WO2006129092A3 - Use of bacteriophage in medicaments - Google Patents

Use of bacteriophage in medicaments Download PDF

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Publication number
WO2006129092A3
WO2006129092A3 PCT/GB2006/001992 GB2006001992W WO2006129092A3 WO 2006129092 A3 WO2006129092 A3 WO 2006129092A3 GB 2006001992 W GB2006001992 W GB 2006001992W WO 2006129092 A3 WO2006129092 A3 WO 2006129092A3
Authority
WO
WIPO (PCT)
Prior art keywords
medicaments
treatment
bacteriophages
prevention
relates
Prior art date
Application number
PCT/GB2006/001992
Other languages
French (fr)
Other versions
WO2006129092A2 (en
Inventor
Laura Jane Violet Piddock
Martin John Woodward
Original Assignee
Univ Birmingham
Laura Jane Violet Piddock
Martin John Woodward
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Birmingham, Laura Jane Violet Piddock, Martin John Woodward filed Critical Univ Birmingham
Publication of WO2006129092A2 publication Critical patent/WO2006129092A2/en
Publication of WO2006129092A3 publication Critical patent/WO2006129092A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/00021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/00032—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent

Abstract

The present invention relates to medicaments suitable for use in the prevention and/or treatment of bacterial infection and/or colonisation. More particularly, the invention relates to medicaments comprising bacteriophages capable of binding to bacterial efflux pump components suitable for use in the prevention or treatment of diseases associated with Gram-negative bacteria. The invention also provides methods of treatment and methods of food preparation utilising such bacteriophages, as well as an assay by which such bacteriophages may be identified.
PCT/GB2006/001992 2005-06-02 2006-06-02 Use of bacteriophage in medicaments WO2006129092A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0511204.0A GB0511204D0 (en) 2005-06-02 2005-06-02 Medicaments
GB0511204.0 2005-06-02

Publications (2)

Publication Number Publication Date
WO2006129092A2 WO2006129092A2 (en) 2006-12-07
WO2006129092A3 true WO2006129092A3 (en) 2007-01-18

Family

ID=34834990

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/001992 WO2006129092A2 (en) 2005-06-02 2006-06-02 Use of bacteriophage in medicaments

Country Status (2)

Country Link
GB (1) GB0511204D0 (en)
WO (1) WO2006129092A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070292397A1 (en) * 2006-06-19 2007-12-20 Mcnulty Amy K Method for the detection and neutralization of bacteria
EP2030623A1 (en) 2007-08-17 2009-03-04 Nestec S.A. Preventing and/or treating metabolic disorders by modulating the amount of enterobacteria
WO2009104731A1 (en) * 2008-02-21 2009-08-27 味の素株式会社 L-cysteine-producing bacterium, and method for production of l-cysteine
EP3448400A4 (en) * 2016-04-25 2019-11-13 Yale University Bacteriophage compositions and uses thereof
CN106868179A (en) * 2017-03-30 2017-06-20 佟青 Efflux pump SMeDEF combines the method for mediation germ oligotrophy unit cell Multiresistant genes positioning with I class integrase gene
CN111088269B (en) * 2019-12-17 2020-11-20 中国科学院深圳先进技术研究院 OprJ-N-M fusion gene, fusion protein thereof, preparation method of fusion protein and application

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995023848A1 (en) * 1994-03-01 1995-09-08 Merck Patent Gmbh Selective virus culture
WO2002038104A2 (en) * 2000-11-13 2002-05-16 Iowa State University Research Foundation, Inc. Compositions and methods for reducing the amount of salmonella in livestock
WO2003103578A2 (en) * 2002-06-05 2003-12-18 Iowa State University Research Foundation, Inc. Bacteriophage and enzymes lytic to salmonellae
WO2005023010A2 (en) * 2003-09-05 2005-03-17 The University Of Nottingham Disinfection of foodstuffs

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995023848A1 (en) * 1994-03-01 1995-09-08 Merck Patent Gmbh Selective virus culture
WO2002038104A2 (en) * 2000-11-13 2002-05-16 Iowa State University Research Foundation, Inc. Compositions and methods for reducing the amount of salmonella in livestock
WO2003103578A2 (en) * 2002-06-05 2003-12-18 Iowa State University Research Foundation, Inc. Bacteriophage and enzymes lytic to salmonellae
WO2005023010A2 (en) * 2003-09-05 2005-03-17 The University Of Nottingham Disinfection of foodstuffs

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
ANDERSON E S ET AL: "Bacteriophage typing of enteric pathogens and staphylococci and its use in epidemiology.", JOURNAL OF CLINICAL PATHOLOGY. MAY 1956, vol. 9, no. 2, May 1956 (1956-05-01), pages 94 - 127, XP002404413, ISSN: 0021-9746 *
CARLTON R M: "PHAGE THERAPY: PAST HISTORY AND FUTURE PROSPECTS", ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS, POLISH ACADEMY OF SCIENCES, WROCLAW, PL, vol. 47, no. 5, 1999, pages 267 - 274, XP001199870, ISSN: 0004-069X *
CONNERTON P L ET AL: "Longitudinal study of Campylobacter jejuni bacteriophages and their hosts from broiler chickens", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, WASHINGTON,DC, US, vol. 70, no. 7, July 2004 (2004-07-01), pages 3877 - 3883, XP002313914, ISSN: 0099-2240 *
EL-SHIBINY A ET AL: "Enumeration and diversity of campylobacters and bacteriophages isolated during the rearing cycles of free-range and organic chickens.", APPLIED AND ENVIRONMENTAL MICROBIOLOGY. MAR 2005, vol. 71, no. 3, March 2005 (2005-03-01), pages 1259 - 1266, XP002404410, ISSN: 0099-2240 *
GERMAN G J ET AL: "The TolC protein of Escherichia coli serves as a cell-surface receptor for the newly characterized TLS bacteriophage", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. 308, no. 4, 11 May 2001 (2001-05-11), pages 579 - 585, XP004480454, ISSN: 0022-2836 *
HUSAIN FASAHATH ET AL: "Interaction between the TolC and AcrA proteins of a multidrug efflux system of Escherichia coli.", JOURNAL OF BACTERIOLOGY. DEC 2004, vol. 186, no. 24, December 2004 (2004-12-01), pages 8533 - 8536, XP002404027, ISSN: 0021-9193 *
SCHMIEGER H: "Molecular survey of the Salmonella phage typing system of Anderson.", JOURNAL OF BACTERIOLOGY. MAR 1999, vol. 181, no. 5, March 1999 (1999-03-01), pages 1630 - 1635, XP002404411, ISSN: 0021-9193 *
THIEL KARL: "Old dogma, new tricks--21st Century phage therapy.", NATURE BIOTECHNOLOGY. JAN 2004, vol. 22, no. 1, January 2004 (2004-01-01), pages 31 - 36, XP002404412, ISSN: 1087-0156 *

Also Published As

Publication number Publication date
GB0511204D0 (en) 2005-07-06
WO2006129092A2 (en) 2006-12-07

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