WO2006124884A3 - Dosing regimen - Google Patents

Dosing regimen Download PDF

Info

Publication number
WO2006124884A3
WO2006124884A3 PCT/US2006/018897 US2006018897W WO2006124884A3 WO 2006124884 A3 WO2006124884 A3 WO 2006124884A3 US 2006018897 W US2006018897 W US 2006018897W WO 2006124884 A3 WO2006124884 A3 WO 2006124884A3
Authority
WO
WIPO (PCT)
Prior art keywords
dosing regimen
tert
drug
dephenyl
debenzoyl
Prior art date
Application number
PCT/US2006/018897
Other languages
French (fr)
Other versions
WO2006124884A2 (en
Inventor
Maurizio Voi
Original Assignee
Bristol Myers Squibb Co
Maurizio Voi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co, Maurizio Voi filed Critical Bristol Myers Squibb Co
Publication of WO2006124884A2 publication Critical patent/WO2006124884A2/en
Publication of WO2006124884A3 publication Critical patent/WO2006124884A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

This invention relates to a twice weekly administration of 3'-tert-Butyl-3'-N-tert-butyloxycarbonyl-4-deacetyl-3'-dephenyl-3'-N-debenzoyl-4-O-methoxycarbonyl-paclitaxel that has been found to reduce the neurotoxicity of the drug and allow for better patient compliance in the use of this oral cancer drug.
PCT/US2006/018897 2005-05-13 2006-05-12 Dosing regimen WO2006124884A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68069805P 2005-05-13 2005-05-13
US60/680,698 2005-05-13

Publications (2)

Publication Number Publication Date
WO2006124884A2 WO2006124884A2 (en) 2006-11-23
WO2006124884A3 true WO2006124884A3 (en) 2007-04-19

Family

ID=37432028

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/018897 WO2006124884A2 (en) 2005-05-13 2006-05-12 Dosing regimen

Country Status (2)

Country Link
TW (1) TW200722080A (en)
WO (1) WO2006124884A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6476242B1 (en) * 1997-12-31 2002-11-05 Bristol-Myers Squibb Company 2-aroyl-4-acyl paclitaxel (Taxol) analogs
US6515004B1 (en) * 1999-12-15 2003-02-04 Bristol-Myers Squibb Company N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6476242B1 (en) * 1997-12-31 2002-11-05 Bristol-Myers Squibb Company 2-aroyl-4-acyl paclitaxel (Taxol) analogs
US6515004B1 (en) * 1999-12-15 2003-02-04 Bristol-Myers Squibb Company N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PLUMMER R. ET AL.: "Phase I and pharmacokinetic study of the new taxane analog BMS-184476 given weekly in patients with advanced malignancies", CLIN. CANCER RES., vol. 8, no. 9, 2002, pages 2788 - 2797, XP003010610 *

Also Published As

Publication number Publication date
WO2006124884A2 (en) 2006-11-23
TW200722080A (en) 2007-06-16

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