WO2006136170A3 - Disease risk estimating method using sequence polymorphisms in a specific region of chromosome 19 - Google Patents

Disease risk estimating method using sequence polymorphisms in a specific region of chromosome 19 Download PDF

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Publication number
WO2006136170A3
WO2006136170A3 PCT/DK2006/000367 DK2006000367W WO2006136170A3 WO 2006136170 A3 WO2006136170 A3 WO 2006136170A3 DK 2006000367 W DK2006000367 W DK 2006000367W WO 2006136170 A3 WO2006136170 A3 WO 2006136170A3
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WO
WIPO (PCT)
Prior art keywords
cancer
chromosome
increased risk
specific region
disease risk
Prior art date
Application number
PCT/DK2006/000367
Other languages
French (fr)
Other versions
WO2006136170A2 (en
Inventor
Bjoern Andersen Nexoe
Ulla Birgitte Vogel
Anders Boerglum
Original Assignee
Univ Aarhus
Det Nationale Forskningsct For
Bjoern Andersen Nexoe
Ulla Birgitte Vogel
Anders Boerglum
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/DK2005/000529 external-priority patent/WO2006018023A2/en
Application filed by Univ Aarhus, Det Nationale Forskningsct For, Bjoern Andersen Nexoe, Ulla Birgitte Vogel, Anders Boerglum filed Critical Univ Aarhus
Publication of WO2006136170A2 publication Critical patent/WO2006136170A2/en
Publication of WO2006136170A3 publication Critical patent/WO2006136170A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention provides methods and compositions for identifying human subjects with an increased risk of having or developing cancer. In particular, this invention relates to the identification and characterization of polymorphisms in the human chromosome 19q, the region r located approximately 19q 13.2-3 correlated with increased risk of developing cancer and the responsiveness of a subject to various treatments for cancer. An allele in the r region can be identified as correlated with an increased risk of developing cancer, the prognosis of developed cancer, and responsiveness to cancer treatment, on the basis of statistical analyses of the incidence of a particular allele in individuals diagnosed with cancer. The invention further relates to probes and kits comprising the probes useful in the diagnostic.
PCT/DK2006/000367 2005-06-22 2006-06-22 Disease risk estimating method using sequence polymorphisms in a specific region of chromosome 19 WO2006136170A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DKPA200500918 2005-06-22
DKPA200500918 2005-06-22
PCT/DK2005/000529 WO2006018023A2 (en) 2004-08-18 2005-08-17 Disease risk estimating method using sequence polymorphisms in a specific region of chromosome 19
DKPCT/DK2005/000529 2005-08-17
DKPA200600187 2006-02-09
DKPA200600187 2006-02-09

Publications (2)

Publication Number Publication Date
WO2006136170A2 WO2006136170A2 (en) 2006-12-28
WO2006136170A3 true WO2006136170A3 (en) 2007-06-28

Family

ID=37103306

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2006/000367 WO2006136170A2 (en) 2005-06-22 2006-06-22 Disease risk estimating method using sequence polymorphisms in a specific region of chromosome 19

Country Status (1)

Country Link
WO (1) WO2006136170A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120122698A1 (en) * 2008-07-07 2012-05-17 Decode Genetics Ehf. Genetic Variants Predictive of Cancer Risk in Humans
GB2466025A (en) * 2008-12-08 2010-06-09 Univ Francois Rabelais De Tour C3/ITGAM polymorphisms and cancer prognosis
WO2016119191A1 (en) * 2015-01-30 2016-08-04 Bgi Shenzhen Biomarkers for colorectal cancer related diseases

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004003229A2 (en) * 2002-06-27 2004-01-08 Aarhus Universitet Disease risk estimating method using sequence polymorphisms in a specific region of chromosome 19
WO2006018023A2 (en) * 2004-08-18 2006-02-23 Aarhus Universitet Disease risk estimating method using sequence polymorphisms in a specific region of chromosome 19

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004003229A2 (en) * 2002-06-27 2004-01-08 Aarhus Universitet Disease risk estimating method using sequence polymorphisms in a specific region of chromosome 19
WO2006018023A2 (en) * 2004-08-18 2006-02-23 Aarhus Universitet Disease risk estimating method using sequence polymorphisms in a specific region of chromosome 19

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHEN PENGCHIN ET AL: "Association of an ERCC1 polymorphism with adult-onset glioma", CANCER EPIDEMIOLOGY BIOMARKERS AND PREVENTION, vol. 9, no. 8, August 2000 (2000-08-01), pages 843 - 847, XP002261355, ISSN: 1055-9965 *
NEXO BJORN A ET AL: "A specific haplotype of single nucleotide polymorphisms on chromosome 19q13.2-3 encompassing the gene RAI is indicative of post-menopausal breast cancer before age 55.", CARCINOGENESIS (OXFORD), vol. 24, no. 5, May 2003 (2003-05-01), pages 899 - 904, XP002261349, ISSN: 0143-3334 *
ROCKENBAUER ESZTER ET AL: "Association of chromosome 19q13.2-3 haplotypes with basal cell carcinoma: Tentative delineation of an involved region using data for single nucleotide polymorphisms in two cohorts", CARCINOGENESIS (OXFORD), vol. 23, no. 7, July 2002 (2002-07-01), pages 1149 - 1153, XP002261350, ISSN: 0143-3334 *
VOGEL ULLA ET AL: "Two regions in chromosome 19q13.2-3 are associated with risk of lung cancer.", MUTATION RESEARCH, vol. 546, no. 1-2, 26 February 2004 (2004-02-26), pages 65 - 74, XP002407438, ISSN: 0027-5107 *
YIN JIAOYANG ET AL: "Multiple single nucleotide polymorphisms on human chromosome 19q13.2-3 associate with risk of basal cell carcinoma.", CANCER EPIDEMIOLOGY BIOMARKERS AND PREVENTION, vol. 11, no. 11, November 2002 (2002-11-01), pages 1449 - 1453, XP002261348, ISSN: 1055-9965 (ISSN print) *
YIN JIAOYANG ET AL: "Twelve single nucleotide polymorphisms on chromosome 19q13.2-13.3: Linkage disequilibria and associations with basal cell carcinoma in Danish psoriatic patients.", BIOCHEMICAL GENETICS, vol. 41, no. 1-2, February 2003 (2003-02-01), pages 27 - 37, XP002261351, ISSN: 0006-2928 *

Also Published As

Publication number Publication date
WO2006136170A2 (en) 2006-12-28

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