WO2006124446A3 - Sustained release microparticles for pulmonary delivery - Google Patents

Sustained release microparticles for pulmonary delivery Download PDF

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Publication number
WO2006124446A3
WO2006124446A3 PCT/US2006/018053 US2006018053W WO2006124446A3 WO 2006124446 A3 WO2006124446 A3 WO 2006124446A3 US 2006018053 W US2006018053 W US 2006018053W WO 2006124446 A3 WO2006124446 A3 WO 2006124446A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical agent
lipid
microparticles
matrix
sustained release
Prior art date
Application number
PCT/US2006/018053
Other languages
French (fr)
Other versions
WO2006124446A2 (en
Inventor
Stelios T Tzannis
Negar Sadrzadeh
Helen Schiavone
Renee Labiris
Original Assignee
Nektar Therapeutics
Stelios T Tzannis
Negar Sadrzadeh
Helen Schiavone
Renee Labiris
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nektar Therapeutics, Stelios T Tzannis, Negar Sadrzadeh, Helen Schiavone, Renee Labiris filed Critical Nektar Therapeutics
Publication of WO2006124446A2 publication Critical patent/WO2006124446A2/en
Publication of WO2006124446A3 publication Critical patent/WO2006124446A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats

Abstract

A composition of microparticles for delivery to the pulmonary system provides sustained release of a pharmaceutical agent. The microparticles comprise a lipid structural matrix comprising a multilamellar structure of lipid bilayers having lipid chains ordered in an LβL phase. The lipid matrix at least partially encapsulates the pharmaceutical agent at a bilayer interface formed between head groups of adjacent lipid layers. The microparticles are prepared by heating a precursor formulation comprising a solvent, matrix-forming excipient and pharmaceutical agent to a temperature above the liquid-crystalline transition temperature Tc of the matrix-forming excipient and below the melting or denaturation point of the pharmaceutical agent. The solvent is then removed to form microparticles with partially encapsulated pharmaceutical agent.
PCT/US2006/018053 2005-05-12 2006-05-09 Sustained release microparticles for pulmonary delivery WO2006124446A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US12785405A 2005-05-12 2005-05-12
US11/127,854 2005-05-12
US65148905P 2005-06-22 2005-06-22
US60/651,489 2005-06-22

Publications (2)

Publication Number Publication Date
WO2006124446A2 WO2006124446A2 (en) 2006-11-23
WO2006124446A3 true WO2006124446A3 (en) 2007-06-14

Family

ID=37431844

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/018053 WO2006124446A2 (en) 2005-05-12 2006-05-09 Sustained release microparticles for pulmonary delivery

Country Status (1)

Country Link
WO (1) WO2006124446A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009031274A1 (en) * 2009-06-30 2011-01-13 Justus-Liebig-Universität Giessen Liposomes for pulmonary application
EP2611416B1 (en) * 2010-09-03 2015-08-19 Pharmaterials Ltd. Pharmaceutical composition suitable for use in a dry powder inhaler
EP4056038A1 (en) * 2021-03-10 2022-09-14 Basf Se Microparticles containing active substances

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999016422A1 (en) * 1997-09-29 1999-04-08 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
WO2001013891A2 (en) * 1999-08-25 2001-03-01 Advanced Inhalation Research, Inc. Modulation of release from dry powder formulations
US20040042970A1 (en) * 2002-03-20 2004-03-04 Advanced Inhalation Research, Inc. Inhalable sustained therapeutic formulations
WO2004054556A1 (en) * 2002-12-13 2004-07-01 Adagit Pharmaceutical porous particles

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999016422A1 (en) * 1997-09-29 1999-04-08 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
WO2001013891A2 (en) * 1999-08-25 2001-03-01 Advanced Inhalation Research, Inc. Modulation of release from dry powder formulations
US20040042970A1 (en) * 2002-03-20 2004-03-04 Advanced Inhalation Research, Inc. Inhalable sustained therapeutic formulations
WO2004054556A1 (en) * 2002-12-13 2004-07-01 Adagit Pharmaceutical porous particles

Also Published As

Publication number Publication date
WO2006124446A2 (en) 2006-11-23

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