WO2007000043A3 - Pyrazolo[3,4-b]pyridin-2-yl]-benzoic acid derivatives as hiv integrase inhibitors - Google Patents

Pyrazolo[3,4-b]pyridin-2-yl]-benzoic acid derivatives as hiv integrase inhibitors Download PDF

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Publication number
WO2007000043A3
WO2007000043A3 PCT/CA2006/001049 CA2006001049W WO2007000043A3 WO 2007000043 A3 WO2007000043 A3 WO 2007000043A3 CA 2006001049 W CA2006001049 W CA 2006001049W WO 2007000043 A3 WO2007000043 A3 WO 2007000043A3
Authority
WO
WIPO (PCT)
Prior art keywords
pyrazolo
pyridin
benzoic acid
acid derivatives
hiv integrase
Prior art date
Application number
PCT/CA2006/001049
Other languages
French (fr)
Other versions
WO2007000043A2 (en
Inventor
Brent Richard Stranix
Dominik Herbart
Valerie Perron
Original Assignee
Ambrilia Biopharma Inc
Brent Richard Stranix
Dominik Herbart
Valerie Perron
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ambrilia Biopharma Inc, Brent Richard Stranix, Dominik Herbart, Valerie Perron filed Critical Ambrilia Biopharma Inc
Priority to JP2008518578A priority Critical patent/JP2008546813A/en
Priority to EP06790527A priority patent/EP1906958A4/en
Priority to AU2006264170A priority patent/AU2006264170A1/en
Priority to CA002612300A priority patent/CA2612300A1/en
Publication of WO2007000043A2 publication Critical patent/WO2007000043A2/en
Publication of WO2007000043A3 publication Critical patent/WO2007000043A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The present invention provides compounds of formula (I) wherein Cx represents -CHO, -CH=N-OR3, -CH=N-NR3R4, -CH=N-R5 or -CH(OR3)2; m and n can be present up to four times and the other R radicals can vary from a hydrogen atom to different alkyl groups, halogen, rings or more. These compounds are used in pharmaceutical compositions for the treatment or prevention of AIDS or HIV infection, or for reducing HIV replication.
PCT/CA2006/001049 2005-06-27 2006-06-27 Pyrazolo[3,4-b]pyridin-2-yl]-benzoic acid derivatives as hiv integrase inhibitors WO2007000043A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2008518578A JP2008546813A (en) 2005-06-27 2006-06-27 [Pyrazolo [3,4-B] pyridin-2-yl] -benzoic acid derivatives as HIV integrase inhibitors
EP06790527A EP1906958A4 (en) 2005-06-27 2006-06-27 Pyrazolo[3,4-b]pyridin-2-yl]-benzoic acid derivatives as hiv integrase inhibitors
AU2006264170A AU2006264170A1 (en) 2005-06-27 2006-06-27 Pyrazolo[3,4-b]pyridin-2-yl)-benzoic acid derivatives as HIV integrase inhibitors
CA002612300A CA2612300A1 (en) 2005-06-27 2006-06-27 Pyrazolo[3,4-b]pyridin-2-yl]-benzoic acid derivatives as hiv integrase inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69383305P 2005-06-27 2005-06-27
US60/693,833 2005-06-27

Publications (2)

Publication Number Publication Date
WO2007000043A2 WO2007000043A2 (en) 2007-01-04
WO2007000043A3 true WO2007000043A3 (en) 2007-11-15

Family

ID=37595485

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2006/001049 WO2007000043A2 (en) 2005-06-27 2006-06-27 Pyrazolo[3,4-b]pyridin-2-yl]-benzoic acid derivatives as hiv integrase inhibitors

Country Status (6)

Country Link
EP (1) EP1906958A4 (en)
JP (1) JP2008546813A (en)
CN (1) CN101243080A (en)
AU (1) AU2006264170A1 (en)
CA (1) CA2612300A1 (en)
WO (1) WO2007000043A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2220084B1 (en) 2007-11-16 2014-02-19 Gilead Sciences, Inc. Inhibitors of human immunodeficiency virus replication
WO2017222921A1 (en) * 2016-06-22 2017-12-28 Xavier University Of Louisiana 2-hydroxyisophthalic acid and its derivatives: methods of making and applications

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2468927A1 (en) * 2001-12-04 2003-06-12 F. Hoffmann-La Roche Ag Ring fused pyrazole derivatives
CA2511340A1 (en) * 2002-12-23 2004-07-08 Glaxo Group Limited Pyrazolo[3,4-b]pyridine compounds, and their use as phosphodiesterase inhibitors
US20040167121A1 (en) * 2002-10-25 2004-08-26 Alex Aronov Indazolinone compositions useful as kinase inhibitors
CA2515197A1 (en) * 2003-02-27 2004-09-10 J. Uriach Y Compania S.A. Pyrazolopyridine derivates

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6825201B2 (en) * 2001-04-25 2004-11-30 Bristol-Myers Squibb Company Indole, azaindole and related heterocyclic amidopiperazine derivatives

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2468927A1 (en) * 2001-12-04 2003-06-12 F. Hoffmann-La Roche Ag Ring fused pyrazole derivatives
US20040167121A1 (en) * 2002-10-25 2004-08-26 Alex Aronov Indazolinone compositions useful as kinase inhibitors
CA2511340A1 (en) * 2002-12-23 2004-07-08 Glaxo Group Limited Pyrazolo[3,4-b]pyridine compounds, and their use as phosphodiesterase inhibitors
CA2515197A1 (en) * 2003-02-27 2004-09-10 J. Uriach Y Compania S.A. Pyrazolopyridine derivates

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1906958A4 *

Also Published As

Publication number Publication date
EP1906958A2 (en) 2008-04-09
JP2008546813A (en) 2008-12-25
EP1906958A4 (en) 2010-12-22
CA2612300A1 (en) 2007-01-04
CN101243080A (en) 2008-08-13
AU2006264170A1 (en) 2007-01-04
WO2007000043A2 (en) 2007-01-04

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