WO2007002912A3 - Anti-proliferative compounds, compositions, and methods of use thereof - Google Patents

Anti-proliferative compounds, compositions, and methods of use thereof Download PDF

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Publication number
WO2007002912A3
WO2007002912A3 PCT/US2006/025726 US2006025726W WO2007002912A3 WO 2007002912 A3 WO2007002912 A3 WO 2007002912A3 US 2006025726 W US2006025726 W US 2006025726W WO 2007002912 A3 WO2007002912 A3 WO 2007002912A3
Authority
WO
WIPO (PCT)
Prior art keywords
carbon atoms
independently
groups
substituted
compositions
Prior art date
Application number
PCT/US2006/025726
Other languages
French (fr)
Other versions
WO2007002912A2 (en
Inventor
Xiaoqin Cheng
Gary P Cook
Manoj C Desai
Edward Doerffler
Gong-Xin He
Choung U Kim
William A Lee
John C Rohloff
Jianying Wang
Zheng-Yu Yang
Original Assignee
Gilead Sciences Inc
Xiaoqin Cheng
Gary P Cook
Manoj C Desai
Edward Doerffler
Gong-Xin He
Choung U Kim
William A Lee
John C Rohloff
Jianying Wang
Zheng-Yu Yang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/170,247 external-priority patent/US20060030545A1/en
Application filed by Gilead Sciences Inc, Xiaoqin Cheng, Gary P Cook, Manoj C Desai, Edward Doerffler, Gong-Xin He, Choung U Kim, William A Lee, John C Rohloff, Jianying Wang, Zheng-Yu Yang filed Critical Gilead Sciences Inc
Publication of WO2007002912A2 publication Critical patent/WO2007002912A2/en
Publication of WO2007002912A3 publication Critical patent/WO2007002912A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Compounds and compositions of Formula I are described, useful as anti-proliferative agents, and in particular anti-HPV, wherein: Y1A and Y1B are independently Y1; RX1 is RX; RX2 is alkenyl of 2 to 18 carbon atoms or alkynyl of 2 to 18 carbon atoms; Y1 is = O, -O(RX), =S, -N(RX), -N(O)(RX), -N(ORX), -N(O)(ORX), or -N(N(RX)(RX)); RX is independently R1, R2, R4, W3, or a protecting group; R1 is independently -H or alkyl of 1 to 18 carbon atoms; R2 is independently R3 or R4 wherein each R4 is independently substituted with 0 to 3 R3 groups or taken together at a carbon atom, two R2 groups form a ring of 3 to 8 carbons and the ring may be substituted with 0 to 3 R3 groups; R3 is R3a, R3b, R3c or R3d, provided that when R3 is bound to a heteroatom, then R3 is R3c or R3d; R3a is -H, -F, -Cl, -Br, -I, -CF3, -CN, N3, -NO2 or -OR4; R3b is = O, -O(R4), =S, -N(R4), -N(O)(R4), -N(OR4), -N(O)(OR4), or -N(N(R4)(R4)); 3c is -R4, -N(R4)(R4), -SR4, -S(O)R4, -S(O)2R4, -S(O)(OR4), -S(O)2(OR4), -OC(R3b)R4, -OC(R3b)OR4, -OC(R3b)(N(R4)(R4)), -SC(R3b)R4, -SC(R3b)OR4, -SC(R3b)(N(R4)(R4)), -N(R4)C(R3b)R4, -N(R4)C(R3b)OR4, -N(R4)C(R3b)(N(R4)(R4)), W3 or -R5W3 ; R3d is -C(R3b)R4, -C(R3b)OR4, -C(R3b)W3, -C(R3b)OW3 or -C(R3b)(N(R4)(R4)); R4 is -H, or an alkyl of 1 to 18 carbon atoms, alkenyl of 2 to 18 carbon atoms, or alkynyl of 2 to 18 carbon atoms; R5 is alkylene of 1 to 18 carbon atoms, alkenylene of 2 to 18 carbon atoms, or alkynylene of 2 to 18 carbon atoms; W3 is W4 or W5; W4 is R6, -C(R3b)R6, -C(R3b)W5, -SOM2R6, or -SOM2W5, wherein R6 is R4 wherein each R4 is substituted with O to 3 R3 groups; W5 is carbocycle or heterocycle wherein W5 is independently substituted with O to 3 R2 groups; and M2 is 0, 1 or 2; or pharmaceutically acceptable salts thereof.
PCT/US2006/025726 2005-06-29 2006-06-29 Anti-proliferative compounds, compositions, and methods of use thereof WO2007002912A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/170,247 2005-06-29
US11/170,247 US20060030545A1 (en) 2003-12-30 2005-06-29 Anti-proliferative compounds, compositions, and methods of use thereof

Publications (2)

Publication Number Publication Date
WO2007002912A2 WO2007002912A2 (en) 2007-01-04
WO2007002912A3 true WO2007002912A3 (en) 2007-06-28

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/025726 WO2007002912A2 (en) 2005-06-29 2006-06-29 Anti-proliferative compounds, compositions, and methods of use thereof

Country Status (1)

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WO (1) WO2007002912A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI444384B (en) 2008-02-20 2014-07-11 Gilead Sciences Inc Nucleotide analogues and their use in the treatment of malignancies
ES2874774T3 (en) 2011-12-22 2021-11-05 Geron Corp Guanine Analogs as Telomerase Substrates and Telomere Length Affects
CN103665043B (en) 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 A kind of tenofovir prodrug and its application in medicine
HRP20220651T1 (en) 2014-09-15 2022-08-19 The Regents Of The University Of California Nucleotide analogs
EP3875462A1 (en) 2015-09-15 2021-09-08 The Regents of The University of California Nucleotide analogs
US10745428B2 (en) 2015-12-10 2020-08-18 Idenix Pharmaceuticals Llc Antiviral phosphodiamide prodrugs of tenofovir
WO2017106069A1 (en) 2015-12-15 2017-06-22 Merck Sharp & Dohme Corp. Antiviral oxime phosphoramide compounds
US10736908B2 (en) 2016-10-26 2020-08-11 Merck Sharp & Dohme Corp. Antiviral aryl-amide phosphodiamide compounds
JP2020504734A (en) 2016-12-22 2020-02-13 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Antiviral benzyl-amine phosphodiamide compounds
AU2017379850B2 (en) 2016-12-22 2022-03-24 Msd International Gmbh Antiviral aliphatic ester prodrugs of tenofovir
EP3823629A4 (en) 2018-07-19 2022-05-04 Merck Sharp & Dohme Corp. Phosphinic amide prodrugs of tenofovir

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005066189A1 (en) * 2003-12-30 2005-07-21 Gilead Sciences, Inc. Phosphonates, monophosphonamidates, bisphosphonamidates for the treatment of viral diseases

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005066189A1 (en) * 2003-12-30 2005-07-21 Gilead Sciences, Inc. Phosphonates, monophosphonamidates, bisphosphonamidates for the treatment of viral diseases
US20050222090A1 (en) * 2003-12-30 2005-10-06 Gilead Sciences, Inc. Anti-proliferative compounds, compositions, and methods of use thereof
US20060046981A1 (en) * 2003-12-30 2006-03-02 Gilead Sciences, Inc. Anti-nonmelanoma carcinoma compounds, compositions, and methods of use thereof

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
HOLY, ANTONIN ET AL: "Synthesis and cytostatic activity of N-[2-(phosphonomethoxy)alkyl] derivatives of N6-substituted adenines, 2,6-diaminopurines and related compounds", COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS , 66(10), 1545-1592 CODEN: CCCCAK; ISSN: 0010-0765, 2001, XP009054316 *
KEITH, KATHY A. ET AL: "Evaluation of nucleoside phosphonates and their analogs and prodrugs for inhibition of orthopoxvirus replication", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY , 47(7), 2193-2198 CODEN: AMACCQ; ISSN: 0066-4804, 2003, XP002327373 *
SNOECK, R. ET AL: "Antivaccinia activities of acyclic nucleoside phosphonate derivatives in epithelial cells and organotypic cultures", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY , 46(11), 3356-3361 CODEN: AMACCQ; ISSN: 0066-4804, 2002, XP002327372 *
VALERIANOVA M ET AL: "ANTITUMOUR ACTIVITY OF N6-SUBSTITUTED PMEDAP DERIVATIVES AGAINST T-CELL LYMPHOMA", ANTICANCER RESEARCH, HELENIC ANTICANCER INSTITUTE, ATHENS,, GR, vol. 21, no. 3B, May 2001 (2001-05-01), pages 2057 - 2064, XP009071015, ISSN: 0250-7005 *
VALERIANOVA M ET AL: "PMEDAP AND ITS N6-SUBSTITUTED DERIVATIVES: GENOTOXIC EFFECT AND APOPTOSIS IN IN VITRO CONDITIONS", ANTICANCER RESEARCH, HELENIC ANTICANCER INSTITUTE, ATHENS,, GR, vol. 23, no. 6C, November 2003 (2003-11-01), pages 4933 - 4940, XP009071017, ISSN: 0250-7005 *
ZIDEK, ZDENEK ET AL: "Immunobiological activity of N-[2-(phosphonomethoxy)alkyl] derivatives of N6-substituted adenines, and 2,6-diaminopurines", EUROPEAN JOURNAL OF PHARMACOLOGY , 475(1-3), 149-159 CODEN: EJPHAZ; ISSN: 0014-2999, 2003, XP002405408 *

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Publication number Publication date
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