WO2006116681A3 - Tat-003 and methods of assessing and treating cancer - Google Patents
Tat-003 and methods of assessing and treating cancer Download PDFInfo
- Publication number
- WO2006116681A3 WO2006116681A3 PCT/US2006/016242 US2006016242W WO2006116681A3 WO 2006116681 A3 WO2006116681 A3 WO 2006116681A3 US 2006016242 W US2006016242 W US 2006016242W WO 2006116681 A3 WO2006116681 A3 WO 2006116681A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tat
- expression
- methods
- identification
- activity
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57419—Specifically defined cancers of colon
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Hospice & Palliative Care (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Surprisingly, the present inventors have discovered that expression of TAT-003 protein in human patients is associated with cancer, and that the over-expressed protein is present in plasma membrane fractions. Thus, the present inventors have discovered that TAT-003 is associated with abnormal development and growth, and may be useful as a target for the identification of anti-cancer compounds, including antibodies for use in immunotherapy. Accordingly, the present invention provides methods for the identification of compounds that inhibit TAT-003 expression or activity, comprising: contacting a candidate compound with a TAT-003 and detecting the presence or absence of binding between said compound and said TAT-003, or detecting a change in TAT-003 expression or activity. Methods are also included for the identification of compounds that modulate TAT-003 expression or activity, comprising: administering a compound to a cell or cell population, and detecting a change in TAT-003 expression or activity. The methods of the invention are useful for the identification of anti-cancer compounds.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67560305P | 2005-04-28 | 2005-04-28 | |
| US60/675,603 | 2005-04-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2006116681A2 WO2006116681A2 (en) | 2006-11-02 |
| WO2006116681A3 true WO2006116681A3 (en) | 2009-04-16 |
Family
ID=37215547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2006/016242 WO2006116681A2 (en) | 2005-04-28 | 2006-04-28 | Tat-003 and methods of assessing and treating cancer |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2006116681A2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA45491A (en) * | 2016-06-27 | 2019-05-01 | Juno Therapeutics Inc | CMH-E RESTRICTED EPITOPES, BINDING MOLECULES AND RELATED METHODS AND USES |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003076578A2 (en) * | 2002-03-06 | 2003-09-18 | Curagen Corporation | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
-
2006
- 2006-04-28 WO PCT/US2006/016242 patent/WO2006116681A2/en active Application Filing
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003076578A2 (en) * | 2002-03-06 | 2003-09-18 | Curagen Corporation | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006116681A2 (en) | 2006-11-02 |
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| Date | Code | Title | Description |
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| 121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
| NENP | Non-entry into the national phase |
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