WO2007003675A3 - Modele experimental de neuro-inflammation, procede d'obtention et applications - Google Patents
Modele experimental de neuro-inflammation, procede d'obtention et applications Download PDFInfo
- Publication number
- WO2007003675A3 WO2007003675A3 PCT/ES2006/000387 ES2006000387W WO2007003675A3 WO 2007003675 A3 WO2007003675 A3 WO 2007003675A3 ES 2006000387 W ES2006000387 W ES 2006000387W WO 2007003675 A3 WO2007003675 A3 WO 2007003675A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- experimental
- neuroinflammation
- model
- applications
- obtaining same
- Prior art date
Links
- 208000036110 Neuroinflammatory disease Diseases 0.000 title abstract 3
- 230000003959 neuroinflammation Effects 0.000 title abstract 3
- 102000004631 Calcineurin Human genes 0.000 abstract 2
- 108010042955 Calcineurin Proteins 0.000 abstract 2
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 2
- 102000000584 Calmodulin Human genes 0.000 abstract 1
- 108010041952 Calmodulin Proteins 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 238000010171 animal model Methods 0.000 abstract 1
- 210000001130 astrocyte Anatomy 0.000 abstract 1
- 230000003140 astrocytic effect Effects 0.000 abstract 1
- 230000001908 autoinhibitory effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 208000011851 neurological alteration Diseases 0.000 abstract 1
- 230000016273 neuron death Effects 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0368—Animal model for inflammation
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Pathology (AREA)
- Organic Chemistry (AREA)
- Environmental Sciences (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
Abstract
Ce modèle expérimental de neuro-inflammation est un animal transgénique caractérisé par ce qu'il exprime, exclusivement en astrocytes, une forme mutée de calcinerine exempte de la totalité ou d'une partie du domaine d'union de calmoduline et/ou du domaine auto-inhibiteur. Ce modèle animal peut servir à étudier et évaluer la progression des maladies neurodégénératives accompagnées d'une neuro-inflammation et d'altérations neurologiques pathologiques occasionnées par l'inflammation provoquant la mort neuronale et pour identifier des composés anti-inflammatoires, dont l'effet anti-inflammatoire est dû à une stimulation de la calcinerine astrocytaire.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200501650A ES2289877B1 (es) | 2005-07-06 | 2005-07-06 | Modelo experimental de neuroinflamacion, procedimiento de obtencion y sus aplicaciones. |
ESP200501650 | 2005-07-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007003675A2 WO2007003675A2 (fr) | 2007-01-11 |
WO2007003675A3 true WO2007003675A3 (fr) | 2007-04-26 |
Family
ID=37604829
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/ES2006/000387 WO2007003675A2 (fr) | 2005-07-06 | 2006-07-05 | Modele experimental de neuro-inflammation, procede d'obtention et applications |
Country Status (2)
Country | Link |
---|---|
ES (1) | ES2289877B1 (fr) |
WO (1) | WO2007003675A2 (fr) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996035126A1 (fr) * | 1995-05-03 | 1996-11-07 | President And Fellows Of Harvard College | Evaluation du role de la calcineurine en matiere d'immunosuppression et de neurotoxicite |
WO2000009662A1 (fr) * | 1998-08-17 | 2000-02-24 | The Trustees Of Columbia University In The City Of New York | Animal transgenique et ses utilisations pour l'identifier des composes utilises pour ameliorer la memoire a long terme |
WO2003012093A2 (fr) * | 2001-07-31 | 2003-02-13 | Genopia Biomedical Gmbh | Regulateur de la calcineurine |
-
2005
- 2005-07-06 ES ES200501650A patent/ES2289877B1/es not_active Expired - Fee Related
-
2006
- 2006-07-05 WO PCT/ES2006/000387 patent/WO2007003675A2/fr active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996035126A1 (fr) * | 1995-05-03 | 1996-11-07 | President And Fellows Of Harvard College | Evaluation du role de la calcineurine en matiere d'immunosuppression et de neurotoxicite |
WO2000009662A1 (fr) * | 1998-08-17 | 2000-02-24 | The Trustees Of Columbia University In The City Of New York | Animal transgenique et ses utilisations pour l'identifier des composes utilises pour ameliorer la memoire a long terme |
WO2003012093A2 (fr) * | 2001-07-31 | 2003-02-13 | Genopia Biomedical Gmbh | Regulateur de la calcineurine |
Non-Patent Citations (6)
Title |
---|
CONBOY I.M. ET AL.: "calcineurin and vacuolar-type H+-ATPase modulate macrophage effector functions", PROC. ACAD. SCI. U.S.A., vol. 96, no. 11, 25 May 1999 (1999-05-25), pages 6324 - 6329, XP003010493 * |
KAMINSKA B. ET AL.: "Molecular mechanisms of neuroprotective action of immunosuppressants-facts and hypotheses", J. CELL MOL. MED., vol. 8, no. 1, 2004, pages 45 - 58, XP003010495 * |
NORRIS C.M. ET AL.: "Calcineurin triggers reactive/inflammatory processes astrocytes and is upregulated in aging and Alzheimer's models", JOURNAL OF NEUROSCIENCE, vol. 25, no. 18, 4 May 2005 (2005-05-04), pages 4649 - 4658, XP003010491 * |
PONS S. ET AL.: "Insulin-like growth factor-I stimulates dephosphorylation of ikappa B through the serine phosphatase calcineurin (protein phosphatase 2B)", J. BIOL. CHEM., vol. 275, no. 49, 8 December 2000 (2000-12-08), pages 38620 - 38625, XP003010494 * |
SAYEN M.R. ET AL.: "Calcineurin transgenic mice have mitochondrical dysfunction and elevated superoxide production", AM. J. PHYSIOL. CELL PHYSIOL., vol. 284, no. 2, February 2003 (2003-02-01), pages C562 - C570, XP003010492 * |
WINDER D.G. ET AL.: "Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin", CELL, vol. 92, no. 1, 9 January 1998 (1998-01-09), pages 25 - 37, XP002916706 * |
Also Published As
Publication number | Publication date |
---|---|
ES2289877B1 (es) | 2008-12-01 |
WO2007003675A2 (fr) | 2007-01-11 |
ES2289877A1 (es) | 2008-02-01 |
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