but it is also suitable only for gas phase analysis.
- TSMs Thickness Shear Mode BAW Resonators
- SH-APM Shear-Horizontal Acoustic Plate Mode Sensors
- any mechanical resonator can successfully be applied for measuring mass growth on the surface if placed in gas.
- two problems arise. First, only sealed structures can be used. That is, the liquid-receiving section of the sensor has to be mechanically isolated from the other parts of the structure, such as transducer elements. Second, mechanical oscillations will be heavily damped by dissipations related to the liq- uid sample. Such dissipations result, for example, from relatively high masses of liquid- phase samples and viscous properties of the liquid, as well as from the relatively similar acoustic impedances of resonator materials and the liquid (typically within a decade).
- the invention is based on the idea of using longitudinal bulk acoustic waves for detecting phenomena occurring in a sample, especially a liquid phase sample, by micromechanical arrangement.
- a sensor according to the invention is manufactured on a substrate (body) and it exhibits a wave guide portion for carrying the acoustic waves.
- the wave guide portion is located at a distance from the body.
- the wave guide portion is also provided with a sample-receiving area on at least one of its surfaces.
- the longitudinal bulk acoustic waves are produced by at least one electro-mechanical transducer element located in the vicinity of the wave guide portion.
- the method according to the invention comprises the steps of introducing a liquid sample on a sample-receiving area of a micromechanical wave guide and transmitting longitudinal bulk acoustic waves into the wave guide using an electro-mechanical coupling, and converting the acoustic waves into electrical signals for sensing the impact of the sample on the vibrational behaviour of the wave guide.
- a sensor or multiple sensors according to the invention can be incorporated into an array of several micromechanical acoustic sensor elements.
- the invention is characterized by what is stated in the characterizing part of claim 1.
- the sensor array is mainly characterized by what is stated in the characterizing part of claim 29.
- the method array is characterized by what is stated in claim 34.
- the surface-normal component of displacement remains minor as a result of the bulk wave propagating in longitudinal direction.
- the contraction and expansion caused by the Poisson's effect in the vertical (perpendicular-to-surface) direction remains small.
- the surface-normal component of displacement can be made extremely small by appropriate cutting of the single crystal silicon.
- the surface-normal component of displacement is expected to be reduced even further, and thus also the losses due to acoustic radiation to the liquid.
- a typical SOI-device layer thickness in the order of 10-30 ⁇ m makes the bulk acoustic wave propagation suitably sensitive to any changes in the physical properties of the sample-receiving area.
- the sample-receiving area is provided with a molecule- specific layer (MSL)
- MSL molecule-specific layer
- the alterations in the properties of the MSL are easily detectable.
- the structure is thick enough to contain sufficient energy in contrast to the surface acoustic wave (SAW) devices where excessive damping can occur due to the inevitable viscous loading by the liquid.
- SAW surface acoustic wave
- the electro-mechanical conversion can be realized, for example, by using narrow-gap capacitive transducers, piezoelectric transducers, magnetic transducers or thermal transducers.
- a standing-wave operation can be utilized in the device for improved coupling and resolution.
- micromechanical silicon-based components provide intrinsic potential for batch-fabricated sensor devices - including sensor arrays or matrices - with integrated readout electronics. Silicon-based sensors and the readout and actuation electronics could, in principle, be incorporated into any common integrated circuit (IC) structure. Sensors for different chemical and biological analysis can be implemented by applying different molecule-specific membranes (with low non-specific binding). Non-specific binding, temperature compensation and other interference phenomena can be eliminated by using integrated reference devices.
- At least the sample-receiving zone of the resonator is open to the exteriors of the device.
- Either an open front side of the resonator (wave guide portion) or a back side of the resonator in the interior of the device can be used for receiving the sample, depending on the embodiment.
- an "open" structure we mean such a solution, where the sample can be introduced to the sample-receiving zone directly, or through an opening in the device.
- the sensor or a plurality of sensors can be packed in a housing having a sealed portion or a plurality of such portions, which can be penetrated for sample introduction.
- the housing can be, for example, a ceramic or plastic casing typically used in semiconductor industry.
- the described structures allow - isolation of the liquid sample from the open structures required for capacitive electromechanical coupling
- the sensor can be used in various branches of industry and business. Examples of potential application areas of the embodiments of the invention include:
- medical diagnostic e.g. rapid diagnostics tests at doctors office
- flavour compounds - drug development
- lateral is used for describing the directions parallel to the sample-receiving surface of the wave guide.
- planar wave guide portion and “planar resonator”, we mean a thin (laminar) structure capable of carrying bulk acoustic waves actuated and sensed by the transducer elements located essentially in the vicinity of the fringe area (lateral sides) of the resonator.
- the resonator does not have to be uniformly even, but can have a variable thickness and/or sample-receiving surface geometry.
- Figure 1 shows a cross-sectional side view of a sensor according to an embodiment of the invention
- Figure 2 illustrates a lateral view of a sensor according to an embodiment of the invention
- Figure 3 shows an array of sensors according to an embodiment of the invention
- Figure 4 depicts a cross-sectional side view of a sensor having a capillary sample injection tube
- Figure 5 depicts a cross-sectional side view of a sensor having a modified base layer for sample injection
- Figure 6 shows a lateral view of a sensor kernel according to an embodiment of the invention
- Figure 7 shows simulation data obtained by exciting an acoustic mode exhibiting five different node position close to the center area of the resonator
- Figure 8 depicts a cross-sectional side view of a sensor according to another embodiment of the invention
- Figure 9 depicts a cross-sectional side view of a sensor according to yet another embodi- ment of the invention
- Figure 10 shows a lateral view of a sensor kernel according to another embodiment of the invention.
- Figure 11 illustrates a molecule-specific sensor and a reference sensor coupled for reference measurement
- Figure 12 illustrates a multiple-sensor configuration according to an embodiment of the invention
- Figures 13a - 13c shows three different simulated mode structures (oscillation amplitudes) of a square-shaped resonator
- Figure 14 shows an exemplary simulated mode structure (oscillation amplitude) of an elongated resonator
- Figures 15a and 15b show total and surface-normal oscillations, respectively, of another mode excited to a rectangular resonator
- Figures 16a and 16b show total and surface-normal oscillations, respectively, of yet another mode excited to a rectangular resonator.
- the senor is manufactured from a semiconductor- on-insulator, preferably a silicon-on-insulator (SOI) wafer.
- the body of the wafer is also preferably made of a semiconductor material, such as silicon, but also other materials, such as glass or other insulators, can be used.
- SOI silicon-on-insulator
- the crystal (lattice) structure of the semiconductor layer forming the device layer of the wafer has to be such that it can carry longitudinal acoustic waves. A lattice structure and cutting of crystal resulting in isotropic or anisotropic propagation of waves in the two lateral directions can also be used.
- the number of transducers may vary, for example, from 1 to 4. That is, the same transducer can be used for both transmitting and receiving the acoustic signals or separate transmitters and receivers can be used.
- the device comprises two or four transducers placed, for example, on each end of a rectangular resonator.
- Fig. 1 illustrates schematically a structure of a first embodiment of the sensor.
- the sensor device is manufactured on a semiconductor body 100.
- Electric electrodes 110 forming a part of the transducer elements of the device are separated from the body 100 by insulator layers 112.
- the longitudinal bulk acoustic wave is generated and detected using electromechanical piezoactive transducers 108 coupled between the electrodes 110 and a wave guide 106.
- the wave guide 106 and the electrodes 110 are formed by a released section in the device layer of a silicon-on-insulator (SOI) wafer 190.
- SOI silicon-on-insulator
- a molecule specific layer (MSL) 104 can be deposited on top of the wave guide. If the liquid sample 101 contains molecules matching the MSL, the physical properties of the MSL change, which causes a detectable change in the bulk acoustic wave propagation. Both the speed and dissipation of the wave can be affected by a change of the surface layer. Generally, the speed can be detected by detecting the resonant frequency and the dissipations via the Q-value of the resonator.
- an MSL layer comprises a ground matrix having a capacity for preventing non- specific binding.
- a layer can comprise hydrophilic polymer covalently bound to a buffer layer (e.g. of gold through sulphur bonds) and partly embedded specific (bio)molecules.
- the specific molecules have to be at least partly situated on the sample- receiving surface of the MSL layer.
- the specific molecules are typically antibodies or their Fab-fragments.
- the specific molecules can be bound to the subbing layer covalently.
- the thickness of such an MSL coating is typically only 4 - 10 nm.
- the specific parts of the MSL are synthetically prepared (molecular imprinted polymers).
- the MSL on the sample-receiving surface of the resonator can be carried out in a process step closely related to the manufacturing of the device, for example, by SOI- technology.
- the MSL can also be applied in a unit process.
- sensors can be manufactured without knowing the special applications of the end users.
- the MSL coating can be applied with a suitable apparatus on the sensor directly to the resonator or through openings in the sensor structure. If the sensor is tightly encased, the MSL is preferably applied before the sealing of the casing.
- the buffer layer can also be applied in the manufacturing phase of the device or in a later phase.
- the body 100 and the device layer of the wafer are preferably made of Silicon (Si), but also other semiconductor (and the like) materials, such as Germanium (Ge), Gallium- Arsenide (GaAs), diamond and sapphire can be considered is some applications.
- silicon carbide (SiC) may be applicable for some purposes, maintaining some of the benefits of Silicon, namely good processability and IC-compatibility.
- the body and the device layer can also be of different materials.
- beneficial properties of the wave guide material (the device layer) are low internal losses (high Q), high Young's modulus, and good thermal properties. If capacitive actuation is used, the device layer should also have high conductivity.
- the semiconductor layer can also be doped, for example, to increase its conductivity.
- the insulator layer can be a buried oxide (BOX) layer formed of, for example, quartz (SiO 2 ).
- Fig. 2 the structure of Fig. 1 is illustrated using a top view.
- the wave guide portion 206 is rectangular, enabling equal standing sound waves to be carried in both lateral directions (white arrows, only one pair of electrodes shown).
- standing wave (resonance) condition the length of the resonator plate is such, that it equals a half of the wave length ⁇ (or its multiple) of the desired acoustic frequency in the medium of the wave guide.
- the MSL is denoted with a reference number 204.
- Fig. 2 also depicts mechanical supports 214, which can be attached for example to each corner of the wave guide portion 206.
- the supports 214 are preferably such that they do not significantly interact with the propagating wave.
- insulator supports can be used. These types of supports are illustrated in the context of forthcoming embodiments referring to Figs. 4, 5, 8 and 9.
- Acoustic frequencies are typically in the range of 2 - 20 MHz, preferably 5 - 15 MHz,de- pending on the amount and properties (especially the viscous properties) of the sample and the properties of the sensor device. Depending on the material of the wave guide portion, this results in acoustic wavelengths of 200 - 9000 ⁇ m, typically 400 - 4000 ⁇ m.
- Typical in-plane dimensions of the wave guide portion are 600 - 1200 ⁇ m (longitudinal) x 400 - 900 ⁇ m (transverse) in one-dimensional modes of operation and 600 — 900 ⁇ m for both lateral directions in two-dimensional modes of operation.
- the thickness of the wave guide portion can be, for example 10 - 30 ⁇ m.
- the lateral dimensions of the wave guide portion are adjusted taking into account the used BAW wavelength and desired vibrational modes.
- the electro-mechanical conversion of energy can be carried out capacitively, as shown in Fig. 4.
- the transducer electrodes 410 are separated from the wave guide 406 by narrow gaps 408.
- the size of the gaps 408 is typically 0.7 - 1 ⁇ m, preferably 0.3 - 0.7 ⁇ m. Narrower gaps provides for better capacitive coupling of the transducers to the wave guide.
- Fig. 4 represents an open system, where the sample-receiving surface is directly accessible, as was also the case in the embodiment of Fig. 1.
- Fig. 4 illustrates also an embodiment, where the sample-receiving surface of the wave guide is coated with hydrophobic material 422 outside the actual sample-receiving zone 404.
- the electrodes 410 and/or the narrow gaps 408 are coated with hydrophobic material 422.
- the hydrophobic coatings 422 enable easy sample introduction using an injection tube 418. The sample spreads over the sample-receiving zone 404 but when close to the borders of the zone, the hydrophobic coating 422 prevents the sample from entering outside the sample-receiving zone, and ultimately into the capacitive gaps 408 or electrodes 410.
- the liquid sample can be directed to the sample-receiving area through narrow bores e.g.
- the sample-receiving zone typically the MSL on the zone, 404 can be made hydrophilic to achieve or to assist concentration of the sample on the desired measurement area.
- An additional buffer layer or layers 416 can be arranged on the resonator.
- a buffer layer is applied between the resonator and an MSL.
- the buffer layer is preferably made of an inert substance, such as gold.
- a suitable basis for the MSL can be formed. Also the total mass or resonance properties of the resonator can be affected by the buffer layer.
- the wave guide portion 406 can be separated (spaced) from the body 400 of the device by using the insulator layer of the SOI wafer.
- a support 424 is left in the centre of the wave guide 406.
- the support can be point-like or elongated in the direction perpendicular to the projection plane of Fig. 4.
- there are two or more supports 424 placed symmetrically with respect to the resonator 406, preferably at the node points of the acoustic waves or at points at a distance of ⁇ /4+N* ⁇ /2 from the ends of the wave guide, where N O, 1, 2, 3, ....
- the sample can be carried to the sensing surface 404 by a separate capillary pipe 418 or bore included in the package of the chip manufactured e.g. by hot-embossing, injection molding, alumina plate or LTCC technology.
- the end of the pipe 418 is attached close to (above) the sensing surface 404 so that the sample droplet can stay in touch with pipe while the lower part of the droplet is touching/spreading over the hydrophilic sensing sur- face.
- shallow cups or basins are etched on the resonator plate (especially on the sample-receiving zone) to ease liquid handling and to improve the alignment of the liquid sample with the mode structure of the resonator.
- This kind of local thinning of the plate can also be used to enhance the mass sensitivity of the sensor, while still providing the possibility to use structures thick enough to resist bending (induced e.g. by undesired capillary forces possibly occurring in packaged systems).
- the noise generated by the evaporation of small- volume liquid samples can be a problem.
- Such noise can be minimized/eliminated by careful design of the resonance mode, i.e. by selecting the lowest harmonic resonance mode that allows placing the edges of the droplet on/close to the nodes of the standing wave on the resonator.
- each transducer element can extend to the vicinity of two adjacent ends of the resonator.
- different two-dimensional modes can also be excited with a single transducer element, the modes depending on the crystal orientations and the lateral dimensions of the plate.
- Figs. 5, 8 and 9 illustrate embodiments, where the sample is introduced through the body 500, 800, 900 of the device, respectively.
- the embodiment shown in Figs. 5 and 6 in two different angles represents a 2D-BAW structure with square-extensional lateral vibration mode.
- the resonator 506, 606 is made on a silicon-on-insulator (SOI) wafer using standard processing methods [Mattilal, Kaaja- karil].
- SOI silicon-on-insulator
- the resonator 506, 606 is anchored to the body 500 at center. Additional or substitutive corner anchoring is also possible.
- the buried oxide (BOX) anchor 524 is ring-shaped (a torus) and accommodates the sample-receiving surface 504 at the center. The sensing surface is accessed from "backside" of the device via an opening 520 etched through the substrate 500.
- the ring-shaped oxide anchor 524 physically isolates the two sides of the SOI-wafer. This allows easy sample insertion since the liquid is separated from the open structures in device layer, especially the electromechanical coupling gaps and isolation trenches etc.
- the final packaged structure conveniently allows the sample insertion and electrical contacting from opposite sides of the component.
- the electrical contact pads are denoted with a reference numeral 534, the contacting feed-throughs, preferably also of silicon, being denoted with a numeral 532.
- the feed- throughs 532 can be isolated from the capping wafer 550 with isolators 530.
- the coupling to the laterally propagating sound waves is strong for the molecule specific layers exhibiting sufficient amount of stiffness. This is because the largest strain, i.e. relative dis- placement of the lattice planes, surrounds the centre. From another perspective, the resonator motion in absolute coordinates is smallest near the centre which prevents unwanted changes in the effective mass of the resonator due to the mass of the liquid sample.
- the molecular recognition taking place at the sample-receiving surface, preferably the mole- cule-specific layer, affects the sound propagation which is detected as a change in the resonance frequency.
- the ring-anchor diameter (analysis surface area) can be somewhat varied to meet the resolution or other requirements (e.g. sample size). However, increasing the anchor size will result in decrease of the resonator Q-value. If necessary, a higher-order mode, such as a "/1/4 — ⁇ — ⁇ /4" mode (see e.g. Fig. 10), which allows anchor positioning at the node points can be utilized. In addition to the square extensional mode, other modes of the square plate may also be utilized if anchor positioning closer to the node points is required (see e.g. Fig. 7).
- Fig. 7 an example of the total vibrations of a simulated mode is shown. From the figure it is seen that the illustrated mode exhibits very little motion on the five spot-like areas (merged with each other to form an x-shaped pattern in the figure due to the poor color scale resolution) which can be used as potential anchor positions (i.e. anchors attached to those positions do not generate significant losses to the mode).
- FIG. 13 - 16 More simulated oscillation mode structures are shown in Figs. 13 - 16.
- the amplitude of the vibrational movement of the resonator plate is illustrated by using shad- ing.
- the shades on the left of the shade bars shown represent low amplitudes and the shades on the right end of the bars represent higher amplitudes.
- the minimum and maximum values are indicated in the figures.
- Figs. 13a - 13c the total vibrations of three low modes (i.e., Lame, "Corner-Lame” and Square-Extensional modes) of a square-shaped resonator are shown. Although being highly two-dimensional due to the dimensions of the resonator, all the shown modes can be excited by actuation from one side of the resonator only. This illustrates the advantage of the use of longitudinal BAW modes, that the waves are easily reflected from the boundaries of the resonator, which provides for high flexibility in selecting the mode used. Of course, diverse modes can be excited by using a more complex excitation scheme (more electrodes, different dimensions, differently placed anchor parts). , ⁇
- Fig. 14 shows the total vibrations of a preferred mode excited to an elongated resonator.
- the surface-normal component of the vibration is very low on the whole area of the resonator.
- Figs. 15a and 15b show a total and surface-normal amplitudes, respectively, of another preferred mode structure of a resonator.
- the shown mode can be used for effectively analyzing the areas close to the centre of a sample droplet, as the lateral oscillation energy is high and surface-normal oscillation energy is low in a ring-shaped area in the vicinity of the centre of the resonator.
- all the movements are relatively low outside the ring-shaped area, where the boundary of the droplet is placed. This configuration enables the reduction of the noise generated by possible (undesired) variations in the size of the droplet.
- Figs. 16a and 16b show a total and surface-normal amplitudes, respectively, of another mode structure of a resonator.
- Fig. 8 illustrates an embodiment, where the sample is intro- swiped through the body 800, but still the front side of the device layer of the structure is used for analysis.
- the semiconductor body 800 and the resonator 806 are provided with openings for introduction of samples on the sample-receiving zone from the direction of the semiconductor body 800.
- the basic structure of the resonator is as described referring to Fig. 4, but a hole 820 etched through the substrate 800 now contin- ues through the whole structure.
- the liquid samples, as well as the solutions needed for the preparation of the molecule-specific coatings 804 of the sample-receiving zone, are dispensed in the hydrophilic (capillary) opening 820 from the substrate side.
- the opening 820 leads the liquid to the front side of the structure where the central area of the resonator 806 is made hydrophilic, while the rest of the surfaces are made hydrophobic. Both gravita- tional and capillary forces can be utilized for the transport of the liquid. If seen beneficial, additional under- or overpressure may also be applied, as well as protective wafer capping 850 on the device-layer side.
- the end of the hole 820 on the substrate side can even be plugged and the device-layer side hermetically capped (or vacuum encapsulated) after the preparation of the device and the molecule-specific membrane 804. The plug is broken while injecting the sample. If the interiors of the device are vacuum encapsulated, the prevailing underpressure helps to transport the sample onto the sample-receiving zone.
- the support 824 can be ring-shaped as described above. Appropriate hydrophilic or hydropho- 5 bic coatings can be arranged on the support and surrounding surfaces in each case for assisting transporting of the sample in contact with the reson
- Figs. 9 and 10 show yet another embodiment of the device.
- the device represents a one- dimensional wave version of the device shown in Fig. 6.
- the wave guide 906 acts as a ID-BAW resonator vibrating in a lateral length-extensional mode.
- the resonator 906 consists of two arm-plates 1072 (having a preferable length of ⁇ lA), connected to each other by a bridge-plate 1074 (preferably of ⁇ l2 (or n*i/2) in length) on which the molecule-specific coating 904 is attached with the required buffer layers 916 (e.g. gold).
- the sensing surface 904 on the backside of the device layer can be accessed from the backside via a hole (or holes) etched through the substrate.
- the two oxide ridges 924, 1024 at the node points protect the open structures of the device-layer side only in one dimension.
- Hydrophobic surface treatments can be used to concentrate the liquid to the hydrophilic sensing surface on the centre of the bridge-plate also in the other lateral direction. Similar hydrophobic/hydrophilic treatments can also be applied if the open front side of the resonator is used for sensing in either ID- or 2D-B AW resonators, as in previous embodiments.
- the molecule-specific membrane, possible buffer layers underneath (e.g. gold) and possible surface treatments to make surfaces hydrophilic/hydrophobic can be conveniently deposited through the hole in the substrate.
- the substrate acts as a self-aligned mask. In the case of front side detection, additional masks are needed for the surface treatments.
- the senor can be designed to be driven in a ID or 2D mode.
- 2D operation provides several advantages that result in better signal quality, that is, resolution of experiments.
- the wave guide can thus be kept thin for improved sensitivity.
- Second, 2D arrangement provides more possibilities for selecting the operational wave mode. By a carefully selected mode, the normal-to-surface motion of the crystal can be reduced. This is because when using a mode where while the resonator is expanding in one cartesian direction, it contracts in the other, the displacements in the third cartesian direc- tion can be minimized.
- the quality factor Q of an unloaded resonator can be as good as 80 000 - 200 000, preferably at least 120 000 and even higher, when operating at a frequency of 10 MHz in vacuum.
- the area of the sample-receiving zone can be 5 - 80 %, preferably 40 - 70 % of the whole area of the sample-receiving surface of the wave guide.
- a more important factor in the designing of the resonators and experiments is how the sample is located in relation to the vibrational mode.
- capacitive electro-mechanical conversion of energy is utilized.
- the need of piezoactive materials is avoided.
- the embodiments described above also provide for convenient protection of the capacitive gaps, whereby the reliability of the measurements is increased.
- the chips can be easily manufactured without complex starting materials or production phases using fabrication methods known per se.
- Capacitive actuation also provides for more flexibility in the designing of excitation and readout electronics.
- the use of piezoactive transducers is justifiable.
- the critical parts of the sensor element can be hermetically isolated or vacuum packed. That is, the space surrounding the sample-receiving zone can be kept sealed or at underpressure until the device is used for the first time. At the time of usage, the seal (typically a distinct part of the casing of the device or a micromechanical "plug" in the device layer or the body of the sensor) is broken or removed and the sample introduced.
- the seal typically a distinct part of the casing of the device or a micromechanical "plug" in the device layer or the body of the sensor
- the cleanness of the sample-receiving zone can be secured and/or the introduction of the sample through the micromechanical structures can be assisted.
- the input electronics of the sensor element can comprise integrated means for performing the electrical actuation, whether piezoelectric or capacitive.
- the amplitude of the voltage over the gap between the input electrode and the wave guide can be, for example, 10 - 100 V.
- the output electronics of the sensor may comprise an integrated preamplifier for detecting the resonance.
- Fig. 3 shows a sensor array with six sensors as an example. Electrode l ⁇ ⁇ n 320 is used to drive all sensors 301 - 306 and electrode U 3 J n 330 is used to monitor the voltage across the sensors input terminals. A feedback electronic is used to keep the input voltage constant.
- the four terminal electrode arrangement shown in Fig. 3 enables one to use capacitive contacts between the sensor elements 301 - 306 and readout electronics.
- the other possibility is to measure currents from the sensors using only one (or two) electrode(s) but in that case the mechanical resonant frequencies have to be made different in order to separate them in the frequency space. It should be noticed that if set- ting the resonators in parallel or in series to simplify the readout electronics impairs the resolution and should not be applied if not necessarily needed.
- capacitive actuation DC bias should be avoided and replaced by AC bias, if possible, in order to avoid instabilities related to the surface phenomena [Karkkainenl].
- Fig. 11 illustrates a measurement configuration based on two oscillators for convenient detection of the sample-induced change in the resonator eigenfrequency.
- a molecule-specific sensor and a reference sensor are coupled in parallel and contacted to comparator circuitry 1188, 1190.
- the reference resonator is otherwise similar to the molecule-specific resonator, but has a non-specific sample-receiving area.
- Feedback circuitry 1180 is used to create the sustained oscillatory operation.
- the frequency differ- ence between the two oscillators is resolved e.g. by inserting the output signals to a mixer 1188 followed by a low-pass filter 1190.
- the eigenfrequency of silicon micromechanical resonators exhibits a large temperature dependence (typically ⁇ -30 ppm/K). Therefore, liquid sample insertion is expected to cause a significant temperature-change related frequency shift.
- the two resonators fabricated on the same chip are expected to rapidly gain thermal equilibrium with each other. By monitoring the frequency difference between the molecule-specific and reference resonators the temperature effect is canceled to the first degree.
- a multiple of resonators can be utilized for improved analysis resolution.
- Fig. 12 shows an example of such an arrangement having six sensor elements 1201 - 1206 illustrated.
- half of the sensor elements are reference sensors and half of the sensors are prepared for molecule specificity using a molecule-specific layer.
- the sensors pairs can be coupled as described above or by a centralized comparator 1260.
- all of the sensors are molecule-specific.
- Each of the sensors or sensor pairs can be driven at the same frequency or at different frequencies.
- a multiple-frequency measurement can provide information on the sample not available at a single frequency.
- Vikholm 3 I. Vikholm-Lundin, Immunosensing based on site-directed immobilisation of antibody fragments and polymer that reduce nonspecific binding,
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CN2006800248689A CN101218503B (en) | 2005-07-08 | 2006-07-04 | Micromechanical sensor, sensor array and method |
US11/988,417 US8136403B2 (en) | 2005-07-08 | 2006-07-04 | Micromechanical sensor, sensor array and method |
GB0801930A GB2442415B (en) | 2005-07-08 | 2006-07-04 | Micromechanical sensor, sensor array and method |
HK08110342.6A HK1118906A1 (en) | 2005-07-08 | 2008-09-18 | Micromechanical sensor, sensor array and method |
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CN (1) | CN101218503B (en) |
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FI20050739A0 (en) | 2005-07-08 |
GB2442415B (en) | 2009-05-27 |
US8136403B2 (en) | 2012-03-20 |
US20090277271A1 (en) | 2009-11-12 |
FI118829B (en) | 2008-03-31 |
GB0801930D0 (en) | 2008-03-12 |
CN101218503A (en) | 2008-07-09 |
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CN101218503B (en) | 2012-01-04 |
FI20050739A (en) | 2007-01-09 |
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