WO2006116503A3 - Methods and compositions for modulating wnt signaling pathway - Google Patents

Methods and compositions for modulating wnt signaling pathway Download PDF

Info

Publication number
WO2006116503A3
WO2006116503A3 PCT/US2006/015821 US2006015821W WO2006116503A3 WO 2006116503 A3 WO2006116503 A3 WO 2006116503A3 US 2006015821 W US2006015821 W US 2006015821W WO 2006116503 A3 WO2006116503 A3 WO 2006116503A3
Authority
WO
WIPO (PCT)
Prior art keywords
wnt signaling
signaling pathway
methods
compositions
modulating
Prior art date
Application number
PCT/US2006/015821
Other languages
French (fr)
Other versions
WO2006116503A2 (en
Inventor
Qisheng Zhang
Sheng Ding
Peter G Schultz
Original Assignee
Irm Llc
Scripps Research Inst
Qisheng Zhang
Sheng Ding
Peter G Schultz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Irm Llc, Scripps Research Inst, Qisheng Zhang, Sheng Ding, Peter G Schultz filed Critical Irm Llc
Publication of WO2006116503A2 publication Critical patent/WO2006116503A2/en
Publication of WO2006116503A3 publication Critical patent/WO2006116503A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

This invention provides novel Wnt signaling pathway regulators. The invention also provides methods of using the Wnt signaling pathway regulators to screen for compounds that modulate Wnt signaling pathway. The methods comprise first screening test compounds for modulators of a Wnt signaling pathway regulator disclosed herein, and then further screening the identified modulating agents for ability to modulate Wnt signaling pathway. The invention further provides methods for modulating Wnt signaling pathway and pharmaceutical compositions for treating diseases and conditions (e.g., tumors) associated with abnormal Wnt signaling activities.
PCT/US2006/015821 2005-04-26 2006-04-26 Methods and compositions for modulating wnt signaling pathway WO2006116503A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67530105P 2005-04-26 2005-04-26
US60/675,301 2005-04-26

Publications (2)

Publication Number Publication Date
WO2006116503A2 WO2006116503A2 (en) 2006-11-02
WO2006116503A3 true WO2006116503A3 (en) 2007-07-05

Family

ID=37101642

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/015821 WO2006116503A2 (en) 2005-04-26 2006-04-26 Methods and compositions for modulating wnt signaling pathway

Country Status (1)

Country Link
WO (1) WO2006116503A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9173871B2 (en) 2008-01-28 2015-11-03 New York University Oxazole and thiazole compounds as beta-catenin modulators and uses thereof
WO2009097113A2 (en) * 2008-01-28 2009-08-06 New York University Oxazole and thiazole compounds as b-catenin modulators and uses thereof
EP2283160A4 (en) * 2008-05-07 2012-01-04 Wintherix Llc Methods for identifying compounds that modulate wnt signaling in cancer cells
UA103918C2 (en) 2009-03-02 2013-12-10 Айерем Элелси N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators
US11702672B2 (en) 2016-02-08 2023-07-18 University Of Iowa Research Foundation Methods to produce chimeric adeno-associated virus/bocavirus parvovirus
CA3016985C (en) 2016-03-07 2023-07-04 University Of Iowa Research Foundation Aav-mediated expression using a synthetic promoter and enhancer
WO2018132747A1 (en) 2017-01-13 2018-07-19 University Of Iowa Research Foundation Bocaparvovirus small noncoding rna and uses thereof
US20210255170A1 (en) * 2018-03-13 2021-08-19 University Of Iowa Research Foundation Inductive regeneration of the airway by transcriptional factor modulation of glandular myoepithelial stem cells

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020049177A1 (en) * 2000-02-29 2002-04-25 Clark Abbot F. Diagnostics and therapeutics for glaucoma
US20030165500A1 (en) * 2001-05-01 2003-09-04 Regents Of The University Of California Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas
WO2005031003A1 (en) * 2003-09-22 2005-04-07 The Regents Of The University Of California Mutations in wnt-frizzled signaling pathways associated with osteoarthritis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020049177A1 (en) * 2000-02-29 2002-04-25 Clark Abbot F. Diagnostics and therapeutics for glaucoma
US20030165500A1 (en) * 2001-05-01 2003-09-04 Regents Of The University Of California Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas
WO2005031003A1 (en) * 2003-09-22 2005-04-07 The Regents Of The University Of California Mutations in wnt-frizzled signaling pathways associated with osteoarthritis

Also Published As

Publication number Publication date
WO2006116503A2 (en) 2006-11-02

Similar Documents

Publication Publication Date Title
WO2006116503A3 (en) Methods and compositions for modulating wnt signaling pathway
MX2021013197A (en) Substituted cycloalkyls as modulators of the integrated stress pathway.
WO2009076454A3 (en) Compounds that modulate intracellular calcium
WO2009035818A8 (en) Compounds that modulate intracellular calcium
WO2019090085A8 (en) Modulators of the integrated stress pathway
MX2010006379A (en) Gamma secretase modulators.
CR20230182A (en) Prodrug modulators of the integrated stress pathway
WO2010027875A3 (en) Compounds that modulate intracellular calcium
WO2007143689A8 (en) Compositions and methods for modulating vascular development
WO2008033408A3 (en) Methods for identifying compounds that modulate cell signaling and methods employing such compounds
WO2007094755A3 (en) Compositions and methods for modulating cognitive function
MX2009008923A (en) Compounds and methods for modulating g protein-coupled receptors.
NO20075412L (en) Methods and preparations for modulating hyper-stabilized C-MET
MX2010005028A (en) Gamma secretase modulators.
WO2006096487A3 (en) Methods and compositions for modulating tweak and fn14 activity
MX2023004870A (en) Modulators of the integrated stress pathway.
TW200636242A (en) Methods of modulating the activities of α7 nicotinic acetylcholine receptor
WO2007008982A3 (en) Methods and composition for modulating foxo1 activity and insulin signaling
WO2011034962A3 (en) Compounds that modulate intracellular calcium
WO2007067737A3 (en) Methods and compositions for inhibiting hiv infection
MX2010005704A (en) Chromane derivatives as trpv3 modulators.
EP1940407A4 (en) N-(4-oxo-3,4-dihydroquinazolin-2-yl)butanamides as androgen receptor modulators
MX2009003943A (en) Compositions and methods for modulating tlr14 activity.
WO2008008472A3 (en) Methods and compositions for modulating synapse formation
WO2010147969A3 (en) Gamma secretase modulators

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

NENP Non-entry into the national phase

Ref country code: RU

122 Ep: pct application non-entry in european phase

Ref document number: 06758632

Country of ref document: EP

Kind code of ref document: A2