WO2006117763A3 - A process for the preparation of doripenem - Google Patents

A process for the preparation of doripenem Download PDF

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Publication number
WO2006117763A3
WO2006117763A3 PCT/IB2006/051398 IB2006051398W WO2006117763A3 WO 2006117763 A3 WO2006117763 A3 WO 2006117763A3 IB 2006051398 W IB2006051398 W IB 2006051398W WO 2006117763 A3 WO2006117763 A3 WO 2006117763A3
Authority
WO
WIPO (PCT)
Prior art keywords
doripenem
preparation
formula
present
amorphous form
Prior art date
Application number
PCT/IB2006/051398
Other languages
French (fr)
Other versions
WO2006117763A2 (en
Inventor
Neera Tewari
Hashim Nizar Poovanathi Meeran
Bishwa Prakash Rai
Vinod George
Original Assignee
Ranbaxy Lab Ltd
Neera Tewari
Hashim Nizar Poovanathi Meeran
Bishwa Prakash Rai
Vinod George
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd, Neera Tewari, Hashim Nizar Poovanathi Meeran, Bishwa Prakash Rai, Vinod George filed Critical Ranbaxy Lab Ltd
Publication of WO2006117763A2 publication Critical patent/WO2006117763A2/en
Publication of WO2006117763A3 publication Critical patent/WO2006117763A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D477/08—Modification of a carboxyl group directly attached in position 2, e.g. esterification

Abstract

The present invention provides processes for the preparation of doripenem of formula (I) and for the preparation of doripenem in amorphous form.
PCT/IB2006/051398 2005-05-03 2006-05-03 A process for the preparation of doripenem WO2006117763A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN1104DE2005 2005-05-03
IN1104/DEL/2005 2005-05-03
IN1699/DEL/2005 2005-06-30
IN1699DE2005 2005-06-30

Publications (2)

Publication Number Publication Date
WO2006117763A2 WO2006117763A2 (en) 2006-11-09
WO2006117763A3 true WO2006117763A3 (en) 2007-04-05

Family

ID=36814789

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/051398 WO2006117763A2 (en) 2005-05-03 2006-05-03 A process for the preparation of doripenem

Country Status (1)

Country Link
WO (1) WO2006117763A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7932381B2 (en) 2005-02-15 2011-04-26 Shionogi & Co., Ltd. Process for producing carbapenem derivative and intermediate crystal therefor
PL2276762T3 (en) 2008-03-24 2015-06-30 Ranbaxy Laboratories Ltd Process for the preparation of sterile doripenem
WO2010097686A1 (en) * 2009-02-26 2010-09-02 Orchid Chemicals & Pharmaceuticals Ltd An improved process for the preparation of carbapenem antibiotic
WO2012114280A1 (en) * 2011-02-23 2012-08-30 Orchid Chemicals And Pharmaceuticals Limited An improved process for the preparation of pyrrolidine thiol derivatives useful in the synthesis of carbapenem compounds
US20150291591A1 (en) 2011-11-08 2015-10-15 Ranbaxy Laboratories Limited Process for the preparation of polymorphs of doripenem
CN102372714B (en) * 2011-12-07 2014-04-16 凯莱英医药集团（天津）股份有限公司 Method for preparing doripenem
CN102372715A (en) * 2011-12-07 2012-03-14 凯莱英医药集团（天津）股份有限公司 Method for preparing meropenem
JP2016501259A (en) 2012-12-04 2016-01-18 デーウン ファーマシューティカル カンパニー リミテッド Crystalline doripenem monohydrate and process for producing the same
CN103626771A (en) * 2013-11-22 2014-03-12 安徽悦康凯悦制药有限公司 Process for preparing doripenem
JP6477728B2 (en) * 2014-04-28 2019-03-06 ジェイダブリュ ファーマセウティカル コーポレーション Novel crystals of doripenem and method for producing the same

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0528678A1 (en) * 1991-08-20 1993-02-24 SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. A pyrrolidylthiocarbapenem derivative

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0528678A1 (en) * 1991-08-20 1993-02-24 SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. A pyrrolidylthiocarbapenem derivative

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NISHINO ET AL.: "Practical Large-scale Synthesis of Doripenem: A Novel 1beta-Methylcrabapenem Antibiotic", ORGANIC PROCESS RESEARCH & DEVELOPMENT, vol. 7, 2003, pages 846 - 850, XP002396087 *
YASUYOSHI ISO ET AL.: "Synthesis and Modification of a Novel 1beta-Methyl Carbapenem Antibiotic, S-4661", THE JOURNAL OF ANTIBIOTICS, vol. 49, no. 5, 1996, pages 478 - 484, XP008068113 *

Also Published As

Publication number Publication date
WO2006117763A2 (en) 2006-11-09

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