WO2006123156A3 - Mass spectrometer apparatus - Google Patents

Mass spectrometer apparatus Download PDF

Info

Publication number
WO2006123156A3
WO2006123156A3 PCT/GB2006/001833 GB2006001833W WO2006123156A3 WO 2006123156 A3 WO2006123156 A3 WO 2006123156A3 GB 2006001833 W GB2006001833 W GB 2006001833W WO 2006123156 A3 WO2006123156 A3 WO 2006123156A3
Authority
WO
WIPO (PCT)
Prior art keywords
calibration
compounds
ionisation
ionizable
volatile
Prior art date
Application number
PCT/GB2006/001833
Other languages
French (fr)
Other versions
WO2006123156A2 (en
Inventor
John George Luke
Richard Sleeman
James Francis Carter
Original Assignee
Mass Spec Analytical Ltd
John George Luke
Richard Sleeman
James Francis Carter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mass Spec Analytical Ltd, John George Luke, Richard Sleeman, James Francis Carter filed Critical Mass Spec Analytical Ltd
Publication of WO2006123156A2 publication Critical patent/WO2006123156A2/en
Publication of WO2006123156A3 publication Critical patent/WO2006123156A3/en

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0009—Calibration of the apparatus
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0459—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for solid samples
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0468—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample
    • H01J49/049—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample with means for applying heat to desorb the sample; Evaporation
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/14—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers
    • H01J49/145—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers using chemical ionisation

Abstract

A method for the calibration of atmospheric pressure ionisation analytical apparatus including means for ionising a gaseous test sample comprises supplying to the ionising means a mixture of ionizable calibration compounds in solid form, the compounds having respective ionized species of known different molecular weights. The ionisation may be chemical ionisation, the apparatus including means for heating the test sample, the calibration compounds being volatile in the heating means. The invention includes a mixture of ionizable calibration compounds in solid form for use in calibration of desorption analytical apparatus, the compounds being volatile and having respective species when ionized of known different molecular weights.
PCT/GB2006/001833 2005-05-18 2006-05-18 Mass spectrometer apparatus WO2006123156A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0510171A GB0510171D0 (en) 2005-05-18 2005-05-18 Mass spectrometer apparatus
GB0510171.2 2005-05-18

Publications (2)

Publication Number Publication Date
WO2006123156A2 WO2006123156A2 (en) 2006-11-23
WO2006123156A3 true WO2006123156A3 (en) 2007-04-26

Family

ID=34708397

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/001833 WO2006123156A2 (en) 2005-05-18 2006-05-18 Mass spectrometer apparatus

Country Status (2)

Country Link
GB (1) GB0510171D0 (en)
WO (1) WO2006123156A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4224031A (en) * 1977-11-15 1980-09-23 Mee John M L CI Mass spectrometric analysis of physiologically active compounds
US6207954B1 (en) * 1997-09-12 2001-03-27 Analytica Of Branford, Inc. Multiple sample introduction mass spectrometry
WO2003075772A2 (en) * 2002-03-11 2003-09-18 Pawliszyn Janusz B Micro-devices and analytical procedures for investigation of biological systems

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4224031A (en) * 1977-11-15 1980-09-23 Mee John M L CI Mass spectrometric analysis of physiologically active compounds
US6207954B1 (en) * 1997-09-12 2001-03-27 Analytica Of Branford, Inc. Multiple sample introduction mass spectrometry
WO2003075772A2 (en) * 2002-03-11 2003-09-18 Pawliszyn Janusz B Micro-devices and analytical procedures for investigation of biological systems

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BECKER J S ET AL: "State-of-the-art in inorganic mass spectrometry for analysis of high-purity materials", INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 228, no. 2-3, 15 August 2003 (2003-08-15), pages 127 - 150, XP004442599, ISSN: 1387-3806 *
LORD H ET AL: "Evolution of solid-phase microextraction technology", JOURNAL OF CHROMATOGRAPHY, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 885, no. 1-2, July 2000 (2000-07-01), pages 153 - 193, XP004206006, ISSN: 0021-9673 *
PRZYK E ET AL: "Use of porous glass and silica gel as support media of a surface compound for generation of analytes in gaseous standard mixtures. New method for the determination of the amount of analyte generated", JOURNAL OF CHROMATOGRAPHY A, ELSEVIER, AMSTERDAM, NL, vol. 928, no. 1, 31 August 2001 (2001-08-31), pages 99 - 108, XP004302029, ISSN: 0021-9673 *
ROBERTS D J ET AL: "APPLICATION OF TANDEM MASS SPECTROMETRY TO THE DETECTION OF DRUGS ON CASH", SPECTROSCOPY EUROPE, WEINHEIM, DE, vol. 9, no. 6, 1997, pages 20,22 - 24, XP008073637, ISSN: 0966-0941 *
ZHOUYAO ZHANG ET AL: "SOLID-PHASE MICROEXTRACTION", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. COLUMBUS, US, vol. 66, no. 17, 1 September 1994 (1994-09-01), pages 844A - 853A, XP000466960, ISSN: 0003-2700 *

Also Published As

Publication number Publication date
WO2006123156A2 (en) 2006-11-23
GB0510171D0 (en) 2005-06-22

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