WO2006125050A3 - Biobarcode assays for ultra high sensitive detection - Google Patents

Biobarcode assays for ultra high sensitive detection Download PDF

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Publication number
WO2006125050A3
WO2006125050A3 PCT/US2006/019170 US2006019170W WO2006125050A3 WO 2006125050 A3 WO2006125050 A3 WO 2006125050A3 US 2006019170 W US2006019170 W US 2006019170W WO 2006125050 A3 WO2006125050 A3 WO 2006125050A3
Authority
WO
WIPO (PCT)
Prior art keywords
biobarcode
assays
ultra high
sensitive detection
high sensitive
Prior art date
Application number
PCT/US2006/019170
Other languages
French (fr)
Other versions
WO2006125050A2 (en
Inventor
Yijia Paul Bao
Tai-Fen Wei
Hao An
Liangxiu He
Original Assignee
Nanosphere Inc
Yijia Paul Bao
Tai-Fen Wei
Hao An
Liangxiu He
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanosphere Inc, Yijia Paul Bao, Tai-Fen Wei, Hao An, Liangxiu He filed Critical Nanosphere Inc
Publication of WO2006125050A2 publication Critical patent/WO2006125050A2/en
Publication of WO2006125050A3 publication Critical patent/WO2006125050A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/10—Oligonucleotides as tagging agents for labelling antibodies

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention provides an extremely sensitive, reliable, and adaptable detection method of chemical detection through signal amplification from a reporter reagent capable of selectively binding to the target chemical of interest. The invention utilizes a detection reagent containing a streptavidin-biotin complex or a particle that has been derivatized to include on its surface selective binding compounds that specifically bind to the target chemical species and a large number of copies of a pre-selected reporter moiety.
PCT/US2006/019170 2005-05-17 2006-05-17 Biobarcode assays for ultra high sensitive detection WO2006125050A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US68174005P 2005-05-17 2005-05-17
US60/681,740 2005-05-17
US68216005P 2005-05-18 2005-05-18
US60/682,160 2005-05-18

Publications (2)

Publication Number Publication Date
WO2006125050A2 WO2006125050A2 (en) 2006-11-23
WO2006125050A3 true WO2006125050A3 (en) 2007-02-08

Family

ID=37075627

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/019170 WO2006125050A2 (en) 2005-05-17 2006-05-17 Biobarcode assays for ultra high sensitive detection

Country Status (1)

Country Link
WO (1) WO2006125050A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008140620A2 (en) * 2006-12-21 2008-11-20 Nanosphere, Inc. Ultra sensitive biomolecule detection using double stranded dna co-loaded gold nanoparticles and co-immobilized capture molecules
KR20100042082A (en) 2008-10-15 2010-04-23 삼성전자주식회사 Solid support with enhanced density of a signal material, kit containing the same and method for detecting target material using the same
DE102010033107A1 (en) 2010-08-02 2012-02-02 Aj Innuscreen Gmbh Detection of specific nucleic acid sequences by fluorescence quenching
WO2012016936A1 (en) 2010-07-31 2012-02-09 Aj Innuscreen Gmbh Detection of specific nucleic acid sequences by means of fluorescence quenching
CN111693691B (en) * 2019-03-14 2023-09-05 天津华科泰生物技术有限公司 Polymer label based on porphyrin structure

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050037397A1 (en) * 2001-03-28 2005-02-17 Nanosphere, Inc. Bio-barcode based detection of target analytes
WO2005113817A2 (en) * 2004-05-03 2005-12-01 Nanosphere, Inc. Aptamer-nanoparticle conjugates and method of use for target analyte detection

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050037397A1 (en) * 2001-03-28 2005-02-17 Nanosphere, Inc. Bio-barcode based detection of target analytes
WO2005113817A2 (en) * 2004-05-03 2005-12-01 Nanosphere, Inc. Aptamer-nanoparticle conjugates and method of use for target analyte detection

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NAM JWA-MIN ET AL: "Bio-bar-code-based DNA detection with PCR-like sensitivity.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 19 MAY 2004, vol. 126, no. 19, 19 May 2004 (2004-05-19), pages 5932 - 5933, XP002403224, ISSN: 0002-7863 *
NAM JWA-MIN ET AL: "Nanoparticle-based bio-bar codes for the ultrasensitive detection of proteins.", SCIENCE. 26 SEP 2003, vol. 301, no. 5641, 26 September 2003 (2003-09-26), pages 1884 - 1886, XP002403223, ISSN: 1095-9203 *

Also Published As

Publication number Publication date
WO2006125050A2 (en) 2006-11-23

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