WO2006131566A3 - Oral ribavirin pharmaceutical compositions - Google Patents
Oral ribavirin pharmaceutical compositions Download PDFInfo
- Publication number
- WO2006131566A3 WO2006131566A3 PCT/EP2006/063070 EP2006063070W WO2006131566A3 WO 2006131566 A3 WO2006131566 A3 WO 2006131566A3 EP 2006063070 W EP2006063070 W EP 2006063070W WO 2006131566 A3 WO2006131566 A3 WO 2006131566A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ribavirin
- bio
- treatment
- oral
- absorption time
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to oral pharmaceutical compositions for the prevention and/or the treatment of viral diseases. This invention also addresses methods of prevention and/or treatment of these viral diseases, using these oral compositions. One of the main problems considered in the present invention, is to enhance the efficiency of anti-viral treatments, especially against Hepatitis C by means of ribavirin, for example in combination with interferon. The oral ribavirin antiviral composition according to the invention increases the bio-absorption time of ribavirin, and thus improves the treatment of the patients. Said composition comprises at least one modified release form of ribavirin which bio-absorption time BAT is greater than the bio-absorption time BAT* of a reference* immediate release form of ribavirin administered at the same dose; BAT being preferably comprised between 2 and 15 hours and more preferably between 4 and 12 hours. Said composition is a reservoir type form or a matricial type form. Said composition is a gastric retentive system or a multiparticulate form.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06763633A EP1888047A2 (en) | 2005-06-09 | 2006-06-09 | Oral ribavirin pharmaceutical compositions |
CA002609998A CA2609998A1 (en) | 2005-06-09 | 2006-06-09 | Oral ribavirin pharmaceutical compositions |
JP2008515226A JP2009514784A (en) | 2005-06-09 | 2006-06-09 | Oral ribavirin pharmaceutical composition |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IBPCT/IB2005/054434 | 2005-06-09 | ||
PCT/IB2005/054434 WO2006131790A2 (en) | 2005-06-09 | 2005-06-09 | Oral ribavirin pharmaceutical composition |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006131566A2 WO2006131566A2 (en) | 2006-12-14 |
WO2006131566A3 true WO2006131566A3 (en) | 2007-04-12 |
Family
ID=36791638
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2005/054434 WO2006131790A2 (en) | 2005-06-09 | 2005-06-09 | Oral ribavirin pharmaceutical composition |
PCT/EP2006/063070 WO2006131566A2 (en) | 2005-06-09 | 2006-06-09 | Oral ribavirin pharmaceutical compositions |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2005/054434 WO2006131790A2 (en) | 2005-06-09 | 2005-06-09 | Oral ribavirin pharmaceutical composition |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1888047A2 (en) |
JP (1) | JP2009514784A (en) |
CA (1) | CA2609998A1 (en) |
WO (2) | WO2006131790A2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2945947B1 (en) * | 2009-05-29 | 2011-07-29 | Flamel Tech Sa | FLOATING PHARMACEUTICAL COMPOSITIONS WITH CONTROLLED RELEASE |
WO2015197535A1 (en) * | 2014-06-23 | 2015-12-30 | Sanovel Ilac Sanayi Ve Ticaret A.S. | Modified release pharmaceutical compositions of sofosbuvir and ribavirin |
US20170151272A1 (en) * | 2014-06-23 | 2017-06-01 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | A novel pharmaceutical composition of sofosbuvir and ribavirin |
CN108354000B (en) * | 2018-04-19 | 2021-12-28 | 西安工程大学 | Slow-release and controlled-release microcapsule for fresh agricultural products and preparation method thereof |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6022562A (en) * | 1994-10-18 | 2000-02-08 | Flamel Technologies | Medicinal and/or nutritional microcapsules for oral administration |
US20030104056A1 (en) * | 2000-10-13 | 2003-06-05 | Rudnic Edward M. | Delayed release anti-viral product, use and formulation thereof |
US20040234601A1 (en) * | 2001-10-09 | 2004-11-25 | Valerie Legrand | Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles |
US20050019406A1 (en) * | 2002-09-19 | 2005-01-27 | Three Rivers Pharmaceuticals, Llc | Composition containing ribavirin and use thereof |
WO2005016370A1 (en) * | 2003-08-13 | 2005-02-24 | Howard J. Smith & Associates Pty Ltd | Method of treating viral infections |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2837100B1 (en) * | 2002-03-18 | 2004-07-23 | Flamel Tech Sa | MODIFIED RELEASE MICROCAPSULE-BASED TABLETS |
-
2005
- 2005-06-09 WO PCT/IB2005/054434 patent/WO2006131790A2/en active Application Filing
-
2006
- 2006-06-09 CA CA002609998A patent/CA2609998A1/en not_active Abandoned
- 2006-06-09 EP EP06763633A patent/EP1888047A2/en not_active Withdrawn
- 2006-06-09 WO PCT/EP2006/063070 patent/WO2006131566A2/en not_active Application Discontinuation
- 2006-06-09 JP JP2008515226A patent/JP2009514784A/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6022562A (en) * | 1994-10-18 | 2000-02-08 | Flamel Technologies | Medicinal and/or nutritional microcapsules for oral administration |
US20030104056A1 (en) * | 2000-10-13 | 2003-06-05 | Rudnic Edward M. | Delayed release anti-viral product, use and formulation thereof |
US20040234601A1 (en) * | 2001-10-09 | 2004-11-25 | Valerie Legrand | Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles |
US20050019406A1 (en) * | 2002-09-19 | 2005-01-27 | Three Rivers Pharmaceuticals, Llc | Composition containing ribavirin and use thereof |
WO2005016370A1 (en) * | 2003-08-13 | 2005-02-24 | Howard J. Smith & Associates Pty Ltd | Method of treating viral infections |
Non-Patent Citations (3)
Title |
---|
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BEI, QINGSHENG: "Release-sustained pellet of ribavirin", XP002395861, retrieved from STN Database accession no. 2005:353828 * |
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; TAO, XIUMEI ET AL: "Preparation of ribavirin sustained - release pellets by centrifugal granulation technology", XP002395860, retrieved from STN Database accession no. 2005:500395 * |
ZHONGGUO YAOXUE ZAZHI (BEIJING, CHINA) , 39(12), 925-927 CODEN: ZYZAEU; ISSN: 1001-2494, 2004 * |
Also Published As
Publication number | Publication date |
---|---|
JP2009514784A (en) | 2009-04-09 |
WO2006131566A2 (en) | 2006-12-14 |
WO2006131790A3 (en) | 2007-07-05 |
WO2006131790A2 (en) | 2006-12-14 |
CA2609998A1 (en) | 2006-12-14 |
EP1888047A2 (en) | 2008-02-20 |
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