WO2006113782A3 - Lawsonia protein useful as a component in subunit vaccine and methods of making and using thereof - Google Patents

Lawsonia protein useful as a component in subunit vaccine and methods of making and using thereof Download PDF

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Publication number
WO2006113782A3
WO2006113782A3 PCT/US2006/014705 US2006014705W WO2006113782A3 WO 2006113782 A3 WO2006113782 A3 WO 2006113782A3 US 2006014705 W US2006014705 W US 2006014705W WO 2006113782 A3 WO2006113782 A3 WO 2006113782A3
Authority
WO
WIPO (PCT)
Prior art keywords
acid sequences
making
methods
component
subunit vaccine
Prior art date
Application number
PCT/US2006/014705
Other languages
French (fr)
Other versions
WO2006113782A2 (en
Inventor
Merrill Schaeffer
Jeremy Kroll
Mike Roof
Original Assignee
Boehringer Ingelheim Vetmed
Merrill Schaeffer
Jeremy Kroll
Mike Roof
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Vetmed, Merrill Schaeffer, Jeremy Kroll, Mike Roof filed Critical Boehringer Ingelheim Vetmed
Priority to US11/911,942 priority Critical patent/US20090215698A1/en
Priority to EP06758408A priority patent/EP1874804A4/en
Priority to JP2008507830A priority patent/JP2008538502A/en
Priority to CA002605250A priority patent/CA2605250A1/en
Publication of WO2006113782A2 publication Critical patent/WO2006113782A2/en
Publication of WO2006113782A3 publication Critical patent/WO2006113782A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/105—Delta proteobacteriales, e.g. Lawsonia; Epsilon proteobacteriales, e.g. campylobacter, helicobacter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention provides nucleic acid and amino acid sequences useful as the immunogenic portion of vaccines or immunogenic compositions effective for lessening the severity of the clinical symptoms associated with Lawsonia intracellularis infection or conferring protective immunity to an animal susceptible to such infection. Preferred amino acid sequences include at least 9 contiguous amino acids from SEQ ID NOS I (IDFKAKGVWDFNNFE), 3 (IDFKAKGVWDFNNFEWQQSSFMKG), or 7 (MICLG YKIS AGF AIGMIMVVLM). Thus, the nucleic acid sequences encoding such proteins, or the proteins themselves are included in vaccine compositions, together with veterinary-acceptable carrier and administered to an animal in need thereof.
PCT/US2006/014705 2005-04-18 2006-04-18 Lawsonia protein useful as a component in subunit vaccine and methods of making and using thereof WO2006113782A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US11/911,942 US20090215698A1 (en) 2005-04-18 2006-04-18 Lawsonia protein useful as a component in subunit vaccine and methods of making and using thereof
EP06758408A EP1874804A4 (en) 2005-04-18 2006-04-18 Lawsonia protein useful as a component in subunit vaccine and methods of making and using thereof
JP2008507830A JP2008538502A (en) 2005-04-18 2006-04-18 Lawsonia protein useful as a component in subunit vaccine, and its production and use
CA002605250A CA2605250A1 (en) 2005-04-18 2006-04-18 Lawsonia protein useful as a component in subunit vaccine and methods of making and using thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67245505P 2005-04-18 2005-04-18
US60/672,455 2005-04-18

Publications (2)

Publication Number Publication Date
WO2006113782A2 WO2006113782A2 (en) 2006-10-26
WO2006113782A3 true WO2006113782A3 (en) 2008-08-28

Family

ID=37115897

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/014705 WO2006113782A2 (en) 2005-04-18 2006-04-18 Lawsonia protein useful as a component in subunit vaccine and methods of making and using thereof

Country Status (5)

Country Link
US (1) US20090215698A1 (en)
EP (1) EP1874804A4 (en)
JP (1) JP2008538502A (en)
CA (1) CA2605250A1 (en)
WO (1) WO2006113782A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8834891B2 (en) 2005-03-14 2014-09-16 Boehringer Ingelheim Vetmedica, Inc. Immunogenic compositions comprising Lawsonia intracellularis
US8398994B2 (en) 2005-07-15 2013-03-19 Boehringer Ingelheim Vetmedica, Inc. Lawsonia vaccine and methods of use thereof
US8470336B2 (en) 2006-05-25 2013-06-25 Boehringer Ingelheim Vetmedica, Inc. Vaccination of young animals against Lawsonia intracellularis infections
WO2008073464A2 (en) 2006-12-11 2008-06-19 Boehringer Ingelheim Vetmedica, Inc. Effective method of treatment of porcine circovirus and lawsonia intracellularis infections
WO2009037262A2 (en) * 2007-09-17 2009-03-26 Boehringer Ingelheim Vetmedica, Inc. Method of preventing early lawsonia intracellularis infections

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1219711A2 (en) * 2000-12-20 2002-07-03 Akzo Nobel N.V. Lawsonia intracellularis vaccine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004033631A2 (en) * 2002-10-04 2004-04-22 Regents Of The University Of Minnesota Nucleic acid and polypeptide sequences from lawsonia intracellularis and methods of using

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1219711A2 (en) * 2000-12-20 2002-07-03 Akzo Nobel N.V. Lawsonia intracellularis vaccine

Also Published As

Publication number Publication date
EP1874804A4 (en) 2009-05-20
US20090215698A1 (en) 2009-08-27
CA2605250A1 (en) 2006-10-26
WO2006113782A2 (en) 2006-10-26
JP2008538502A (en) 2008-10-30
EP1874804A2 (en) 2008-01-09

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