WO2006114014A3 - Electrochemical patterning and dissolution of polyelectrolyte multilayers - Google Patents

Electrochemical patterning and dissolution of polyelectrolyte multilayers Download PDF

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Publication number
WO2006114014A3
WO2006114014A3 PCT/CH2006/000238 CH2006000238W WO2006114014A3 WO 2006114014 A3 WO2006114014 A3 WO 2006114014A3 CH 2006000238 W CH2006000238 W CH 2006000238W WO 2006114014 A3 WO2006114014 A3 WO 2006114014A3
Authority
WO
WIPO (PCT)
Prior art keywords
monolayers
active ingredient
dissolution
delivery system
drug delivery
Prior art date
Application number
PCT/CH2006/000238
Other languages
French (fr)
Other versions
WO2006114014A2 (en
Inventor
Fouzia Boulmedais
Clarence Tang
Janos VÖRÖS
Beat Keller
Marcus Textor
Original Assignee
Eth Zurich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eth Zurich filed Critical Eth Zurich
Publication of WO2006114014A2 publication Critical patent/WO2006114014A2/en
Publication of WO2006114014A3 publication Critical patent/WO2006114014A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites

Abstract

Described is an electric potential driven drug delivery system, which drug delivery system is suitable for the time dependent dispensing of at least one active ingredient. Said drug delivery system comprises at least one active ingredient, a substrate with at least a semi-conductive part, wherein at least said semi-conductive part is covered by at least one bilayer of oppositely charged monolayers. Said at least one active ingredient may form one of said monolayers, or said at least one active may be incorporated within one of the monolayers, or said active ingredient may form a layer that is placed between said two oppositely charged monolayers. For use, said multilayers covered substrate is connected to a regulating means that is suitable to change the potential of said substrate such that one or more of said monolayers - and therewith the active ingredient therein - are released.
PCT/CH2006/000238 2005-04-28 2006-04-28 Electrochemical patterning and dissolution of polyelectrolyte multilayers WO2006114014A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05009306 2005-04-28
EP05009306.1 2005-04-28

Publications (2)

Publication Number Publication Date
WO2006114014A2 WO2006114014A2 (en) 2006-11-02
WO2006114014A3 true WO2006114014A3 (en) 2010-10-07

Family

ID=37215103

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CH2006/000238 WO2006114014A2 (en) 2005-04-28 2006-04-28 Electrochemical patterning and dissolution of polyelectrolyte multilayers

Country Status (1)

Country Link
WO (1) WO2006114014A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020151776A1 (en) * 2000-05-30 2002-10-17 Shawgo Rebecca S. Methods and devices for sealing microchip reservoir devices

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020151776A1 (en) * 2000-05-30 2002-10-17 Shawgo Rebecca S. Methods and devices for sealing microchip reservoir devices

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DAI ZHIFEI; HEILIG ANNE; ZASTROW HEIDI; DONATH EDWIN; MÖHWALD HELMUTH: "Novel formulations of vitamins and insulin by nanoengineering of polyelectrolyte multilayers around microcrystals", CHEMISTRY (WEINHEIM AN DER BERGSTRASSE, GERMANY) 3 DEC 2004 LNKD- PUBMED:15532049, vol. 10, no. 24, 3 December 2004 (2004-12-03), pages 6369 - 6374, XP002593457, ISSN: 0947-6539, DOI: 10.1002/chem.200400579 *
RUIZ-TAYLOR L A ET AL: "Monolayers of derivatized poly(L-lysine)-grafted poly(ethylene glycol) on metal oxides as a class of biomolecular interfaces", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES (PNAS), NATIONAL ACADEMY OF SCIENCE, US LNKD- DOI:10.1073/PNAS.98.3.852, vol. 98, no. 3, 30 January 2001 (2001-01-30), pages 852 - 857, XP002251629, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
WO2006114014A2 (en) 2006-11-02

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