WO2006119914A3 - Verfahren und vorrichtung zur bestimmung der glucose-konzentration in gewebeflüssigkeit - Google Patents

Verfahren und vorrichtung zur bestimmung der glucose-konzentration in gewebeflüssigkeit Download PDF

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Publication number
WO2006119914A3
WO2006119914A3 PCT/EP2006/004179 EP2006004179W WO2006119914A3 WO 2006119914 A3 WO2006119914 A3 WO 2006119914A3 EP 2006004179 W EP2006004179 W EP 2006004179W WO 2006119914 A3 WO2006119914 A3 WO 2006119914A3
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WO
WIPO (PCT)
Prior art keywords
glucose
reference substance
determining
concentration
glucose concentration
Prior art date
Application number
PCT/EP2006/004179
Other languages
English (en)
French (fr)
Other versions
WO2006119914A2 (de
Inventor
Stefano Ferrari
Ortrud Quarder
Peter Stephan
Original Assignee
Hoffmann La Roche
Roche Diagnostics Gmbh
Stefano Ferrari
Ortrud Quarder
Peter Stephan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche, Roche Diagnostics Gmbh, Stefano Ferrari, Ortrud Quarder, Peter Stephan filed Critical Hoffmann La Roche
Priority to JP2008509379A priority Critical patent/JP2008541028A/ja
Priority to EP06742798A priority patent/EP1879494A2/de
Priority to CA002607396A priority patent/CA2607396A1/en
Publication of WO2006119914A2 publication Critical patent/WO2006119914A2/de
Publication of WO2006119914A3 publication Critical patent/WO2006119914A3/de
Priority to US11/936,569 priority patent/US8114623B2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14525—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using microdialysis
    • A61B5/14528—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using microdialysis invasively
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1473—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Optics & Photonics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Emergency Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • External Artificial Organs (AREA)

Abstract

Die Erfindung betrifft ein Verfahren und eine Vorrichtung zur Bestimmung der Glucose-Konzentration in Gewebeflüssigkeit (40), womit in einer durch Mikrodialyse, Mikroperfusion oder Ultrafiltration (Sonde 10) erhaltenen Probenflüssigkeit (42) Messwerte für Glucose und für eine endogene Referenzsubstanz erfasst werden (Sensor 12) und der Glucosewert nach Maßgabe des Messwerts für die Referenzsubstanz korrigiert wird. Hier wird vorgeschlagen, dass die Wiederfindungsrate für Glucose aus einer nichtlinearen Beziehung zu der Wiederfindungsrate für die ionische Referenzsubstanz bestimmt und der Glucose-Messwert damit korrigiert wird, und dass zudem die Konzentration von Lactat und/oder Pyruvat als weitere Referenzsubstanz in der Probenflüssigkeit zur weiteren Korrektur herangezogen wird.
PCT/EP2006/004179 2005-05-07 2006-05-04 Verfahren und vorrichtung zur bestimmung der glucose-konzentration in gewebeflüssigkeit WO2006119914A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2008509379A JP2008541028A (ja) 2005-05-07 2006-05-04 組織液中のグルコース濃度の決定のための方法および装置
EP06742798A EP1879494A2 (de) 2005-05-07 2006-05-04 Verfahren und vorrichtung zur bestimmung der glucose-konzentration in gewebeflüssigkeit
CA002607396A CA2607396A1 (en) 2005-05-07 2006-05-04 Method and device for determining the glucose concentration in tissue liquid
US11/936,569 US8114623B2 (en) 2005-05-07 2007-11-07 Method for determining glucose concentration in tissue fluid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05009986.0 2005-05-07
EP05009986A EP1719447A1 (de) 2005-05-07 2005-05-07 Verfahren und Vorrichtung zur Bestimmung der Glucose-Konzentration in Gewebflüssigkeit

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/936,569 Continuation US8114623B2 (en) 2005-05-07 2007-11-07 Method for determining glucose concentration in tissue fluid

Publications (2)

Publication Number Publication Date
WO2006119914A2 WO2006119914A2 (de) 2006-11-16
WO2006119914A3 true WO2006119914A3 (de) 2007-02-01

Family

ID=35455901

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/004179 WO2006119914A2 (de) 2005-05-07 2006-05-04 Verfahren und vorrichtung zur bestimmung der glucose-konzentration in gewebeflüssigkeit

Country Status (6)

Country Link
US (1) US8114623B2 (de)
EP (2) EP1719447A1 (de)
JP (1) JP2008541028A (de)
CN (1) CN101170942A (de)
CA (1) CA2607396A1 (de)
WO (1) WO2006119914A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8246541B2 (en) 2009-04-07 2012-08-21 Carnegie Mellon University Real-time microdialysis system
CA2785308C (en) * 2009-12-30 2017-06-27 Maquet Critical Care Ab System and method for continuous monitoring and presenting of body substances
JP5735773B2 (ja) * 2010-03-29 2015-06-17 シスメックス株式会社 生体成分分析方法及び生体成分分析装置
EP2436311A1 (de) * 2010-10-04 2012-04-04 PharmaSens AG Diagnostische Vorrichtung
JP5792517B2 (ja) * 2011-06-02 2015-10-14 国立大学法人長岡技術科学大学 ストレスの評価方法
DE102017110269A1 (de) * 2017-05-11 2018-11-15 B. Braun Avitum Ag Online Linearisierung eines optischen Sensors
US11766510B2 (en) * 2020-05-11 2023-09-26 Covidien Lp Wearable microdialysis device for early detection of anastomotic leaks

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0367752A1 (de) * 1988-10-31 1990-05-09 AVL Medical Instruments AG Vorrichtung zur Bestimmung der Konzentration von zumindest einer in organischem Gewebe vorliegenden Substanz
DE4123441A1 (de) * 1990-07-19 1992-01-23 Avl Medical Instr Ag Vorrichtung zur bestimmung der konzentration von zumindest einer in organischem gewebe vorliegenden substanz
US5118473A (en) * 1989-09-18 1992-06-02 Nova Biomedical Corporation Apparatus for determining the concentration of water soluble species in biological fluid
EP0534074A1 (de) * 1991-09-16 1993-03-31 Institut für Diabetestechnologie gemeinnützige Forschungs- und Entwicklungsgesellschaft mbH Verfahren und Anordnung zur Bestimmung der Konzentration von Inhaltsstoffen in Körperflüssigkeiten
EP0664989A1 (de) * 1994-01-19 1995-08-02 Ernst Prof. Dr. Pfeiffer Verfahren und Anordnung zur kontinuierlichen Überwachung der Konzentration eines Metaboliten
EP1072222A2 (de) * 1999-07-28 2001-01-31 Roche Diagnostics GmbH Verfahren und Anordnung zur Konzentrationsbestimmung von Glucose in einer Körperflüssigkeit
WO2003003911A2 (de) * 2001-07-06 2003-01-16 Lukas Schaupp Messung der konzentration von substanzen in lebenden organismen mittels mikrodialyse

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT391998B (de) 1987-02-02 1990-12-27 Falko Dr Skrabal Vorrichtung zur bestimmung der konzentration zumindest einer medizinischen substanz in lebenden organismen
ATE155689T1 (de) * 1991-01-10 1997-08-15 Amylin Pharmaceuticals Inc Aktivätsmessungen des amylin
US7383069B2 (en) * 1997-08-14 2008-06-03 Sensys Medical, Inc. Method of sample control and calibration adjustment for use with a noninvasive analyzer

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0367752A1 (de) * 1988-10-31 1990-05-09 AVL Medical Instruments AG Vorrichtung zur Bestimmung der Konzentration von zumindest einer in organischem Gewebe vorliegenden Substanz
US5118473A (en) * 1989-09-18 1992-06-02 Nova Biomedical Corporation Apparatus for determining the concentration of water soluble species in biological fluid
DE4123441A1 (de) * 1990-07-19 1992-01-23 Avl Medical Instr Ag Vorrichtung zur bestimmung der konzentration von zumindest einer in organischem gewebe vorliegenden substanz
EP0534074A1 (de) * 1991-09-16 1993-03-31 Institut für Diabetestechnologie gemeinnützige Forschungs- und Entwicklungsgesellschaft mbH Verfahren und Anordnung zur Bestimmung der Konzentration von Inhaltsstoffen in Körperflüssigkeiten
EP0664989A1 (de) * 1994-01-19 1995-08-02 Ernst Prof. Dr. Pfeiffer Verfahren und Anordnung zur kontinuierlichen Überwachung der Konzentration eines Metaboliten
EP1072222A2 (de) * 1999-07-28 2001-01-31 Roche Diagnostics GmbH Verfahren und Anordnung zur Konzentrationsbestimmung von Glucose in einer Körperflüssigkeit
WO2003003911A2 (de) * 2001-07-06 2003-01-16 Lukas Schaupp Messung der konzentration von substanzen in lebenden organismen mittels mikrodialyse

Also Published As

Publication number Publication date
CA2607396A1 (en) 2006-11-16
JP2008541028A (ja) 2008-11-20
CN101170942A (zh) 2008-04-30
US8114623B2 (en) 2012-02-14
WO2006119914A2 (de) 2006-11-16
EP1879494A2 (de) 2008-01-23
US20080153118A1 (en) 2008-06-26
EP1719447A1 (de) 2006-11-08

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