WO2006121371A1 - Stimulation de tissus biologiques au moyen d'un traitement magneto-acoustique - Google Patents

Stimulation de tissus biologiques au moyen d'un traitement magneto-acoustique Download PDF

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Publication number
WO2006121371A1
WO2006121371A1 PCT/RU2006/000232 RU2006000232W WO2006121371A1 WO 2006121371 A1 WO2006121371 A1 WO 2006121371A1 RU 2006000232 W RU2006000232 W RU 2006000232W WO 2006121371 A1 WO2006121371 A1 WO 2006121371A1
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WO
WIPO (PCT)
Prior art keywords
magnetic field
frequency
tissue
acoustic waves
focusing
Prior art date
Application number
PCT/RU2006/000232
Other languages
English (en)
Russian (ru)
Inventor
Andrei Gervasievich Vasiliev
Vladimir Vasilievich Kopeikin
Original Assignee
Schekutiev, Georgy Alexandrovich
Margulis, Milya Arkadievich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schekutiev, Georgy Alexandrovich, Margulis, Milya Arkadievich filed Critical Schekutiev, Georgy Alexandrovich
Publication of WO2006121371A1 publication Critical patent/WO2006121371A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/002—Magnetotherapy in combination with another treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy

Definitions

  • the invention relates to a method for magnetoacoustic exposure to areas of biological tissues, for example, structures of the nervous system, or tissues of other organs of animals and humans, as well as a device that implements it, without using implantable electrodes. This allows for non-invasive effects.
  • Neurons and axons can be considered as biological conductors in which currents circulate in the form of nerve impulses that determine the nervous activity of the body.
  • an electrical contact of such a biological conductor with an electrode is carried out, when an external voltage is applied to it, a current from an external source begins to flow in the biological conductors.
  • This current has the desired effect of either stimulating or blocking the passage of nerve impulses.
  • the world's leading manufacturer of implantable stimulants is Medtropis (USA) (www.medtropys.com).
  • the main disadvantages of using the method of implantable stimulants are the following: - the need for surgical intervention, respectively, trauma, and as a consequence the risk of complications;
  • the main idea of the proposed method is that instead of connecting a biological conductor to an external current source through an implantable electrode, this current is generated directly in a selected area of the biological conductor (for example, in a neuron or axon).
  • EMF electromotive force
  • the essence of the proposed method is to place biological tissue (for example, brain tissue) in an external magnetic field and local excitation of the vibrational movement of the sections of the conductors
  • the advantages of this method of electrical stimulation are: non-invasiveness, the ability to focus the electric field and create a physiologically adequate current density in any required tissue volume of any location, ease of adjustment of stimulation parameters, painless stimulation procedure (in contrast to transcranial electrical stimulation, which is also extremely unfocused).
  • magnetoacoustic stimulation can be an effective tool in determining indications and places for implantation of electrodes in each individual case.
  • the proposed method can also stimulate spinal cord tissue and peripheral nerves.
  • the method can be applied to solve problems in the field of cardiology, which can also be solved by the proposed electrical stimulation.
  • Fig.l - is a structural diagram of the installation (top view).
  • Figure 2 - is a structural diagram of the installation (side view).
  • the invention is described below by the example of remote electrical stimulation of deep brain structures by the proposed method.
  • the nervous tissue of the brain instead of the nervous tissue of the brain, it is also possible to act on other tissues of the human or animal body.
  • E is the EMF induced in a conductor of length 1 moving at a speed V in a magnetic field of magnitude B.
  • the conductor is a neuron or axon.
  • Formula (1) can be used to describe the mechanism of the occurrence of electric current in a biological conductor.
  • the induction EMF induced in the conductor depends on the magnitude of the magnetic field and the mechanical speed of the conductor.
  • the induced EMF will also be a variable.
  • a sufficiently high frequency of ultrasound is necessary, since the “spot” of focusing depends on the length of the ultrasonic wave.
  • the magnitude of this spot is approximately equal to several wavelengths.
  • a short wavelength is needed, i.e. high frequency.
  • the frequency of the induced current will also be equal to 1 MHz.
  • a current of this frequency does not have an exciting electric effect on neurons and axons.
  • the magnetic field must change with a frequency f + F or f - F.
  • a low difference frequency F (the first term on the right-hand side of (2)) appears in the spectrum of the current induced in the biological conductor.
  • t is time.
  • V is the mechanical vibrational velocity biological conductor, which does not move with the ultrasonic wave, but remains in place, performing only oscillations.
  • the changing magnetic field of the indicated frequency also has an oscillatory (quasistatic) character.
  • FIGS. L and 2 The block diagram of the installation is illustrated in FIGS. L and 2.
  • the head of patient 1 is partially immersed in a container 5 filled with physiological saline, distilled water or gel, which has acoustic properties close to human tissues. Coordination of the acoustic properties of the solution and human tissues is necessary so that ultrasound from the solution can pass into these tissues without noticeable attenuation.
  • the solution contains a focusing ultrasound source 3 in the form of a concave piezoceramic plate. The concavity of the plate provides focusing.
  • Around the head are turns (one or more) of an electric wire, which is a winding of an electromagnet 4 for
  • the operating frequency range of ultrasound is from 0.3 to 5 MHz.
  • the formation of ultrasonic vibrations is possible in both pulsed and continuous modes.
  • FIXED SHEET (RULE 91 ISA / RU)
  • the ultrasonic wave can be focused in several ways:
  • Reflective mirrors 1.
  • a radiating plate having a concave geometry in this case, the momentum can be transmitted to the brain structures through an elastic pad, for example, in the form of a gel-filled pillow, which does not require placing the person’s head in a “container”.
  • a phase grating the emitters of which can be applied directly to the head, which is most optimal for focusing and research, but requires large expenses for calculations and manufacturing.
  • the synchronization of acoustic and magnetic waves can be carried out in one of the following ways.
  • the initial phases of the ultrasonic and magnetic pulses must coincide, for example, when the unit is switched on from one toggle switch or through a special pulse generator.
  • the frequency F is not equal to zero, synchronization is not required.
  • Installation works as follows. Selected area of the brain 2, which should be subjected to electrostimulating effects. The focus of the piezoceramic ultrasound source 3 is aimed at this area by moving the piezoacoustic system 3 inside the vessel 6.
  • the ultrasonic emitter 3 and the electromagnet 4 synchronized with it in frequency are turned on (synchronization provides the necessary frequency spacing between the acoustic and magnetic fields), which will lead to mechanical vibrations of neurons and their axons at the focal point under the influence of ultrasound and the appearance of electromagnetic induction in them in accordance with formula (1) i.e. stimulating impulse.
  • a stimulating impulse can be used to excite or inhibit (depending on the frequency of the impulses) in the corresponding structures - targets of the nervous system and, thereby, provide a therapeutic effect in a number of diseases.
  • Vasin H.Ya., Majorchik B.E., Safronov V.A The effects of electrical stimulation and destruction of the median center of the optic tubercle in patients with an akinetic-rigid form of parkinsonism. / Journal. neuropath, psychiatrist. 1979; 79 (9): 1341-1346.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Magnetic Treatment Devices (AREA)
  • Surgical Instruments (AREA)

Abstract

L'invention concerne un procédé de traitement stimulant des zones d'un tissu biologique (du cerveau ou d'autres organes de l'humain ou d'un animal) ainsi qu'un dispositif de sa mise en oeuvre, qui n'utilisent pas de conducteurs électriques (d'électrodes). Selon l'invention, on a créé un courant de stimulation directement dans le tissu biologique par la génération autour du tissu d'un champ magnétique externe et par l'excitation locale d'un mouvement ondulatoire mécanique de ce tissu au moyen d'ondes ultrasonores focalisées dans cette zone. Selon la loi d'induction électromagnétique dans la zone sélectionnée du tissu biologique, qui oscille mécaniquement dans le champ magnétique, un courant est créé, qui a un effet stimulant. Ce procédé a les avantages suivants: caractère non invasif, possibilité d'action focalisée et de création d'une densité de courant adéquate du point de vue physiologique dans n'importe quel volume nécessaire du tissu et avec n'importe quelle localisation, simplicité des réglages des paramètres de stimulation, et absence de douleur de la procédure de stimulation.
PCT/RU2006/000232 2005-05-12 2006-05-05 Stimulation de tissus biologiques au moyen d'un traitement magneto-acoustique WO2006121371A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2005114342/14A RU2316368C2 (ru) 2005-05-12 2005-05-12 Стимуляция биологических тканей с помощью магнитоакустического воздействия
RU2005114342 2005-05-12

Publications (1)

Publication Number Publication Date
WO2006121371A1 true WO2006121371A1 (fr) 2006-11-16

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2006/000232 WO2006121371A1 (fr) 2005-05-12 2006-05-05 Stimulation de tissus biologiques au moyen d'un traitement magneto-acoustique

Country Status (2)

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RU (1) RU2316368C2 (fr)
WO (1) WO2006121371A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108904974A (zh) * 2018-05-24 2018-11-30 中国医学科学院生物医学工程研究所 结合超声磁声的电刺激电流监测装置及监测方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013170111A1 (fr) * 2012-05-11 2013-11-14 Richard Bernstein Dispositif de stimulation de croissance d'os intra-buccal et de tissu mou
EA030491B1 (ru) * 2014-05-19 2018-08-31 Сергей Владимирович ПЛЕТНЕВ Способ подавления роста опухоли и система для осуществления способа
WO2017037519A1 (fr) * 2015-09-04 2017-03-09 Сергей Владимирович ПЛЕТНЕВ Méthodes d'action sur les tissus biologiques et système pour la mise en oeuvre de ces méthodes

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2091185C1 (ru) * 1995-07-20 1997-09-27 Институт микроэлектроники РАН Фокусирующий акустический преобразователь
US6585763B1 (en) * 1997-10-14 2003-07-01 Vascusense, Inc. Implantable therapeutic device and method
RU2209097C1 (ru) * 2002-06-25 2003-07-27 Муниципальное медицинское учреждение 1-я городская клиническая больница Комитет здравоохранения администрации города Саратова Устройство для электромагнитной терапии

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2091185C1 (ru) * 1995-07-20 1997-09-27 Институт микроэлектроники РАН Фокусирующий акустический преобразователь
US6585763B1 (en) * 1997-10-14 2003-07-01 Vascusense, Inc. Implantable therapeutic device and method
RU2209097C1 (ru) * 2002-06-25 2003-07-27 Муниципальное медицинское учреждение 1-я городская клиническая больница Комитет здравоохранения администрации города Саратова Устройство для электромагнитной терапии

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108904974A (zh) * 2018-05-24 2018-11-30 中国医学科学院生物医学工程研究所 结合超声磁声的电刺激电流监测装置及监测方法

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Publication number Publication date
RU2316368C2 (ru) 2008-02-10
RU2005114342A (ru) 2006-11-20

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