WO2006117218A3 - Serotonin-transport-protein binding radiopharmaceutical for the production of a diagnostic medicament for the diagnosis of headache - Google Patents

Serotonin-transport-protein binding radiopharmaceutical for the production of a diagnostic medicament for the diagnosis of headache Download PDF

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Publication number
WO2006117218A3
WO2006117218A3 PCT/EP2006/004181 EP2006004181W WO2006117218A3 WO 2006117218 A3 WO2006117218 A3 WO 2006117218A3 EP 2006004181 W EP2006004181 W EP 2006004181W WO 2006117218 A3 WO2006117218 A3 WO 2006117218A3
Authority
WO
WIPO (PCT)
Prior art keywords
serotonin
headache
transport
diagnosis
production
Prior art date
Application number
PCT/EP2006/004181
Other languages
French (fr)
Other versions
WO2006117218A2 (en
Inventor
Sigrid Schuh-Hofer
Arnold Guy
Matthias Richter
Original Assignee
Charite Universitaetsmedizin
Sigrid Schuh-Hofer
Arnold Guy
Matthias Richter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP05009822A external-priority patent/EP1728520A1/en
Application filed by Charite Universitaetsmedizin, Sigrid Schuh-Hofer, Arnold Guy, Matthias Richter filed Critical Charite Universitaetsmedizin
Publication of WO2006117218A2 publication Critical patent/WO2006117218A2/en
Publication of WO2006117218A3 publication Critical patent/WO2006117218A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention relates to the use of radiopharmaceuticals which specifically bind the serotonin-transport-protein (SERT) for the production of a diagnostic drug for the diagnosis of headache. The radiopharmaceuticals are tracers, which have the capacity to specifically bind the Serotonin-Transport-Protein in the context of a Positron-Emission-Tomography (PET) or a Single Photon Emission Tomography (SPECT). The present invention further relates to a screening method for identifying substances, which selectively modify the binding of these radiopharmaceuticals to the serotonin transporter. These substances are, e.g. precursors of putative therapeutics for the treatment of headache.
PCT/EP2006/004181 2005-05-04 2006-05-04 Serotonin-transport-protein binding radiopharmaceutical for the production of a diagnostic medicament for the diagnosis of headache WO2006117218A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP05009822A EP1728520A1 (en) 2005-05-04 2005-05-04 Use of radiopharmaceutical compounds which are specific binders to serotonine transporters for the preparation of a diagnotic agent for the examination of headache related disorders
EP05009822.7 2005-05-04
US71513905P 2005-09-09 2005-09-09
US60/715,139 2005-09-09

Publications (2)

Publication Number Publication Date
WO2006117218A2 WO2006117218A2 (en) 2006-11-09
WO2006117218A3 true WO2006117218A3 (en) 2007-12-13

Family

ID=36646112

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/004181 WO2006117218A2 (en) 2005-05-04 2006-05-04 Serotonin-transport-protein binding radiopharmaceutical for the production of a diagnostic medicament for the diagnosis of headache

Country Status (1)

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WO (1) WO2006117218A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116990498B (en) * 2023-09-28 2024-08-09 山东大学齐鲁医院 Application of plasma tryptophan metabolite in diagnosis of migraine in children

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
US6165716A (en) * 1995-09-23 2000-12-26 Medical Research Council Screening for disorders of serotonergic dysfunction
US20010047028A1 (en) * 1999-01-28 2001-11-29 Dan Peters Novel azabicyclo derivatives and their use
US20030091505A1 (en) * 2001-10-18 2003-05-15 Jian-Min Fu Tetracyclicazaindoles and indolines having 5-HT activity
US20030149024A1 (en) * 2001-11-28 2003-08-07 Jian-Min Fu Therapeutic compounds
US20040014992A1 (en) * 2000-10-17 2004-01-22 Meltzer Peter C. Compounds with high monoamine transporter affinity

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6165716A (en) * 1995-09-23 2000-12-26 Medical Research Council Screening for disorders of serotonergic dysfunction
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
US20010047028A1 (en) * 1999-01-28 2001-11-29 Dan Peters Novel azabicyclo derivatives and their use
US20040014992A1 (en) * 2000-10-17 2004-01-22 Meltzer Peter C. Compounds with high monoamine transporter affinity
US20030091505A1 (en) * 2001-10-18 2003-05-15 Jian-Min Fu Tetracyclicazaindoles and indolines having 5-HT activity
US20030149024A1 (en) * 2001-11-28 2003-08-07 Jian-Min Fu Therapeutic compounds

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ACTON P D ET AL: "Quantification of serotonin transporters in nonhuman primates using 123IADAM and single photon emission tomography", JOURNAL OF NUCLEAR MEDICINE, vol. 42, no. 10, October 2001 (2001-10-01), & 48TH ANNUAL MEETING OF THE SOCIETY OF NUCLEAR MEDICINE; TORONTO, ONTARIO, CANADA; JUNE 23-27, 2001, pages 1556 - 1562, XP002369625, ISSN: 0161-5505 *
DUCROS A ET AL: "The Genetics of Migraine", LANCET NEUROLOGY, LANCET PUBLISHING GROUP, LONDON, GB, vol. 1, no. 5, September 2002 (2002-09-01), pages 285 - 293, XP004811296, ISSN: 1474-4422 *
HESSE S ET AL: "Advances in in vivo imaging of serotonergic neurons in neuropsychiatric disorders", NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, PERGAMON PRESS LTD, XX, vol. 28, no. 6, October 2004 (2004-10-01), pages 547 - 563, XP004621916, ISSN: 0149-7634 *
LIN KUN-JU ET AL: "Characterization of the binding sites for 123I-ADAM and the relationship to the serotonin transporter in rat and mouse brains using quantitative autoradiography.", JOURNAL OF NUCLEAR MEDICINE : OFFICIAL PUBLICATION, SOCIETY OF NUCLEAR MEDICINE. APR 2004, vol. 45, no. 4, April 2004 (2004-04-01), pages 673 - 681, XP002369624, ISSN: 0161-5505 *
UEBELHACK R ET AL: "P.1.094 Reduction of the brain <123>I-ADAM binding isrelated to the plasma drug level in amitriptyline treated subjects", EUROPEAN NEUROPSYCHOPHARMACOLOGY, ELSEVIER SCIENCE PUBLISHERS BV, AMSTERDAM, NL, vol. 14, October 2004 (2004-10-01), pages S214 - S215, XP004990010, ISSN: 0924-977X *

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Publication number Publication date
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