WO2006110177A3 - Microfluidic pumps and mixers driven by induced-charge electro-osmosis - Google Patents

Microfluidic pumps and mixers driven by induced-charge electro-osmosis Download PDF

Info

Publication number
WO2006110177A3
WO2006110177A3 PCT/US2005/037387 US2005037387W WO2006110177A3 WO 2006110177 A3 WO2006110177 A3 WO 2006110177A3 US 2005037387 W US2005037387 W US 2005037387W WO 2006110177 A3 WO2006110177 A3 WO 2006110177A3
Authority
WO
Grant status
Application
Patent type
Prior art keywords
osmosis
induced
microfluidic pumps
devices
mixers driven
Prior art date
Application number
PCT/US2005/037387
Other languages
French (fr)
Other versions
WO2006110177A2 (en )
Inventor
Jeremy Levitan
Martin Z Bazant
Martin Schmidt
Todd Thorsen
Original Assignee
Massachusetts Inst Technology
Jeremy Levitan
Martin Z Bazant
Martin Schmidt
Todd Thorsen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
    • B01F13/00Other mixers; Mixing plant, including combinations of mixers, e.g. of dissimilar mixers
    • B01F13/0059Micromixers
    • B01F13/0074Micromixers using mixing means not otherwise provided for
    • B01F13/0076Micromixers using mixing means not otherwise provided for using electrohydrodynamic [EHD] or electrokinetic [EKI] phenomena to mix or move the fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
    • B01F5/00Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F5/06Mixers in which the components are pressed together through slits, orifices, or screens; Static mixers; Mixers of the fractal type
    • B01F5/0602Static mixers, i.e. mixers in which the mixing is effected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F5/0609Mixing tubes, e.g. the material being submitted to a substantially radial movement or to a movement partially in reverse direction
    • B01F5/061Straight mixing tubes, e.g. with smooth walls, having baffles or obstructions therein without substantial pressure drop; Baffles therefor
    • B01F5/0618Straight mixing tubes, e.g. with smooth walls, having baffles or obstructions therein without substantial pressure drop; Baffles therefor the baffles being flat pieces of material, e.g. intermeshing, fixed to the wall, fixed on a central rod
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00Nanotechnology for materials or surface science, e.g. nanocomposites
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04POSITIVE DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04BPOSITIVE DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B19/00Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
    • F04B19/006Micropumps
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
    • B01F5/00Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F5/06Mixers in which the components are pressed together through slits, orifices, or screens; Static mixers; Mixers of the fractal type
    • B01F5/0602Static mixers, i.e. mixers in which the mixing is effected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F5/0609Mixing tubes, e.g. the material being submitted to a substantially radial movement or to a movement partially in reverse direction
    • B01F5/061Straight mixing tubes, e.g. with smooth walls, having baffles or obstructions therein without substantial pressure drop; Baffles therefor
    • B01F2005/062Straight mixing tubes, e.g. with smooth walls, having baffles or obstructions therein without substantial pressure drop; Baffles therefor characterised by the configuration of the baffles or obstructions
    • B01F2005/0621Profiled elements, e.g. profiled blades, bars, pillars, columns or chevrons
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
    • B01F5/00Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F5/06Mixers in which the components are pressed together through slits, orifices, or screens; Static mixers; Mixers of the fractal type
    • B01F5/0602Static mixers, i.e. mixers in which the mixing is effected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F5/0609Mixing tubes, e.g. the material being submitted to a substantially radial movement or to a movement partially in reverse direction
    • B01F5/061Straight mixing tubes, e.g. with smooth walls, having baffles or obstructions therein without substantial pressure drop; Baffles therefor
    • B01F2005/0635Straight mixing tubes, e.g. with smooth walls, having baffles or obstructions therein without substantial pressure drop; Baffles therefor characterised by the mounting of the baffles or obstructions
    • B01F2005/0636Mounted on the wall
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867Multiple inlets and one sample wells, e.g. mixing, dilution
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0418Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electro-osmotic flow [EOF]
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/08Regulating or influencing the flow resistance
    • B01L2400/084Passive control of flow resistance
    • B01L2400/086Passive control of flow resistance using baffles or other fixed flow obstructions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components

Abstract

This invention provides devices and apparatuses comprising the same, for the mixing and pumping of relatively small volumes of fluid. Such devices utilize nonlinear electrokinetics as a primary mechanism for driving fluid flow. Methods of cellular analysis and high-throughput, multi-step product formation using devices of this invention are described.
PCT/US2005/037387 2004-10-19 2005-10-19 Microfluidic pumps and mixers driven by induced-charge electro-osmosis WO2006110177A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US62000004 true 2004-10-19 2004-10-19
US60/620,000 2004-10-19

Publications (2)

Publication Number Publication Date
WO2006110177A2 true WO2006110177A2 (en) 2006-10-19
WO2006110177A3 true true WO2006110177A3 (en) 2007-04-19

Family

ID=37087463

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/037387 WO2006110177A3 (en) 2004-10-19 2005-10-19 Microfluidic pumps and mixers driven by induced-charge electro-osmosis

Country Status (1)

Country Link
WO (1) WO2006110177A3 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9034277B2 (en) * 2008-10-24 2015-05-19 Honeywell International Inc. Surface preparation for a microfluidic channel

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4908112A (en) * 1988-06-16 1990-03-13 E. I. Du Pont De Nemours & Co. Silicon semiconductor wafer for analyzing micronic biological samples
US5593565A (en) * 1993-09-23 1997-01-14 Ajdari; Armand Devices for separating particles contained in a fluid
US6086243A (en) * 1998-10-01 2000-07-11 Sandia Corporation Electrokinetic micro-fluid mixer
US6132580A (en) * 1995-09-28 2000-10-17 The Regents Of The University Of California Miniature reaction chamber and devices incorporating same
US6264825B1 (en) * 1998-06-23 2001-07-24 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
US6685809B1 (en) * 1999-02-04 2004-02-03 Ut-Battelle, Llc Methods for forming small-volume electrical contacts and material manipulations with fluidic microchannels
US6805783B2 (en) * 2000-12-13 2004-10-19 Toyo Technologies, Inc. Method for manipulating a solution using a ferroelectric electro-osmotic pump

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4908112A (en) * 1988-06-16 1990-03-13 E. I. Du Pont De Nemours & Co. Silicon semiconductor wafer for analyzing micronic biological samples
US5593565A (en) * 1993-09-23 1997-01-14 Ajdari; Armand Devices for separating particles contained in a fluid
US6132580A (en) * 1995-09-28 2000-10-17 The Regents Of The University Of California Miniature reaction chamber and devices incorporating same
US6264825B1 (en) * 1998-06-23 2001-07-24 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
US6086243A (en) * 1998-10-01 2000-07-11 Sandia Corporation Electrokinetic micro-fluid mixer
US6685809B1 (en) * 1999-02-04 2004-02-03 Ut-Battelle, Llc Methods for forming small-volume electrical contacts and material manipulations with fluidic microchannels
US6805783B2 (en) * 2000-12-13 2004-10-19 Toyo Technologies, Inc. Method for manipulating a solution using a ferroelectric electro-osmotic pump

Also Published As

Publication number Publication date Type
WO2006110177A2 (en) 2006-10-19 application

Similar Documents

Publication Publication Date Title
US20050037471A1 (en) Microfluidic rotary flow reactor matrix
Churski et al. High-throughput automated droplet microfluidic system for screening of reaction conditions
WO2006027757A3 (en) Microfluidic device using a collinear electric field
Tovar et al. Lateral cavity acoustic transducer
WO2005118857A3 (en) Methods and agents for screening for compounds capable of modulating vegf expression
WO2007133710A3 (en) Microfluidic devices and methods of use thereof
WO2010130762A3 (en) Apparatus for and method of automated processing of biological samples
CA2433145A1 (en) Microfluidic devices and methods for chemical assays
WO2004098757A3 (en) Microfluidic mixing using flow pulsing
WO2008115626A3 (en) Microfluidic and nanofluidic devices, systems, and applications
WO2006085948A2 (en) Real-time pcr detection of microorganisms using an integrated microfluidics platform
WO2004041061A8 (en) Substrates, devices, and methods for cellular assays
Han et al. An automated micro-solid phase extraction device involving integrated\high-pressure microvalves for genetic sample preparation
JP2009025301A (en) Micro chamber
WO2005003169A3 (en) Modified antibody fab fragments
Yoon et al. Active microdroplet merging by hydrodynamic flow control using a pneumatic actuator-assisted pillar structure
WO2007008276A3 (en) Turnover probes and use thereof for nucleic acid detection
WO2008073436A3 (en) Pumping system with two way communication
WO2005014650A3 (en) Antibodies specific for sclerostin and methods for increasing bone mineralization
WO2006074351A3 (en) Reversible nucleotide terminators and uses thereof
Takashima et al. Autonomous microfluidic control by chemically actuated micropumps and its application to chemical analyses
Ezkerra et al. SU8 diaphragm micropump with monolithically integrated cantilever check valves
WO2009008184A1 (en) Fluid mixing flow channel structure and method of fluid mixing
Niu et al. Microfluidic manipulation in lab-chips using electrorheological fluid
JP5440820B2 (en) The fluid control mechanism and a fluid control method of the microchip

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase in:

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 05857822

Country of ref document: EP

Kind code of ref document: A2