WO2007001466A3 - Peptidomimetic somatostatin receptor subtype 2 ligands and pet imaging agents - Google Patents

Peptidomimetic somatostatin receptor subtype 2 ligands and pet imaging agents Download PDF

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Publication number
WO2007001466A3
WO2007001466A3 PCT/US2005/043983 US2005043983W WO2007001466A3 WO 2007001466 A3 WO2007001466 A3 WO 2007001466A3 US 2005043983 W US2005043983 W US 2005043983W WO 2007001466 A3 WO2007001466 A3 WO 2007001466A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptidomimetic
ligands
imaging agents
receptor subtype
pet imaging
Prior art date
Application number
PCT/US2005/043983
Other languages
French (fr)
Other versions
WO2007001466A2 (en
Inventor
Seok Rye Choi
Guoxia Han
Original Assignee
Kung Hank F
Seok Rye Choi
Guoxia Han
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kung Hank F, Seok Rye Choi, Guoxia Han filed Critical Kung Hank F
Publication of WO2007001466A2 publication Critical patent/WO2007001466A2/en
Publication of WO2007001466A3 publication Critical patent/WO2007001466A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention is directed to compounds useful as peptidomimetics for binding and/or imaging somatostatin subtype 2 receptors, and compositions comprising the compounds. The present invention is also directed to methods of preparing radiolabeled peptidomimetic compounds and methods of imaging receptors using the compounds. The present invention is also directed to a method of preparing (2R, 3S)-β-Me-DBta.
PCT/US2005/043983 2005-06-14 2005-12-06 Peptidomimetic somatostatin receptor subtype 2 ligands and pet imaging agents WO2007001466A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69009305P 2005-06-14 2005-06-14
US60/690,093 2005-06-14

Publications (2)

Publication Number Publication Date
WO2007001466A2 WO2007001466A2 (en) 2007-01-04
WO2007001466A3 true WO2007001466A3 (en) 2007-06-21

Family

ID=37595617

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/043983 WO2007001466A2 (en) 2005-06-14 2005-12-06 Peptidomimetic somatostatin receptor subtype 2 ligands and pet imaging agents

Country Status (1)

Country Link
WO (1) WO2007001466A2 (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8685752B2 (en) 2006-11-03 2014-04-01 Purdue Research Foundation Ex vivo flow cytometry method and device
US8795633B2 (en) 2005-09-23 2014-08-05 Purdue Research Foundation Multiphoton in vivo flow cytometry method and device
US8808998B2 (en) 2003-05-30 2014-08-19 Purdue Research Foundation Diagnostic method for atherosclerosis
US8858914B2 (en) 2002-02-07 2014-10-14 Endocyte, Inc. Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology
US8865128B2 (en) 2002-02-07 2014-10-21 Endocyte, Inc. Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology
US8916167B2 (en) 2001-05-02 2014-12-23 Purdue Research Foundation Treatment and diagnosis of macrophage mediated disease
US8961926B2 (en) 2007-05-25 2015-02-24 Purdue Research Foundation Method of imaging localized infections
US9180215B2 (en) 2007-02-07 2015-11-10 Purdue Research Foundation Positron emission tomography imaging method

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1904183B1 (en) 2005-07-05 2014-10-15 Purdue Research Foundation Pharmaceutical composition for the treatment of osteoarthritis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YANG L. ET AL.: "Synthesis and Biological Activities of Potent Peptidometics Selective for Somatostatin Receptor Subtype 2", PROCEEDINGS OF NATIONAL ACADEMY OF SCIENCES, vol. 95, September 1998 (1998-09-01), pages 10836 - 10841, XP002916393 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8916167B2 (en) 2001-05-02 2014-12-23 Purdue Research Foundation Treatment and diagnosis of macrophage mediated disease
US8858914B2 (en) 2002-02-07 2014-10-14 Endocyte, Inc. Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology
US8865128B2 (en) 2002-02-07 2014-10-21 Endocyte, Inc. Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology
US8808998B2 (en) 2003-05-30 2014-08-19 Purdue Research Foundation Diagnostic method for atherosclerosis
US8795633B2 (en) 2005-09-23 2014-08-05 Purdue Research Foundation Multiphoton in vivo flow cytometry method and device
US8685752B2 (en) 2006-11-03 2014-04-01 Purdue Research Foundation Ex vivo flow cytometry method and device
US9279813B2 (en) 2006-11-03 2016-03-08 Purdue Research Foundation Ex vivo flow cytometry method and device
US9180215B2 (en) 2007-02-07 2015-11-10 Purdue Research Foundation Positron emission tomography imaging method
US8961926B2 (en) 2007-05-25 2015-02-24 Purdue Research Foundation Method of imaging localized infections

Also Published As

Publication number Publication date
WO2007001466A2 (en) 2007-01-04

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