WO2006113599A3 - Methods of diagnosing inflammatory diseases of intestine - Google Patents

Methods of diagnosing inflammatory diseases of intestine Download PDF

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Publication number
WO2006113599A3
WO2006113599A3 PCT/US2006/014362 US2006014362W WO2006113599A3 WO 2006113599 A3 WO2006113599 A3 WO 2006113599A3 US 2006014362 W US2006014362 W US 2006014362W WO 2006113599 A3 WO2006113599 A3 WO 2006113599A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
intestine
subclasses
antigens
inflammatory diseases
Prior art date
Application number
PCT/US2006/014362
Other languages
French (fr)
Other versions
WO2006113599A2 (en
Inventor
Grant Yeaman
David Mcguinness
Edward Organ
Kevin Osteen
Original Assignee
Univ Vanderbilt
Grant Yeaman
David Mcguinness
Edward Organ
Kevin Osteen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Vanderbilt, Grant Yeaman, David Mcguinness, Edward Organ, Kevin Osteen filed Critical Univ Vanderbilt
Publication of WO2006113599A2 publication Critical patent/WO2006113599A2/en
Publication of WO2006113599A3 publication Critical patent/WO2006113599A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/06—Gastro-intestinal diseases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/06—Gastro-intestinal diseases
    • G01N2800/065—Bowel diseases, e.g. Crohn, ulcerative colitis, IBS

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention provides methods of diagnosing an inflammatory disease of the intestine (IDI) based on detecting altered levels of individual antibody classes and/or subclasses that are specific for Tf-like and/or Tn-like antigens. Additionally, the present invention provides diagnostic methods based on detecting altered levels of two or more antibody classes and/or subclasses that are specific for Tf-like and/or Tn-like antigens. A discriminant function analysis is provided, which reflects the alterations of the levels of two or more antibody classes and/or subclasses that are specific for Tf-like and/or Tn-like antigens. Methods of treating an IDI are also provided.
PCT/US2006/014362 2005-04-15 2006-04-14 Methods of diagnosing inflammatory diseases of intestine WO2006113599A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67174505P 2005-04-15 2005-04-15
US60/671,745 2005-04-15

Publications (2)

Publication Number Publication Date
WO2006113599A2 WO2006113599A2 (en) 2006-10-26
WO2006113599A3 true WO2006113599A3 (en) 2006-12-21

Family

ID=37054510

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/014362 WO2006113599A2 (en) 2005-04-15 2006-04-14 Methods of diagnosing inflammatory diseases of intestine

Country Status (1)

Country Link
WO (1) WO2006113599A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201218341D0 (en) * 2012-10-12 2012-11-28 Orign Sciences Ltd Diagnostic method

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010039019A1 (en) * 1998-12-18 2001-11-08 Antonio Picarelli Method for the in vitro diagnosis of coeliac disease by secondary antibodies
US20010046713A1 (en) * 2000-04-19 2001-11-29 Research Corporation Technologies, Inc. Diagnostic assay for endometriosis
WO2005054853A2 (en) * 2003-12-03 2005-06-16 Glycominds, Ltd Method for diagnosing diseases based on levels of anti-glycan antibodies

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010039019A1 (en) * 1998-12-18 2001-11-08 Antonio Picarelli Method for the in vitro diagnosis of coeliac disease by secondary antibodies
US20010046713A1 (en) * 2000-04-19 2001-11-29 Research Corporation Technologies, Inc. Diagnostic assay for endometriosis
WO2005054853A2 (en) * 2003-12-03 2005-06-16 Glycominds, Ltd Method for diagnosing diseases based on levels of anti-glycan antibodies

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CAMPBELL BARRY J ET AL: "Altered glycosylation in inflammatory bowel disease: A possible role in cancer development.", GLYCOCONJUGATE JOURNAL, vol. 18, no. 11-12, November 2001 (2001-11-01), pages 851 - 858, XP009073572, ISSN: 0282-0080 *

Also Published As

Publication number Publication date
WO2006113599A2 (en) 2006-10-26

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