WO2006125194A3 - Derives de piperazine et leurs utilisations en tant qu'agents therapeutiques - Google Patents

Derives de piperazine et leurs utilisations en tant qu'agents therapeutiques Download PDF

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Publication number
WO2006125194A3
WO2006125194A3 PCT/US2006/019612 US2006019612W WO2006125194A3 WO 2006125194 A3 WO2006125194 A3 WO 2006125194A3 US 2006019612 W US2006019612 W US 2006019612W WO 2006125194 A3 WO2006125194 A3 WO 2006125194A3
Authority
WO
WIPO (PCT)
Prior art keywords
therapeutic agents
piperazine derivatives
mammal
formula
disclosed
Prior art date
Application number
PCT/US2006/019612
Other languages
English (en)
Other versions
WO2006125194A2 (fr
Inventor
Shaoyi Sun
Zaihui Zhang
Original Assignee
Xenon Pharmaceuticals Inc
Roth Carol J
Shaoyi Sun
Zaihui Zhang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenon Pharmaceuticals Inc, Roth Carol J, Shaoyi Sun, Zaihui Zhang filed Critical Xenon Pharmaceuticals Inc
Publication of WO2006125194A2 publication Critical patent/WO2006125194A2/fr
Publication of WO2006125194A3 publication Critical patent/WO2006125194A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/195—Radicals derived from nitrogen analogues of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des méthodes de traitement d'une maladie ou d'un trouble à médiation SCD chez un mammalien, de préférence, un humain. Ces méthodes consistent à administrer à un mammalien le nécessitant un composé de formule (I), où p, K, W, V, R2, R3, R4, R4a, R5, R6, R7 et R7a sont tels que définis dans l'invention. Cette invention a aussi pour objet des compositions pharmaceutiques contenant les composés de formule (I).
PCT/US2006/019612 2005-05-19 2006-05-19 Derives de piperazine et leurs utilisations en tant qu'agents therapeutiques WO2006125194A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68256805P 2005-05-19 2005-05-19
US60/682,568 2005-05-19

Publications (2)

Publication Number Publication Date
WO2006125194A2 WO2006125194A2 (fr) 2006-11-23
WO2006125194A3 true WO2006125194A3 (fr) 2007-01-04

Family

ID=37056159

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/019612 WO2006125194A2 (fr) 2005-05-19 2006-05-19 Derives de piperazine et leurs utilisations en tant qu'agents therapeutiques

Country Status (1)

Country Link
WO (1) WO2006125194A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0719122A2 (pt) 2006-08-24 2013-12-10 Novartis Ag Compostos orgânicos
WO2008157844A1 (fr) 2007-06-21 2008-12-24 Forest Laboratories Holdings Limited Nouveaux dérivés de pipérazine en tant qu'inhibiteurs de stéaroyl-coa désaturase
ES2545864T3 (es) 2009-02-17 2015-09-16 Merck Canada Inc. Nuevos compuestos espiránicos útiles como inhibidores de la estearoil-coenzima A delta-9 desaturasa
EP2459568A4 (fr) 2009-07-28 2013-02-27 Merck Frosst Canada Ltd Nouveaux composés spiro utiles en tant qu'inhibiteurs de la stéaroyl-coenzyme a delta-9 désaturase
CA2850836A1 (fr) 2011-10-15 2013-04-18 Genentech, Inc. Procedes d'utilisation d'antagonistes de scd1
EP2852387A2 (fr) 2012-05-22 2015-04-01 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Inhibiteurs sélectifs de cellules indifférenciées
WO2018081167A1 (fr) 2016-10-24 2018-05-03 Yumanity Therapeutics Composés et utilisations de ces derniers
WO2018129403A1 (fr) 2017-01-06 2018-07-12 Yumanity Therapeutics Méthodes de traitement de troubles neurologiques
CA3083000A1 (fr) 2017-10-24 2019-05-02 Yumanity Therapeutics, Inc. Composes et utilisations de ces composes
CA3127791A1 (fr) 2019-01-24 2020-07-30 Yumanity Therapeutics, Inc. Composes et leurs utilisations

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005011657A2 (fr) * 2003-07-30 2005-02-10 Xenon Pharmaceuticals Inc. Derives de piperazine et utilisation comme agents therapeutiques
WO2005011653A2 (fr) * 2003-07-30 2005-02-10 Xenon Pharmaceuticals Inc. Derives de pyridazine et utilisation de ceux-ci en tant qu'agents therapeutiques
WO2005011654A2 (fr) * 2003-07-29 2005-02-10 Xenon Pharmaceuticals Inc. Derives de pyridyle et utilisation de ceux-ci en tant qu'agents therapeutiques

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005011654A2 (fr) * 2003-07-29 2005-02-10 Xenon Pharmaceuticals Inc. Derives de pyridyle et utilisation de ceux-ci en tant qu'agents therapeutiques
WO2005011657A2 (fr) * 2003-07-30 2005-02-10 Xenon Pharmaceuticals Inc. Derives de piperazine et utilisation comme agents therapeutiques
WO2005011653A2 (fr) * 2003-07-30 2005-02-10 Xenon Pharmaceuticals Inc. Derives de pyridazine et utilisation de ceux-ci en tant qu'agents therapeutiques

Also Published As

Publication number Publication date
WO2006125194A2 (fr) 2006-11-23

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