WO2006129257A3 - Ketolide derivatives as antibacterial agents - Google Patents

Ketolide derivatives as antibacterial agents Download PDF

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Publication number
WO2006129257A3
WO2006129257A3 PCT/IB2006/051686 IB2006051686W WO2006129257A3 WO 2006129257 A3 WO2006129257 A3 WO 2006129257A3 IB 2006051686 W IB2006051686 W IB 2006051686W WO 2006129257 A3 WO2006129257 A3 WO 2006129257A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydrogen
formula
independently
spp
ketolide
Prior art date
Application number
PCT/IB2006/051686
Other languages
French (fr)
Other versions
WO2006129257A2 (en
Inventor
Biswajit Das
Anjan Chakrabarti
Gobind Singh Kapkoti
Atul Kashinath Hajare
Rita Katoch
Ashok Rattan
Original Assignee
Ranbaxy Lab Ltd
Biswajit Das
Anjan Chakrabarti
Gobind Singh Kapkoti
Atul Kashinath Hajare
Rita Katoch
Ashok Rattan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd, Biswajit Das, Anjan Chakrabarti, Gobind Singh Kapkoti, Atul Kashinath Hajare, Rita Katoch, Ashok Rattan filed Critical Ranbaxy Lab Ltd
Publication of WO2006129257A2 publication Critical patent/WO2006129257A2/en
Publication of WO2006129257A3 publication Critical patent/WO2006129257A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

The present invention provides ketolide derivatives, which can be used as antibacterial agents. In particular, compounds described herein can be used for treating or preventing conditions caused by or contributed to by gram positive, gram negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus or Enterobactericeae. Also provided are processes for preparing such ketolide. derivatives, pharmaceutical compositions thereof, and methods of treating bacterial infections. The compounds have the following structure, Formula (I), wherein R can be Formula (II), (wherein Zi can be hydrogen or melhyl, Z2 can be hydrogen, halogen, C1-3 alkyl, C1-3 alkoxy, amino, nitro, cyano or amido, Z3 can be hydrogen, fluorine, chlorine, bromine or iodine, X1 can be CR4, CR4 R’4N, NR4, O or S, X2 can be CR4 or N wherein R4 and R'4 independently in each occurrence can be hydrogen or C1-3 alky, R2 and R3 can be independently Formula (III), wherein, X3-X13 can be independenËy C(R4 ) 0-2, N(R4)0-1, O or S, R5-R10 can be independently hydrogen, halogen, C1-3 alkyl, C1-3 alkoxy, amino, nilro, cyano, aryl or heteroaryl), Y is hydrogen or methyl, and is an optional single bond.
PCT/IB2006/051686 2005-05-30 2006-05-26 Ketolide derivatives as antibacterial agents WO2006129257A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1383DE2005 2005-05-30
IN1383/DEL/2005 2005-05-30

Publications (2)

Publication Number Publication Date
WO2006129257A2 WO2006129257A2 (en) 2006-12-07
WO2006129257A3 true WO2006129257A3 (en) 2007-02-08

Family

ID=36954773

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/051686 WO2006129257A2 (en) 2005-05-30 2006-05-26 Ketolide derivatives as antibacterial agents

Country Status (1)

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WO (1) WO2006129257A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110040078A1 (en) * 2007-10-25 2011-02-17 Siegfried Wolf Process for the production of telithromycin

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
US5635485A (en) * 1994-05-03 1997-06-03 Roussel Uclaf Erythromycin compounds
WO1999016779A1 (en) * 1997-09-30 1999-04-08 Abbott Laboratories 3'-n-modified 6-o-substituted erythromycin ketolide derivatives having antibacterial activity
WO2003004509A2 (en) * 2001-07-03 2003-01-16 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
US5635485A (en) * 1994-05-03 1997-06-03 Roussel Uclaf Erythromycin compounds
WO1999016779A1 (en) * 1997-09-30 1999-04-08 Abbott Laboratories 3'-n-modified 6-o-substituted erythromycin ketolide derivatives having antibacterial activity
WO2003004509A2 (en) * 2001-07-03 2003-01-16 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DENIS, ALEXIS ET AL: "Novel fluoroketolides: Synthesis and antibacterial activity", DRUGS OF THE FUTURE , 26(10), 975-984 CODEN: DRFUD4; ISSN: 0377-8282, 2001, XP002399583 *
DENIS, ALEXIS ET AL: "Synthesis and antibacterial activity of HMR 3647, a new ketolide highly potent against erythromycin-resistant and susceptible pathogens", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS , 9(21), 3075-3080 CODEN: BMCLE8; ISSN: 0960-894X, 1999, XP004181010 *

Also Published As

Publication number Publication date
WO2006129257A2 (en) 2006-12-07

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