WO2006124544A3 - Use of tyrosine kinase inhibitors in the treatment of metabolic disorders - Google Patents

Use of tyrosine kinase inhibitors in the treatment of metabolic disorders Download PDF

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Publication number
WO2006124544A3
WO2006124544A3 PCT/US2006/018342 US2006018342W WO2006124544A3 WO 2006124544 A3 WO2006124544 A3 WO 2006124544A3 US 2006018342 W US2006018342 W US 2006018342W WO 2006124544 A3 WO2006124544 A3 WO 2006124544A3
Authority
WO
WIPO (PCT)
Prior art keywords
tyrosine kinase
kinase inhibitors
treatment
metabolic disorders
adipocyte
Prior art date
Application number
PCT/US2006/018342
Other languages
French (fr)
Other versions
WO2006124544A2 (en
Inventor
Jeffrey Porter
Thomas Edward Hughes
Original Assignee
Novartis Ag
Novartis Pharma Gmbh
Jeffrey Porter
Thomas Edward Hughes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Novartis Pharma Gmbh, Jeffrey Porter, Thomas Edward Hughes filed Critical Novartis Ag
Publication of WO2006124544A2 publication Critical patent/WO2006124544A2/en
Publication of WO2006124544A3 publication Critical patent/WO2006124544A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

The present invention relates to the use of c-Abl-, PDGF-R-, c-kit-, or ARG-tyrosine kinase inhibitors, or pharmaceutically acceptable salts thereof, for the treatment, amelioration, and diagnosis of disorders associated with aberrant expression of adipocyte-specific peptide hormone in a patient, e.g., metabolic disorders, e.g., type I diabetes or type II diabetes, and for the manufacture of pharmaceutical compositions for the treatment, amelioration, and diagnosis of disorders associated with aberrant expression of adipocyte-specific peptide hormone in a patient. Examples of c-Abl-, PDGF-R-, c-kit-, or ARG-tyrosine kinase inhibitors include Compound I and Compound II, and pharmaceutically acceptable salts thereof. The ability of the c-Abl-, PDGF-R-, c-kit-, or ARG-tyrosine kinase inhibitors, or pharmaceutically acceptable salts thereof, to treat metabolic disorders is based at least in part on their ability to bind adipocyte-specific peptide hormones such as adiponectin.
PCT/US2006/018342 2005-05-13 2006-05-11 Use of tyrosine kinase inhibitors in the treatment of metabolic disorders WO2006124544A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68071405P 2005-05-13 2005-05-13
US60/680,714 2005-05-13

Publications (2)

Publication Number Publication Date
WO2006124544A2 WO2006124544A2 (en) 2006-11-23
WO2006124544A3 true WO2006124544A3 (en) 2007-09-07

Family

ID=37431881

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/018342 WO2006124544A2 (en) 2005-05-13 2006-05-11 Use of tyrosine kinase inhibitors in the treatment of metabolic disorders

Country Status (1)

Country Link
WO (1) WO2006124544A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102812011A (en) 2009-11-16 2012-12-05 梅利科技公司 [1,5]-diazocin Derivatives
IL234962A0 (en) * 2014-10-02 2015-01-29 Yeda Res & Dev Use of agents for treating fat-related disorders
CN116173023A (en) * 2022-09-09 2023-05-30 中南民族大学 New application of lenvatinib in preventing and treating type II diabetes

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005009367A2 (en) * 2003-07-17 2005-02-03 Ambit Biosciences Corporation Treatment of diseases with kinase inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005009367A2 (en) * 2003-07-17 2005-02-03 Ambit Biosciences Corporation Treatment of diseases with kinase inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LASSILA M ET AL: "IMATINIB ATTENUATES DIABETES-ASSOCIATED ATHEROSCLEROSIS", ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY, vol. 24, no. 5, May 2004 (2004-05-01), pages 935 - 942, XP008037837, ISSN: 1079-5642 *

Also Published As

Publication number Publication date
WO2006124544A2 (en) 2006-11-23

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